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Reference TSH intervals in children and adolescents
https://doi.org/10.33667/2078-5631-2024-20-42-45
Abstract
The determination of thyroid-stimulating hormone (TSH) is a reliable test in the diagnosis of thyroid dysfunction. When interpreting the results of quantitative studies, clinicians and laboratory specialists most often resort to assessing the compliance of the result with reference intervals (RI). At the same time, each laboratory must determine them for the analytes being measured itself, based on the characteristics of the examined contingent, the characteristics of the analytical systems used, achieving the necessary diagnostic effectiveness of the methodology, and its own practical and economic capabilities. A retrospective analysis of TSH results obtained from patients under the age of 19 years was performed for 54970 patients without hypothyroidism, thyrotoxicosis and pituitary disorders. For this work, reagent kits “Roche Cobas”, “Mindray” and “Beckman Coulter” (ICLA) were used. As a result, RI was established for the study of TSH for three sets of reagents with appropriate equipment and for four age groups: 1 day – 6 months, 6 months – 7 years, 7–14 years, 14–19 years. This makes it possible to use RI as a screening for possible developmental pathology in childhood and to determine the limits of clinical decisions.
About the Authors
V. S. Kuznetsova
Clinical Hospital No.52 of the Moscow City Health Department
Russian Federation
Russian Federation
Kuznetsova Veronika S. - clinical laboratory diagnostics physician.
Moscow
O. A. Efimushkina
Clinical Hospital No.52 of the Moscow City Health Department
Russian Federation
Russian Federation
Efimushkina Oksana A. - PhD Med, head of Diagnostic Clinical Laboratory, clinical laboratory diagnostics physician.
Moscow
V. P. Mudrov
Clinical Hospital No.52 of the Moscow City Health Department; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Mudrov Valery P. - DM Sci (habil.), clinical laboratory diagnostics physician CHNo.52 of the Moscow City Health Department, assistant at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology RMACPE.
Moscow
I. S. Shumilkina
Diagnostic Clinical Center No.1 of the Moscow City Health Department
Russian Federation
Russian Federation
Shumilkina Irina A. - PhD Med, head of Dept of Medical Prevention DCC No.1 of the Moscow City Health Department, general practitioner, gastroenterologist.
Moscow
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Review
For citations:
Kuznetsova V.S., Efimushkina O.A., Mudrov V.P., Shumilkina I.S. Reference TSH intervals in children and adolescents. Medical alphabet. 2024;(20):42-45. (In Russ.) https://doi.org/10.33667/2078-5631-2024-20-42-45
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