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Long-term effects of radiation therapy in outpatient practice
https://doi.org/10.33667/2078-5631-2024-13-34-41
Abstract
Moscow multidisciplinary clinical center «Kommunarka», Moscow, Russia SUMMARY Radiation therapy is one of the main methods of treating malignant neoplasms. Along with high efficiency, radiation therapy leads to complications in the early and late period. General practitioners and therapists are insufficiently familiar with long-term radiation-induced complications. The article presents data on the pathogenesis, clinical manifestations, diagnosis and treatment of radiation lesions of the bone system, lungs, myocardium, gastrointestinal tract, genitourinary system, hematopoiesis system, as well as chronic pain syndrome. The symptoms of late complications of radiation therapy are nonspecific and similar to the symptoms of somatic diseases. Knowledge of the clinical manifestations of radiation-induced complications in the long term allows timely diagnosis and treatment.
About the Authors
N. D. Karseladze
Medical Center of the Airport of the MOW
Russian Federation
Russian Federation
Karseladze Natalia D. - PhD Med, general practitioner.
Moscow
O. A. Tiganova
Pirogov Russian National Research Medical University, Ministry of Healthcare of Russia; Morozovskaya Children`s City Clinical Hospital of the Department of Health of the City of Moscow
Russian Federation
Russian Federation
Tiganova Olga A. - PhD Med, associate professor, staff of the State Academy of Pediatrics Pirogov RNRMU, pediatric oncologist-hematologist Morozovskaya Children`s CC H of the Department of Health of the City of Moscow.
Moscow
L. I. Ilyenko
Pirogov Russian National Research Medical University, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Ilyenko Lydia I. - DM Sci (habil.), professor, dean of the Faculty of Pediatrics, head of the Dept of Hospital Pediatrics No. 2 of the Faculty of Pediatric.
Moscow
N. V. Orlova
Pirogov Russian National Research Medical University, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Orlova Natalia V. - DM Sci (habil.), professor at the Dept of faculty therapy.
Moscow
S. Z. Danelyan
Moscow multidisciplinary clinical center «Kommunarka»
Russian Federation
Russian Federation
Danelyan Sonya Zh. - PhD Med, deputy chief physician for Obstetric and Gynecological Care.
Moscow
References
1. Thariat J, Hannoun-Levi JM, Sun Myint A, Vuong T, Gérard JP. Past, present, and future of radiotherapy for the benefit of patients. Nat. Rev. Clin. Oncol. 2013 Jan; 10 (1): 52–60. DOI: 10.1038/nrclinonc.2012.203
2. Jermann M. Particle therapy statistics in 2014. Int J. Particle. Ther. 2015; 2: 50–4.
3. Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF et al. SEER Cancer Statistics Review, 1975–2012, National Cancer Institute. Bethesda, MD. https://seer.cancer.gov/archive/csr/1975_2012.
4. Etschmaier V, Glänzer D, Eck N, Schäfer U, Leithner A, Georg D et al. Proton and Carbon Ion Irradiation Changes the Process of Endochondral Ossification in an Ex Vivo Femur Organotypic Culture Model. Cells. 2023 Sep 18; 12 (18): 2301. DOI: 10.3390/cells12182301
5. Dalinka MK, Edeiken J, Finkelstein JB. Complications of radiation therapy: adult bone. Semin Roentgenol. 1974 Jan; 9 (1): 29–40. DOI: 10.1016/0037–198x(74)90007–8
6. Rutherford H, Dodd GD. Complications of radiation therapy: growing bone. Semin Roentgenol. 1974 Jan; 9 (1): 15–27. DOI: 10.1016/0037–198x(74)90006–6
7. Huvos AG, Woodard HQ. Postradiation sarcomas of bone. Health Phys. 1988 Oct; 55 (4): 631–6. DOI: 10.1097/00004032–198810000–00004
8. Mitchell MJ, Logan PM. Radiation-induced changes in bone. Radiographics. 1998 Sep-Oct; 18 (5): 1125–36; quiz 1242–3. DOI: 10.1148/radiographics.18.5.9747611
9. Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS. Radiation dose-volume effects in the lung. Int J. Radiat. Oncol. Biol. Phys. 2010; 76: S 70–6. DOI: 10.1016/j.ijrobp.2009.06.091
10. Prasanna PGS, Aryankalayil M, Citrin DE, Coleman CN. Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs. Int J. Radiat. Biol. 2023; 99 (7): 1027–1036. DOI: 10.1080/09553002.2023.2177768
11. Wang J, Chen L, Chen B, Meliton A, Liu SQ, Shi Y, Liu T, Deb DK, Solway J, Li YC. Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis. Sci Rep. 2015 Oct 23; 5: 15561. DOI: 10.1038/srep15561
12. Jarzebska N., Karetnikova E. S. Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis/Pulmonary Medicine. 15 January 2021; 7: 2020. | https://doi.org/10.3389/fmed.2020.585756
13. Li X, Duan L, Yuan S, Zhuang X, Qiao T, He J. Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1. J. Inflamm (Lond). 2019 May 29; 16: 11. DOI: 10.1186/s12950–019–0216–0
14. Benveniste MF, Gomez D, Carter BW, Betancourt Cuellar SL, Shroff GS, Benveniste APA, Odisio EG, Marom EM. Recognizing Radiation Therapy-related Complications in the Chest. Radiographics. 2019 Mar-Apr; 39 (2): 344–366. DOI: 10.1148/rg.2019180061. PMID: 30844346.
15. Cheng YJ, Nie XY, Ji CC, Lin XX, Liu LJ, Chen XM, Yao H, Wu SH. Long-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer. J. Am. Heart. Assoc. 2017 May 21; 6 (5): e005633. DOI: 10.1161/JAHA.117.005633
16. Cuomo JR, Sharma GK, Conger PD, Weintraub NL. Novel concepts in radiation-induced cardiovascular disease. World J. Cardiol. 2016 Sep 26; 8 (9): 504–519. DOI: 10.4330/wjc.v8.i9.504
17. Veinot JP, Edwards WD. Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases. Hum Pathol. 1996 Aug; 27 (8): 766–73. DOI: 10.1016/s0046–8177(96)90447–5
18. Iyer RB, Balachandran A, Bruzzi JF, Johnson V, Macapinlac HA, Munden RF. PET/ CT and hepatic radiation injury in esophageal cancer patients. Cancer Imaging. 2007 Nov 26; 7 (1): 189–94. DOI: 10.1102/1470–7330.2007.0027
19. Webb GJ, Brooke R, De Silva AN. Chronic radiation enteritis and malnutrition. J. Dig. Dis. 2013 Jul; 14 (7): 350–7. DOI: 10.1111/1751–2980.12061
20. Klaus R, Niyazi M, Lange-Sperandio B. Radiation-induced kidney toxicity: molecular and cellular pathogenesis. Radiat. Oncol. 2021 Feb 25; 16 (1): 43. DOI: 10.1186/s13014–021–01764-y
21. Marci R, Mallozzi M, Di Benedetto L, Schimberni M, Mossa S, Soave I, Palomba S, Caserta D. Radiations and female fertility. Reprod. Biol. Endocrinol. 2018 Dec 16;1 6 (1): 112. DOI: 10.1186/s12958–018–0432–0. PMID: 30553277.
22. Whang-Peng J, Knutsen T, O’Donnell JF, Brereton HD. Acute non-lymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-Hodgkin’s lymphoma and chronic lymphocytic leukemia: cytogenetic studies. Cancer. 1979 Nov; 44 (5): 1592–600. DOI: 10.1002/1097–0142(197911)44:5<1592::aid-cncr2820440509>3.0.co;2-a
23. Sun LM, Lin CL, Lin MC, Liang JA, Kao CH. Radiotherapy- and chemotherapy-induced myelodysplasia syndrome: a nationwide population-based nested case-control study. Medicine (Baltimore). 2015 May; 94 (17): e737. DOI: 10.1097/MD.0000000000000737
24. Chua GWY, Vig PS. Overview of radiotherapy-induced chronic pain in childhood cancer survivors: A narrative review. Paediatr. Neonatal. Pain. 2023 Feb 2; 5 (1): 1–9. DOI: 10.1002/pne2.12094
Review
For citations:
Karseladze N.D., Tiganova O.A., Ilyenko L.I., Orlova N.V., Danelyan S.Z. Long-term effects of radiation therapy in outpatient practice. Medical alphabet. 2024;(13):34-41. (In Russ.) https://doi.org/10.33667/2078-5631-2024-13-34-41
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