Химиотерапия с включением доксорубицина, ифосфамида при распространенной злокачественной гломусной опухоли мягких тканей предплечья (клинический случай и обзор литературы)

Злокачественная гломусная опухоль представляет собой крайне редкое и агрессивное новообразование, состоящие из модифицированных клеток гломусного тела. Постановка верного морфологического диагноза затруднительна и требует тщательной дифференциальной диагностики между нейроэндокринными опухолями, перицитарными опухолями, новообразованиями гладкой мускулатуры. В литературе описаны лишь единичные клинические наблюдения, серии случаев и результаты небольшого количества ретроспективных исследований. В связи с редкостью нозологии оптимальной стратегии лечения данного заболевания не выработано. В большинстве случаев при местнораспространенном процессе применяется хирургическое лечение. Случаи метастазирования злокачественной гломусной опухоли встречаются крайне редко. Единого консенсуса по тактике системного лечения на сегодняшний день не достигнуто. В данной статье мы представляем клинический случай достижения стабилизации опухолевого процесса после проведения пяти курсов химиотерапии доксорубицином, ифосфамидом у 49-летнего пациента со злокачественной гломусной опухолью мягких тканей левого предплечья с метастатическим поражением тканей передней стенки грудной клетки слева с распространением на левую малую грудную мышцу, третье ребро и плевральную полость, с метастатическим поражением паренхимы легких.

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