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Особенности микробиоты кишечника при заболеваниях желчевыводящих путей
https://doi.org/10.33667/2078-5631-2025-6-13-20
Аннотация
Цель исследования. Состав, метаболическая и иммунная активность микробиоты кишечника важны для нормального функционирования не только кишечника, но и других органов и систем.
Материалы и методы. В настоящем обзоре проанализированы литературные данные о взаимосвязи микробиоты кишечника при заболеваниях желчевыводящих путей.
Результаты и заключение. Изменения микробиоты кишечника могут вызывать не только изменения в системе органов пищеварения, но и влиять на состояние организма в целом.
Об авторах
С. Н. Котляров
ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И. П. Павлова» Минздрава России
Россия
Россия
Котляров Станислав Николаевич, д. м. н., доцент, заведующий кафедрой сестринского дела,
г. Рязань.
С. В. Шелухина
ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И. П. Павлова» Минздрава России
Россия
Россия
Шелухина Светлана Витальевна, к. м. н., ассистент кафедры сестринского дела,
г. Рязань.
Е. В. Маркова
ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И. П. Павлова» Минздрава России
Россия
Россия
Маркова Елена Владимировна, к. м. н., ассистент кафедры сестринского дела,
г. Рязань.
М. А. Бутов
ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И. П. Павлова» Минздрава России
Россия
Россия
Бутов Михаил Александрович, д. м. н., профессор, профессор кафедры сестринского дела, заслуженный врач Российской Федерации,
г. Рязань.
А. С. Василевская
ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И. П. Павлова» Минздрава России
Россия
Россия
Василевская Анна Станиславовна, к. м. н., доцент кафедры сестринского дела,
г. Рязань.
Список литературы
1. Zhou B, Yuan Y, Zhang S, Guo C, Li X, Li G, et al. Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract. Front Immunol. 2020; 11: 575.
2. Ivashkin VT, Fomin VV, Tkacheva ON, Medvedev OS, Poluektova EA, Abdulganieva DI, et al. Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution). Russ J Gastroenterol Hepatol Coloproctology. 2024 Feb 18; 34 (2): 14–34.
3. Zielińska M, Pawłowska A, Orzeł A, Sulej L, Muzyka-Placzyńska K, Baran A, et al. Wound Microbiota and Its Impact on Wound Healing. Int J Mol Sci. 2023 Dec 10; 24 (24): 17318.
4. Dempsey E, Corr SC. Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives. Front Immunol. 2022 Apr 6; 13: 840245.
5. Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI. Gut Microbiota and Immune System Interactions. Microorganisms. 2020 Oct 15; 8 (10): 1587.
6. Elgamal Z, Singh P, Geraghty P. The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease. Med Kaunas Lith. 2021 Aug 14; 57 (8): 823.
7. Kennedy MS, Chang EB. The microbiome: composition and locations. Prog Mol Biol Transl Sci. 2020; 176: 1–42.
8. Hou K, Wu ZX, Chen XY, Wang JQ, Zhang D, Xiao C, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 2022 Apr 23; 7 (1): 135.
9. Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol. 2016 Aug 19; 14 (8): e1002533.
10. Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol. 2021 Jul 7; 27 (25): 3837–50.
11. Rajilić-Stojanović M, de Vos WM. The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiol Rev. 2014 Sep; 38 (5): 996–1047.
12. Jiao N, Ke X, Zhu L, Zhu R. Evidence challenging the causal role of gut microbiota in inflammatory bowel diseases. Gastroenterol Rep. 2023 Oct 11; 11: goad064.
13. Wang R, Tang R, Li B, Ma X, Schnabl B, Tilg H. Gut microbiome, liver immunology, and liver diseases. Cell Mol Immunol. 2021 Jan; 18 (1): 4–17.
14. Athanasopoulou K, Adamopoulos PG, Scorilas A. Unveiling the Human Gastrointestinal Tract Microbiome: The Past, Present, and Future of Metagenomics. Biomedicines. 2023 Mar 9; 11 (3): 827.
15. Wang Q, Hao C, Yao W, Zhu D, Lu H, Li L, et al. Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation. BMC Gastroenterol. 2020 Mar 6; 20 (1): 59.
16. Lung microbiome: new insights into the pathogenesis of respiratory diseases | Signal Transduction and Targeted Therapy [Internet]. [cited 2025 Feb 6]. Available from: https://www.nature.com/articles/s41392-023-01722-y
17. de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022 May; 71 (5): 1020–32.
18. Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019 Jan 10; 7 (1): 14.
19. Li Z, Xiong W, Liang Z, Wang J, Zeng Z, Kołat D, et al. Critical role of the gut microbiota in immune responses and cancer immunotherapy. J Hematol OncolJ Hematol Oncol. 2024 May 14; 17 (1): 33.
20. Vaga S, Lee S, Ji B, Andreasson A, Talley NJ, Agréus L, et al. Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals. Sci Rep. 2020 Sep 11; 10 (1): 14977.
21. Juge N. Relationship between mucosa-associated gut microbiota and human diseases. Biochem Soc Trans. 2022 Oct 31; 50 (5): 1225–36.
22. Wang J, Feng J, Zhu Y, Li D, Wang J, Chi W. Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project. Front Microbiol. 2022 Jun 13; 13: 931065.
23. Baty JJ, Stoner SN, Scoffield JA. Oral Commensal Streptococci: Gatekeepers of the Oral Cavity. J Bacteriol. 204 (11): e00257-22.
24. Wen J, Lau HCH, Peppelenbosch M, Yu J. Gastric Microbiota beyond H. pylori: An Emerging Critical Character in Gastric Carcinogenesis. Biomedicines. 2021 Nov 12; 9 (11): 1680.
25. Rajilic-Stojanovic M, Figueiredo C, Smet A, Hansen R, Kupcinskas J, Rokkas T, et al. Systematic review: gastric microbiota in health and disease. Aliment Pharmacol Ther. 2020 Mar; 51 (6): 582–602.
26. Ohno H, Satoh-Takayama N. Stomach microbiota, Helicobacter pylori, and group 2 innate lymphoid cells. Exp Mol Med. 2020 Sep; 52 (9): 1377–82.
27. Kastl AJ, Terry NA, Wu GD, Albenberg LG. The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. Cell Mol Gastroenterol Hepatol. 2019 Jul 22; 9 (1): 33–45.
28. Jensen BAH, Heyndrickx M, Jonkers D, Mackie A, Millet S, Naghibi M, et al. Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration. Cell Rep Med. 2023 Sep 7; 4 (9): 101190.
29. Michaudel C, Sokol H. The Gut Microbiota at the Service of Immunometabolism. Cell Metab. 2020 Oct 6; 32 (4): 514–23.
30. Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek. 2020 Dec; 113 (12): 2019–40.
31. Bozomitu L, Miron I, Adam Raileanu A, Lupu A, Paduraru G, Marcu FM, et al. The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders. Biomedicines. 2022 Dec 2; 10 (12): 3117.
32. Pracht K, Wittner J, Kagerer F, Jäck HM, Schuh W. The intestine: A highly dynamic microenvironment for IgA plasma cells. Front Immunol. 2023 Feb 16; 14: 1114348.
33. Sasso JM, Ammar RM, Tenchov R, Lemmel S, Kelber O, Grieswelle M, et al. Gut Microbiome– Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders. ACS Chem Neurosci. 2023 May 8; 14 (10): 1717–63.
34. Ge Y, Wang X, Guo Y, Yan J, Abuduwaili A, Aximujiang K, et al. Gut microbiota influence tumor development and Alter interactions with the human immune system. J Exp Clin Cancer Res CR. 2021 Jan 25; 40 (1): 42.
35. Caballero-Flores G, Pickard JM, Núñez G. Microbiota-mediated colonization resistance: mechanisms and regulation. Nat Rev Microbiol. 2023 Jun; 21 (6): 347–60.
36. Nawaz N, Wen S, Wang F, Nawaz S, Raza J, Iftikhar M, et al. Lysozyme and Its Application as Antibacterial Agent in Food Industry. Molecules. 2022 Sep 24; 27 (19): 6305.
37. Larabi AB, Masson HLP, Bäumler AJ. Bile acids as modulators of gut microbiota composition and function. Gut Microbes. 2023; 15 (1): 2172671.
38. Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, et al. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol. 2003 May; 284 (5): R 1269–1276.
39. Drizaj E, Traini C, Vannucchi MG, Baccari MC. Nitric Oxide: From Gastric Motility to Gastric Dysmotility. Int J Mol Sci. 2021 Sep 16; 22 (18): 9990.
40. Nikolovska K, Seidler UE, Stock C. The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity. Front Physiol. 2022 May 18; 13: 899286.
41. Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22 (2): 292–8.
42. Salvi PS, Cowles RA. Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease. Cells. 2021 Jul 14; 10 (7): 1775.
43. Uebanso T, Shimohata T, Mawatari K, Takahashi A. Functional Roles of B-Vitamins in the Gut and Gut Microbiome. Mol Nutr Food Res. 2020 Sep; 64 (18): e2000426.
44. Tarracchini C, Lugli GA, Mancabelli L, van Sinderen D, Turroni F, Ventura M, et al. Exploring the vitamin biosynthesis landscape of the human gut microbiota. mSystems. 2024 Oct 22; 9 (10): e0092924.
45. Marasco G, Cremon C, Barbaro MR, Falangone F, Montanari D, Capuani F, et al. Pathophysiology and Clinical Management of Bile Acid Diarrhea. J Clin Med. 2022 May 30; 11 (11): 3102.
46. Markowiak-Kopeć P, Śliżewska K. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. 2020 Apr 16; 12 (4): 1107.
47. Liu J, Tan Y, Cheng H, Zhang D, Feng W, Peng C. Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives. Aging Dis. 2022 Jul 11; 13 (4): 1106–26.
48. Di Vincenzo F, Del Gaudio A, Petito V, Lopetuso LR, Scaldaferri F. Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern Emerg Med. 2024; 19 (2): 275–93.
49. Notarbartolo V, Carta M, Accomando S, Giuffrè M. The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children. Nutrients. 2023 Sep 16; 15 (18): 4014.
50. Nishida A, Nishino K, Ohno M, Sakai K, Owaki Y, Noda Y, et al. Update on gut microbiota in gastrointestinal diseases. World J Clin Cases. 2022 Aug 6; 10 (22): 7653–64.
51. Villavicencio Kim J, Wu GY. Update on Sphincter of Oddi Dysfunction: A Review. J Clin Transl Hepatol. 2022 Jun 28; 10 (3): 515–21.
52. Corazziari E, Shaffer EA, Hogan WJ, Sherman S, Toouli J. Functional disorders of the biliary tract and pancreas. Gut. 1999 Sep; 45 (Suppl 2): II48–54.
53. Simon DA, Friesen CA, Schurman JV, Colombo JM. Biliary Dyskinesia in Children and Adolescents: A Mini Review. Front Pediatr. 2020 Mar 24; 8: 122.
54. Kegnæs M, Novovic S, Shabanzadeh DM. Dysfunction of Biliary Sphincter of Oddi – Clinical, Diagnostic and Treatment Challenges. J Clin Med. 2023 Jul 20; 12 (14): 4802.
55. Georgescu D, Ionita I, Lascu A, Hut EF, Dragan S, Ancusa OE, et al. Gallstone Disease and Bacterial Metabolic Performance of Gut Microbiota in Middle-Aged and Older Patients. Int J Gen Med. 2022; 15: 5513–31.
56. Kazi FN, Ghosh S, Sharma JVP, Saravanan S, Patil S. Trends in Gallbladder Disease in Young Adults: A Growing Concern. Cureus. 14 (8): e28555.
57. Porges SW, Furman SA. The Early Development of the Autonomic Nervous System Provides a Neural Platform for Social Behavior: A Polyvagal Perspective. Infant Child Dev. 2011 Feb; 20 (1): 106–18.
58. Goldberger JJ, Arora R, Buckley U, Shivkumar K. Autonomic Nervous System Dysfunction. J Am Coll Cardiol. 2019 Mar 19; 73 (10): 1189–206.
59. Futagami S, Yamawaki H, Agawa S, Higuchi K, Ikeda G, Noda H, et al. New classification Rome IV functional dyspepsia and subtypes. Transl Gastroenterol Hepatol. 2018 Sep 19; 3: 70.
60. Behar J, Corazziari E, Guelrud M, Hogan W, Sherman S, Toouli J. Functional gallbladder and sphincter of oddi disorders. Gastroenterology. 2006 Apr; 130 (5): 1498–509.
61. Dan WY, Yang YS, Peng LH, Sun G, Wang ZK. Gastrointestinal microbiome and cholelithiasis: Current status and perspectives. World J Gastroenterol. 2023 Mar 14; 29 (10): 1589–601.
62. Grigor’eva I, Romanova T, Naumova N, Alikina T, Kuznetsov A, Kabilov M. Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients. J Pers Med. 2021 Apr 12; 11 (4): 294.
63. Liu L, Zhao Z, Hou X, Wu J. Effect of sphincter of Oddi dysfunction on the abundance of biliary microbiota (biliary microecology) in patients with common bile duct stones. Front Cell Infect Microbiol. 2022; 12: 1001441.
64. Menon S, Holt A, Farmer AD. Intra-sphincteric botulinum toxin in the management of functional biliary pain. Endosc Int Open. 2022 Apr; 10 (4): E 521–7.
65. Ticho AL, Malhotra P, Dudeja PK, Gill RK, Alrefai WA. Bile Acid Receptors and Gastrointestinal Functions. Liver Res. 2019 Mar; 3 (1): 31–9.
66. Fan Y, Xu C, Xie L, Wang Y, Zhu S, An J, et al. Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation. Front Cell Infect Microbiol. 2022; 12: 956528.
67. Guo X, Okpara ES, Hu W, Yan C, Wang Y, Liang Q, et al. Interactive Relationships between Intestinal Flora and Bile Acids. Int J Mol Sci. 2022 Jul 28; 23 (15): 8343.
68. Li J, Zhang R, Ma J, Tang S, Li Y, Li Y, et al. Mucosa-Associated Microbial Profile Is Altered in Small Intestinal Bacterial Overgrowth. Front Microbiol. 2021; 12: 710940.
69. Takakura W, Pimentel M. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update. Front Psychiatry. 2020; 11: 664.
70. Leite G, Morales W, Weitsman S, Celly S, Parodi G, Mathur R, et al. The duodenal microbiome is altered in small intestinal bacterial overgrowth. PLoS ONE. 2020 Jul 9; 15 (7): e0234906.
71. Sachdev AH, Pimentel M. Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance. Ther Adv Chronic Dis. 2013 Sep; 4 (5): 223–31.
72. Efremova I, Maslennikov R, Poluektova E, Vasilieva E, Zharikov Y, Suslov A, et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023 Jun 14; 29 (22): 3400–21.
73. Funch-Jensen P, Drewes AM, Madácsy L. Evaluation of the biliary tract in patients with functional biliary symptoms. World J Gastroenterol WJG. 2006 May 14; 12 (18): 2839–45.
74. Ghosh G, Jesudian AB. Small Intestinal Bacterial Overgrowth in Patients With Cirrhosis. J Clin Exp Hepatol. 2019; 9 (2): 257–67.
75. Shi X, Chen Z, Yang Y, Yan S. Bile Reflux Gastritis: Insights into Pathogenesis, Relevant Factors, Carcinomatous Risk, Diagnosis, and Management. Gastroenterol Res Pract. 2022 Sep 12; 2022: 2642551.
76. Taşcı EK, Karakoyun M, Sezak M, Doğanavsargil B, Çetin F, Aydoğdu S. Does bile reflux reduce Helicobacter pylori gastritis? Turk J Pediatr. 2022; 64 (1): 122–6.
77. Han J, Wu S, Fan Y, Tian Y, Kong J. Biliary Microbiota in Choledocholithiasis and Correlation With Duodenal Microbiota. Front Cell Infect Microbiol. 2021; 11: 625589.
78. Lyu Z, Yu T, Zhang L, Xu X, Zhang Y, Li J, et al. Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones. Synth Syst Biotechnol. 2021 Dec; 6 (4): 414–28.
79. Ye C, Zhou W, Zhang H, Miao L, Lv G. Alterations of the Bile Microbiome in Recurrent Common Bile Duct Stone. BioMed Res Int. 2020; 2020: 4637560.
80. Wu KQ, Sun WJ, Li N, Chen YQ, Wei YL, Chen DF. Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly Prevotella abundance. Scand J Gastroenterol. 2019 Dec; 54 (12): 1419–25.
81. Lee SM, Kim N, Yoon H, Kim YS, Choi SI, Park JH, et al. Compositional and Functional Changes in the Gut Microbiota in Irritable Bowel Syndrome Patients. Gut Liver. 2021 Mar 15; 15 (2): 253–61.
82. Tap J, Derrien M, Törnblom H, Brazeilles R, Cools-Portier S, Doré J, et al. Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome. Gastroenterology. 2017 Jan; 152 (1): 111–123.e8.
83. Ramos Meyers G, Samouda H, Bohn T. Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability. Nutrients. 2022 Dec 16; 14 (24): 5361.
84. Rodiño-Janeiro BK, Vicario M, Alonso-Cotoner C, Pascua-García R, Santos J. A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies. Adv Ther. 2018; 35 (3): 289–310.
85. Olvera-Rosales LB, Cruz-Guerrero AE, Ramírez-Moreno E, Quintero-Lira A, Contreras-López E, Jaimez-Ordaz J, et al. Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics. Foods. 2021 Jun 2; 10 (6): 1261.
86. Shi Q, Yuan X, Zeng Y, Wang J, Zhang Y, Xue C, et al. Crosstalk between Gut Microbiota and Bile Acids in Cholestatic Liver Disease. Nutrients. 2023 May 22; 15 (10): 2411.
87. Binda C, Gibiino G, Coluccio C, Sbrancia M, Dajti E, Sinagra E, et al. Biliary Diseases from the Microbiome Perspective: How Microorganisms Could Change the Approach to Benign and Malignant Diseases. Microorganisms. 2022 Jan 28; 10 (2): 312.
88. Roszkowska P, Klimczak E, Ostrycharz E, Rączka A, Wojciechowska-Koszko I, Dybus A, et al. Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Related Diseases-Current State of Knowledge. Biomedicines. 2024 May 7; 12 (5): 1030.
89. Montoro-Huguet MA, Belloc B, Domínguez-Cajal M. Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients. 2021 Apr 11; 13 (4): 1254.
90. Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, De Timary P, et al. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans. Gut Microbes. 12 (1): 1782157.
91. Fitriakusumah Y, Lesmana CRA, Bastian WP, Jasirwan COM, Hasan I, Simadibrata M, et al. The role of Small Intestinal Bacterial Overgrowth (SIBO) in Non-alcoholic Fatty Liver Disease (NAFLD) patients evaluated using Controlled Attenuation Parameter (CAP) Transient Elastography (TE): a tertiary referral center experience. BMC Gastroenterol. 2019 Mar 20; 19: 43.
92. Anand S, Mande SS. Host-microbiome interactions: Gut-Liver axis and its connection with other organs. NPJ Biofilms Microbiomes. 2022 Nov 1; 8 (1): 89.
93. Liu P, Jin M, Hu P, Sun W, Tang Y, Wu J, et al. Gut microbiota and bile acids: Metabolic interactions and impacts on diabetic kidney disease. Curr Res Microb Sci. 2024; 7: 100315.
94. Jia M, Fan Y, Ma Q, Yang D, Wang Y, He X, et al. Gut microbiota dysbiosis promotes cognitive impairment via bile acid metabolism in major depressive disorder. Transl Psychiatry. 2024 Dec 24; 14 (1): 503.
95. Salimi A, Sepehr A, Ajdarkosh H, Aghamohammad S, Talebi M, Rohani M, et al. Dynamic Population of Gut Microbiota as an Indicator of Inflammatory Bowel Disease. Iran Biomed J. 2022 Sep; 26 (5): 350–6.
96. Kumar A, Pramanik J, Goyal N, Chauhan D, Sivamaruthi BS, Prajapati BG, et al. Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options. Pharmaceuticals. 2023 Apr 9; 16 (4): 565.
97. Simpson CA, Diaz-Arteche C, Eliby D, Schwartz OS, Simmons JG, Cowan CSM. The gut microbiota in anxiety and depression – A systematic review. Clin Psychol Rev. 2021 Feb; 83: 101943.
98. You W, Zhu Y, Wei A, Du J, Wang Y, Zheng P, et al. Traumatic Brain Injury Induces Gastrointestinal Dysfunction and Dysbiosis of Gut Microbiota Accompanied by Alterations of Bile Acid Profile. J Neurotrauma. 2022 Jan; 39 (1–2): 227–37.
99. Raygoza Garay JA, Turpin W, Lee SH, Smith MI, Goethel A, Griffiths AM, et al. Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives. Gastroenterology. 2023 Sep; 165 (3): 670–81.
100. Жиленко В. Ю. Исследование резистентности молочнокислых бактерий с пробиотическими свойствами / В. Ю. Жиленко, О. В. Куприян // Рациональное использование природных ресурсов и переработка техногенного сырья: фундаментальные проблемы науки, материаловедение, химия и биотехнология: Материалы Международной научной конференции, Алушта-Белгород, 30 мая – 03июня 2022 года. Белгород: Белгородский государственный технологический университет им. В. Г. Шухова, 2022.С. 401–405. – EDN DFVNJR.
101. Славко Е. А. Применение синбиотиков в комплексной терапии заболеваний с синдромом избыточного бактериального роста. Е. А. Славко, А. Е. Желдыбаева. Лечение и профилактика. 2022; 12 (4): 85–89. EDN ADDZAH.
102. Трухан Д. И., Викторова И. А., Иванова Д. С. Синдром диареи в реальной клинической практике: актуальные аспекты дифференциальной диагностики и коррекции. Терапия. 2020; 2: 145–155. dhttps://dx.doi.org/10.18565/therapy.2020.2.145–155.
103. Ардатская М. Д., Анучкин А. А., Буторова Л. И., Павлов А. И., Нугаева Н. Р., Фадина Ж. В. Патогенетические аспекты развития и лечения антибиотик-ассоциированной диареи: выбор синбиотика с позиции доказательной медицины. Медицинский совет. 2023; 17 (6): 113–125. https://doi.org/10.21518/ms2023–026
104. Rijkers G. T., Bengmark S., Enck P., Haller D., Herz U., Kalliomaki M. et al. Guidance for substantiating the evidence for beneficial effects of probiotics: current status and recommendations for future research. J Nutr. 2010; 140 (3): 671S–676S. https://doi.org/10.3945/jn.109.113779
Рецензия
Для цитирования:
Котляров С.Н., Шелухина С.В., Маркова Е.В., Бутов М.А., Василевская А.С. Особенности микробиоты кишечника при заболеваниях желчевыводящих путей. Медицинский алфавит. 2025;(6):13-20. https://doi.org/10.33667/2078-5631-2025-6-13-20
For citation:
Kotlyarov S.N., Sheloukhina S.V., Markova E.V., Butov M.A., Vasilevskaya A.S. Features of gut microbiota in diseases of the biliary tract. Medical alphabet. 2025;(6):13-20. (In Russ.) https://doi.org/10.33667/2078-5631-2025-6-13-20
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