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A new perspective on wound healing mechanisms from the perspective of theory and practice
D. A. Eremin,
N. M. Krasnov,
N. M. Khelminskaya,
E. E. Faustova,
A. V. Posadskaya,
V. I. Kravetz,
P. A. Shen,
I. A. Nikolskaya https://doi.org/10.33667/2078-5631-2025-1-13-17
Abstract
The paper comprises information on the main processes of molecular-cellular interaction occurring in the wound during its healing. The main stages with their inherent sequence of molecular events that can affect the quality of wound healing, including in the long term, are reflected in the article. The data described give an idea of the most relevant areas for the study of wound healing mechanisms that are of practical importance for specialists dealing with this problem. The experienced authors of the paper deal in their practice with issues of effective impact on wound healing parameters with restoration of unctional and metabolic parameters of the damaged tissue.
About the Authors
D. A. Eremin
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dmitry Anatolyevich Eremin, PhD, Associate Professor of the Department of Maxillofacial Surgery and Dentistry
N. M. Krasnov
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Krasnov Nikolay Mikhailovich, Assistant of the Department of Maxillofacial Surgery, Institute of Dentistry
N. M. Khelminskaya
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Natalia Mikhailovna Helminskaya, MD, Professor of the Department of Maxillofacial Surgery and Dentistry
E. E. Faustova
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ekaterina E. Faustova, PhD, Associate Professor of the Department of Maxillofacial Surgery, Institute of Dentistry
A. V. Posadskaya
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Alexandra Vladimirovna Posadskaya, PhD, Associate Professor of the Department of Maxillofacial Surgery and Dentistry
V. I. Kravetz
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Viktor Ivanovich Kravets, PhD, Associate Professor of Maxillofacial Surgery and Dentistry
P. A. Shen
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Pavel Anatolyevich Shen, Assistant of the Department of Maxillofacial Surgery, Institute of Dentistry
I. A. Nikolskaya
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Nikolskaya Irina Andreevna, PhD, Associate Professor of the Department of Therapeutic Dentistry, Faculty of Dentistry
References
1. Sen C.K. HumanWound and Its Burden: Updated 2020 Compendium of Estimates. Adv. Wound Care 2021, 10, 281–292. [CrossRef][PubMed]
2. Bacci S. Cellular Mechanisms and Therapies in Wound Healing: Looking toward the Future. Biomedicines 2021, 9, 1611. [CrossRef][PubMed]
3. Grandi V.; Corsi A.; Pimpinelli, N.; Bacci, S. Cellular Mechanisms in Acute and Chronic Wounds after PDT Therapy: An Update.Biomedicines 2022, 10, 1624. [CrossRef] [PubMed]
4. Fernбndez-Guarino, M.; Hernбndez-Bule, M.L.; Bacci, S. Cellular and Molecular Processes in Wound Healing. Biomedicines 2023,11, 2526. [CrossRef]
5. Tyavambiza C.; Meyer M.; Meyer S. Cellular and Molecular Events of Wound Healing and the Potential of Silver Based Nanoformulations as Wound Healing Agents. Bioengineering 2022, 9, 712. [CrossRef]
6. Raziyeva K.; Kim Y.; Zharkinbekov Z.; Kassymbek K.; Jimi S.; Saparov, A. Immunology of Acute and Chronic Wound Healing. Biomolecules 2021, 11, 700. [CrossRef]
7. Rodrigues M.; Kosaric N.; Bonham C.A.; Gurtner, G.C. Wound Healing: A Cellular Perspective. Physiol. Rev. 2019, 99, 665–706. [CrossRef]
8. Wilkinson H.N.; Hardma M.J.Wound healing: Cellular mechanisms and pathological outcomes. Open Biol. 2020, 10, 200223. [CrossRef] [PubMed]
9. Fernбndez-Guarino M.; Hernбndez-Bule M.L.; Bacci S. Cellular and Molecular Processes in Wound Healing. Biomedicines 2023,11, 2526. [CrossRef]
10. Huang C.; Ogawa, R. Keloidal pathophysiology: Current notions. Scars Burn. Heal. 2021, 7, 2059513120980320. [CrossRef]
11. Barone N.; Safran T.; Vorstenbosch J.; Davison P.G.; Cugno S.; Murphy A.M. Current Advances in Hypertrophic Scar andKeloid Management. Semin. Plast. Surg. 2021, 35, 145–152. [CrossRef]
12. Limandjaja G.C.; Niessen F.B.; Scheper R.J.; Gibbs S. The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models. Front. Cell Dev. Biol. 2020, 8, 360. [CrossRef]
13. Berman, B.; Maderal, A.; Raphael, B. Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment. Dermatol.Surg. 2017, 43 (Suppl. 1), S3–S18. [CrossRef]
14. Andrews J.P.; Marttala J.; Macarak E.; Rosenbloom, J.; Uitto, J. Keloids: The paradigm of skin fibrosis – Pathomechanisms andtreatment. Matrix Biol. 2016, 51, 37–46. [CrossRef]
15. Glass D.A. Current Understanding of the Genetic Causes of Keloid Formation. J. Investig. Dermatol. Symp. Proc. 2017, 18, S50–S53.[CrossRef]
16. Kim H.J.; Kim Y.H. Comprehensive Insights into Keloid Pathogenesis and Advanced Therapeutic Strategies. Int. J. Mol. Sci.2024, 25, 8776. [CrossRef]
17. Libersky S.; Marczak D.; Migdalski A. The influence of genetic factors on the pathogenesis of hypertrophic scars and keloids. J.Educ. Health Sport 2018, 8, 313–321.
18. Sadiq A.; Khumalo N.P.; Bayat A. Genetics of Keloid Scarring. In Textbook on Scar Management: State of the Art Management andEmerging Technologies; Tйot L., Mustoe T.A., Middelkoop E., Gauglitz G.G., Eds.; Springer: Cham, Switzerland, 2020; Chapter 8.Available online: https://www.ncbi.nlm.nih.gov/books/ NBK586075/ (accessed on 10 November 2024).
19. Ogawa R. Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. Int. J. Mol. Sci. 2017, 18, 606. [CrossRef] [PubMed]
20. Choi, C.; Mukovozov, I.; Jazdarehee, A.; Rai, R.; Sachdeva, M.; Shunmugam, M.; Zaslavsky, K.; Byun, S.; Barankin, B. Management of hypertrophic scars in adults: A systematic review and meta-analysis. Australas. J. Dermatol. 2022, 63, 172–189. [CrossRef] [PubMed]
21. Lingzhi Z.; Meirong L.; Xiaobing F. Biological approaches for hypertrophic scars. Int. Wound J. 2020, 17, 405–418. [CrossRef][PubMed]
22. Mony M.P.; Harmon K.A.; Hess R.; Dorafshar A.H.; Shafikhani S.H. An Updated Review of Hypertrophic Scarring. Cells 2023, 12, 678. [CrossRef] [PubMed]
Review
For citations:
Eremin D.A., Krasnov N.M., Khelminskaya N.M., Faustova E.E., Posadskaya A.V., Kravetz V.I., Shen P.A., Nikolskaya I.A. A new perspective on wound healing mechanisms from the perspective of theory and practice. Medical alphabet. 2025;(1):13-17. (In Russ.) https://doi.org/10.33667/2078-5631-2025-1-13-17
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