Native type II collagen in musculoskeletal disorders: current practice and future directions
https://doi.org/10.33667/20785631202517913
Abstract
Collagen is a primary structural protein of connective tissue, accounting for over a quarter of all body proteins. Among 29 known collagen types, type II collagen is particularly significant as it forms the foundation of articular cartilage. Unlike hydrolyzed forms, native type II collagen (UC–II) maintains its original chemical structure, enabling it to function as an oral tolerance inducer. Clinical studies demonstrate effectiveness of UC–II in reducing inflammation, alleviating pain, and improving joint function in osteoarthritis and rheumatoid arthritis. A promising development direction involves marinederived collagen preparations with enhanced safety profiles. Large-scale studies are needed to optimize dosage regimens and administration methods.
Keywords
collagen,
native type II collagen,
collagen hydrolysates,
oral tolerance,
osteoarthritis,
rheumatoid arthritis
Supporting agencies: The publication was supported by the RUDN Strategic Academic Leadership Program.
About the Authors
E. A. Nikitina
Peoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Health; National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Nikitina Elena A., PhD Med, associate professor at Dept of Dietetics and Clinical Nutrition; research fellow; Expert of the Methodological Accreditation and Simulation Center
Moscow
S. V. Orlova
Peoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Health
Russian Federation
Russian Federation
Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology; chief researcher
Moscow
T. T. Batysheva
Peoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Health
Russian Federation
Russian Federation
Batysheva Tatyana T., DM Sci (habil.), professor, director; head. freelance pediatric specialist neurologist of the Dept of Healthcare, chief freelance children’s specialist in medical rehabilitation of the Russian Ministry of Health, head of Dept of Neurology, Physical, Rehabilitation Medicine and Childhood Psychology; Honored Doctor of the Russian Federation
Moscow
N. V. Balashova
Peoples’ Friendship University of Russia named after Patrice Lumumba; M. F. Vladimirskii Moscow Regional Scientific Research Institute (MONIKI)
Russian Federation
Russian Federation
Balashova Natalya V., PhD Bio, assistant professor at Dept of Clinical Laboratory Diagnostics of the Faculty of Advanced Training of Doctors; assistant professor at Dept of Dietetics and Clinical Nutritiology
Moscow
Author ID: 832745
M. V. Alekseeva
Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Health
Russian Federation
Russian Federation
Alekseeva Marina.V., PhD Med, deputy director for Organizational and Methodological Work
Moscow
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Review
For citations:
Nikitina E.A., Orlova S.V., Batysheva T.T., Balashova N.V., Alekseeva M.V. Native type II collagen in musculoskeletal disorders: current practice and future directions. Medical alphabet. 2025;(17):9-13. (In Russ.) https://doi.org/10.33667/20785631202517913
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