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Dynamics of rheological properties of oral fluid in patients with primary hypothyroidism during the use of a targeted biocorrection drug and a composition based on lactoferrin
E. Yu. Bushueva,
S. S. Grigoriev,
A. N. Kozmenko,
E. N. Svetlakova,
A. A. Dregalkina,
A. S. Plotnikov https://doi.org/10.33667/2078-5631-2025-10-34-38
Abstract
Primary hypothyroidism is a clinical syndrome that develops as a result of a persistent deficiency of thyroid hormones or a decrease in their biological effect at the tissue level and is often accompanied by changes in the structure and function of the large and small salivary glands, which in turn can lead to the development of dry mouth (xerostomia). Disruption of the salivary glands creates favorable conditions for the development of dental diseases in the oral cavity of various etiologies.
Materials and methods. The study involved 90 women with a main diagnosis of primary hypothyroidism, aged 44–59, receiving hormone replacement therapy. All patients were randomized into groups depending on the therapy received. All patients were assessed for the rate of salivation, pH level and viscosity of the oral fluid at the initial stage of the study and during the follow-up period (3, 6,12 months).
Results. The study of the results of the assessment of the rheological properties of oral fluid showed that, unlike Group 1, statistically significant differences were obtained in Groups 2 and 3 between the beginning of the study and the end of the dynamic observation period. In Group 3, the changes were more stable.
Conclusions. The use of targeted biocorrection drugs and a lactoferrin-based composition in patients with primary hypothyroidism made it possible to normalize the rate of salivation, pH and viscosity of oral fluid in patients with primary hypothyroidism in the immediate and long-term observation periods.
About the Authors
E. Yu. Bushueva
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Bushueva Elizaveta Yu. – assistant of the department of therapeutic dentistry and
propaedeutics,
Yekaterinburg
S. S. Grigoriev
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Grigoriev Sergey S. – MD, Professor, Head of the Department of Therapeutic Dentistry
and Propaedeutics of Dental Diseases,
Yekaterinburg
A. N. Kozmenko
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Kozmenko Anastasia N. – PhD, Associate Professor of the Department of Therapeutic
Dentistry and Propaedeutics of Dental Diseases,
Yekaterinburg
E. N. Svetlakova
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Svetlakova Elena N. – MD, Associate Professor of the Department of Therapeutic Dentistry
and Propaedeutics of Dental Diseases,
Yekaterinburg
A. A. Dregalkina
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dregalkina Anna A. – PhD, Associate Professor of the Department of Surgical Dentistry,
Otolaryngology and Maxillofacial Surgery,
Yekaterinburg
A. S. Plotnikov
Ural State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Plotnikov Alexandr S. – Assistant of the Department of Pediatric Dentistry and Orthodontics,
Yekaterinburg
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Review
For citations:
Bushueva E.Yu., Grigoriev S.S., Kozmenko A.N., Svetlakova E.N., Dregalkina A.A., Plotnikov A.S. Dynamics of rheological properties of oral fluid in patients with primary hypothyroidism during the use of a targeted biocorrection drug and a composition based on lactoferrin. Medical alphabet. 2025;(10):34-38. (In Russ.) https://doi.org/10.33667/2078-5631-2025-10-34-38
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