

Clinical Testing of a Clinical Decision Support System Integrated into a Medical Information System in a Therapeutic Dentistry Clinic
https://doi.org/10.33667/2078-5631-2025-10-118-125
Abstract
As part of this research, an intelligent clinical decision support system was developed to enhance the diagnostic efficiency of oral mucosal diseases. Following manual modeling of graph-based representations of oral mucosal diseases and development of disease prediction and diagnostic modules using algorithmic methods, the intelligent clinical decision support system underwent testing. For clinical validation, the CDSS was integrated into healthcare information systems of medical institutions and made accessible via smartphone and computer screens. The study involved evaluation of clinical, laboratory, and instrumental patient data.
Objective. Clinical validation of a Clinical Decision Support System integrated with a Medical Information System in a therapeutic dentistry clinic.
Materials and methods. Retrospective analysis of medical records of patients with oral mucosal diseases, prospective study of patients with oral mucosal conditions, Clinical Decision Support System.
Results. Clinical validation of the Clinical Decision Support System was successfully conducted in a therapeutic dentistry clinic.
Conclusions: The clinical validation demonstrated the CDSS’s capability to: extract symptoms with 91.8% accuracy, establish preliminary diagnosis with 84.7% accuracy, determine final diagnosis based on analysis of additional diagnostic methods with 94.6% accuracy.
About the Authors
E. G. MargaryanRussian Federation
Margaryan Edita Garnikovna – MD, Professor of the Department of Therapeutic Dentistry,
Moscow
G. A. Bledzhyants
Russian Federation
Bledzhyants Gevorg Armenakovich – cardiovascular surgeon, senior researcher,
Moscow
A. G. Kadzhoian
Russian Federation
Kadzhoian Armine Gurgenovna – Postgraduate student of the Department of Therapeutic Dentistry,
Moscow
A. K. Salpakova
Russian Federation
Sapakova Amina Kamzaevna – MD,
Moscow
Yu. S. Kurenkova
Russian Federation
Kurenkova Yuliya Sergeevna – Postgraduate student of the Department of Therapeutic Dentistry,
Moscow
M. T. Abdelrahim
Russian Federation
Abdelrakhim Mari Tarekovna – Postgraduate student of the Department of Therapeutic Dentistry,
Moscow
K. D. Davletova
Russian Federation
Davletova Kamila Dlyaverovna, Postgraduate student of the Department of Therapeutic Dentistry,
Moscow
M. K. Makeeva
Russian Federation
Makeeva Mariya Konstantinovna, Ph.D,
Moscow
K. V. Lalayan
Armenia
Lalayan Karen Vladimirovich – MD, Professor of the Department of Surgical Stomatology and Maxillofacial surgery,
Yerevan
Huiping Tan
China
Tan Huiping – Head of the Integrated Department of the Russian-Chinese Center for Medical Research,
Harbin
Pan Shuan
China
Shuan Pan – Pan Shuang, Professor,
Harbin
References
1. Diseases of the lips and tongue in children. Etiology, clinical manifestations, diagnostics and treatment of diseases of the lips and tongue in childhood. – Text: electronic // Belarusian State Medical Institute: [website]. – URL: https://www.bsmu.by/downloads/kafedri/k_detstom/stud/4.pdf (date of access: 18.04.2023).
2. Denisova M.A. Clinical and functional substantiation of photodynamic therapy of chronic lip diseases: specialty 14.01.14 «Dentistry»: abstract of a dissertation for the degree of candidate of medical sciences / Denisova Maria Anatolyevna; Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of the Russian Federation. – Moscow, 2016. – 150 p.
3. Kadzhoyan A.G., Komogortseva V.E., Margaryan E. Monitoring the diagnosis of diseases of the oral mucosa by dentists taking into account their professional status. New in dentistry: organization, clinic, economics // Materials of the Annual scientific-practical conference of dentists of the Federal Medical and Biological Agency of Russia. Moscow: 2021 – 128 p.
4. Kadzhoyan A. G., Margaryan E. G. Justification for the development and clinical application of a system for supporting medical decision-making in the diagnosis of diseases of the oral mucosa // Collection of scientific articles based on the results of the International Scientific Forum Science and Innovation – Modern Concepts (Moscow, March 12, 2021). / ed. D. R. Khismatullin. – Moscow: Infinity Publishing House, 2021. – p. 95.
5. Kadzhoyan A.G., Margaryan E.G., Digital systems for supporting medical decision-making at a dental appointment for diseases of the oral mucosa//Collection of articles of the IV Scientific and Practical Conference «Scientific Avant-garde» and the Interuniversity Olympiad of Residents and Postgraduates-M.: Federal State Budgetary Institution of the State Scientific Center FMBC named after A.I. Burnazyan FMBA of Russia, 2022-20 p.
6. Clinical protocols of the Ministry of Health of the Republic of Kazakhstan – 2016 (Kazakhstan). Rossolimo-Melkersson syndrome. – Text: electronic // MedElement: [site]. – URL: https://diseases.medelement.com/ (date of access: 18.04.2023).
7. Therapeutic dentistry. In 3 parts. Part 3. Diseases of the oral mucosa: textbook / Ed. G.M. Barer – 2nd ed., supplemented and revised. – Moscow: GEOTAR-Media, 2015. – 256 p.
8. E.G. Margaryan, A.G. Kadzhoyan, N.E. Novozhilova, A.V. Atanesyan, V.E. Komogortseva, G. A. Bledzhyants, The need for systems to support medical decision-making in diagnosing diseases of the oral mucosa. Medical alphabet. 2022. No. 7. P. 31
9. Bakshi S.S. Melkersson-Rosenthal Syndrome / S. S. Bakshi.– Текст : непосредственный// The Journal of Allergy and Clinical Immunology. – 2017. – № 5(2). – С. 471–472.
10. Girijala, R. L. Exfoliative Cheilitis as a Manifestation of Factitial Cheilitis / R. L. Girijala, R. Falkner, S. R. Dalton, B. D. Martin. // Cureus. – 2018. – № 10(5). – е2565
11. Kadzhoyan A.,Esayan M.,Margaryan E. Artificial intelligence in dentistry: application and effectiveness. International independent scientific journal, No 28, 2021.
12. Kuang W. Research progress on Melkersson-Rosenthal syndrome / W. Kuang, X. Luo, J. Wang, X. Zeng. – Текст : непосредственный // Zhejiang Da Xue Xue Bao Yi Xue Ban. – 2021. – № 50(2). – С. 148–154.
13. Levi A. Daylight photodynamic therapy for the treatment of actinic cheilitis / A. Levi, E. Hodak, C. D. Enk [и др.]. // Photodermatology, Photoimmunology & Photomedicine. – 2019. – № 35(1). – С. 11–16.
14. Lugović-Mihić L. Differential Diagnosis of Cheilitis – How to Classify Cheilitis? / L. Lugović-Mihić, K. Pilipović, I. Crnarić [и др.]. – Текст : непосредственный // Acta Clinica Croatica. – 2018. – № 57(2). – С. 342–351.
15. Oza, N. Angular cheilitis: A clinical and microbial study / N. Oza, J. J. Doshi. – Текст: непосредственный // Indian Journal of Dental Research. – 2017. – № 28(6). – С. 661–665.
Review
For citations:
Margaryan E.G., Bledzhyants G.A., Kadzhoian A.G., Salpakova A.K., Kurenkova Yu.S., Abdelrahim M.T., Davletova K.D., Makeeva M.K., Lalayan K.V., Tan H., Shuan P. Clinical Testing of a Clinical Decision Support System Integrated into a Medical Information System in a Therapeutic Dentistry Clinic. Medical alphabet. 2025;(10):118-125. (In Russ.) https://doi.org/10.33667/2078-5631-2025-10-118-125