Determination of diagnostic value of harbor sample and detection of early IGG in development of haemorrhagic dengue fever syndrome
Abstract
106 blood sera from 101 patients with dengue fever were examined by ELISA-IgG-dengue kits. Among these patients, 16 patients were diagnosed with hemorrhagic dengue fever (DHF) on the basis of a positive tourniquet test. Thrombocytopenia was observed in 30 (35.3 %) patients with DF and 9 (56.3 %) patients with DHF. However, there were no differences between platelet levels in the sera of patients with DF and DHF. Detection of IgG antibodies at the early stage of the disease in the sera of both DHF patients and DF does not support the hypothesis of a connection between the development of hemorrhagic syndrome and the previously transferred flavivirus infection. We have no found a link between the presence of thrombocytopenia in patients with dengue fever, early anti-dengue IgG and a positive tourniquet test.
About the Authors
Yu. A. Akinshina
ECOlab Co
Russian Federation
Russian Federation
V. F. Larichev
Federal Research Centre for Epidemiology and Microbiology n.a. honorary academician N. F. Gamalei
Russian Federation
Russian Federation
M. A. Saifullin
Infectious Diseases Clinical Hospital № 1
Russian Federation
Russian Federation
S. G. Mardanly
State University of Humanities and Technology; ECOlab Co
Russian Federation
Russian Federation
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Review
For citations:
Akinshina Yu.A., Larichev V.F., Saifullin M.A., Mardanly S.G. Determination of diagnostic value of harbor sample and detection of early IGG in development of haemorrhagic dengue fever syndrome. Medical alphabet. 2018;1(5):60-62. (In Russ.)
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