Effectiveness of new synthesized analogue of endogenous peptide taftcin - Selank in therapy of adjustment and posttraumatic stress disorders
Abstract
The effectiveness of the new regulatory peptide Selank®, synthesized analogue of the endogenous peptide taftcin was studied for the treatment adjustment disorder. There were clarifications its clinical properties as emotional stabilizer. Clinical manifestations of adjustment disorder n disorders were studied in 577 people, age categories 21-34 years (153 people), 35-50 years (257 people), 51-65 years (167 people) using the PHQ questionnaire. The results of the study were demonstrated the prevalence individual stress related with unemployment or loss of work and a subjective deterioration in all age groups. These symptoms were increased to 50.9% in the 51-65 years age group. Selank® therapy (0.15 %) was performed in 30 patients (18 women and 12 men) with adjustment disorders during 14 days. Selank® had the corrective effects. The corrective effects of the regulatory peptide Selank® were revealed for somatic and mental symptoms of the adjustment disorder. The results of the study confirmed, that the Selank® has stress-protective effect. The effectiveness of the regulatory peptide Selank® persisted after the drug discontinuation. The study demonstrated the effectiveness of Selank® in the pharmacological treatment the adjustment disorder and good clinical tolerability. Recommendations of the complex treatments were proposed for adjustment disorder, posttraumatic stress disorder.
About the Authors
V. A. Verbenko
Crimean Federal University n. a. V. I. Vernadsky
Russian Federation
Russian Federation
T. A. Shakina
Peptogen Co
Russian Federation
Russian Federation
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For citations:
Verbenko V.A., Shakina T.A. Effectiveness of new synthesized analogue of endogenous peptide taftcin - Selank in therapy of adjustment and posttraumatic stress disorders. Medical alphabet. 2017;3(32):21-26. (In Russ.)
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