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Case of severe liver damage in 12‑year‑old child with intentional overdose of paracetamol
S. S. Postnikov,
N. V. Teplova,
G. P. Brusov,
T. N. Komarova,
A. G. Rumyantsev,
I. N. Tatarova,
E. K. Donush,
E. A. Tsimbalova,
M. N. Kostyleva,
A. N. Gratsianskaya,
R. V. Libcis https://doi.org/10.33667/2078-5631-2023-18-28-33
Abstract
Currently, more than 1200 drugs of almost all pharmacological classes are known that can cause drug-induced liver injury (DILI). Antibacterial agents are responsible for almost half (45 %) of all DILI. In second place are psychotropic drugs and analgesics-antipyretics. And if DILI caused by antimicrobial drugs are unintentional and usually the result of an underestimation of drug pathology by doctors, then liver damage that occurs after taking psychotropic drugs or antipyretic analgesics, among which paracetamol stands out, is often the result of their deliberate use for suicidal purposes against the background of depression both in adults and in adolescents 12–17 years of age.
About the Authors
S. S. Postnikov
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Postnikov Sergey S., Dept of Clinical Pharmacology of Faculty of Medicine
Moscow
N. V. Teplova
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Teplova Natalya V., DM Sci (habil.), professor, associate professor, head of Dept of Clinical Pharmacology of Faculty of Medicine
Moscow
G. P. Brusov
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Bryusov Gleb P., Russian Children's Clinical Hospital
Moscow
T. N. Komarova
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Komarova Tatyana N., Russian Children’s Clinical Hospital
Moscow
A. G. Rumyantsev
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Russian Children's Clinical Hospital
Moscow
I. N. Tatarova
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Russian Children’s Clinical Hospital
Moscow
E. K. Donush
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Russian Children’s Clinical Hospital
Moscow
E. A. Tsimbalova
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Russian Children’s Clinical Hospital
Moscow
M. N. Kostyleva
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Dept of Clinical Pharmacology, Faculty of Medicine, Russian Children’s Clinical Hospital
Moscow
A. N. Gratsianskaya
Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Gratsianskaya Anna N., Dept of Clinical Pharmacology, Faculty of Medicine
Moscow
R. V. Libcis
French Dental Clinic
Russian Federation
Russian Federation
Libtsis Roman V., dentist-surgeon
Moscow
References
1. Bunchorntavakul C, Reddy KR. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 2013; 17 (4): 587–viii. DOI: 10.1016/j.cld.2013.07.005.
2. McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: Recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013; 30 (9): 2174–2187. DOI: 10.1007/s11095–013–1007–6.
3. Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J. 1966; 2 (5512): 497–499. DOI: 10.1136/bmj.2.5512.497.
4. Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity. Front Pharmacol. 2018; 9: 453. Published 2018 May 15. DOI: 10.3389/fphar.2018.00453.
5. Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-Induced Hepatotoxicity: A Comprehensive Update. J Clin Transl Hepatol. 2016; 4 (2): 131–142. DOI: 10.14218/jcth.2015.00052
6. Blieden M, Paramore LC, Shah D, Ben-Joseph R. A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert Rev Clin Pharmacol. 2014; 7 (3): 341–348. DOI: 10.1586/17512433.2014.904744.
7. Graudins A. Paracetamol poisoning in adolescents in an Australian setting: Not quite adults. Emergency Medicine Australasia [Internet]. Wiley; 2015 Mar 5; 27 (2): 139–44. Available from: http://dx.doi.org/10.1111/1742–6723.12373
8. Woolbright BL, Ramachandran A, McGill MR, et al. Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol. 2012; 111 (6): 417–425. DOI: 10.1111/j.1742–7843.2012.00931.x.
9. Hayden JC, Kelly L, McNicholas F. A clinician's guide to self-poisoning with paracetamol in youth: The what, when and why? Acta Paediatr. 2020; 109 (11): 2237–2242. DOI: 10.1111/apa.15414.
10. EASL clinical guidelines: drug-induced liver injury. Journal of hepatology 2019 vol. 70: 1222–1261
11. Cummings AJ, King ML, Martin BK. A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man. Br J Pharmacol Chemother. 1967; 29 (2): 150–157. DOI: 10.1111/j.1476–5381.1967.tb01948.x.
12. Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: A randomized controlled trial. JAMA. 2006; 296 (1): 87–93. DOI: 10.1001/jama.296.1.87.
13. Big Russian Encyclopedia of Medicines. Remedium. 2001.
14. Herndon CM, Dankenbring DM. Patient perception and knowledge of acetaminophen in a large family medicine service. J Pain Palliat Care Pharmacother. 2014; 28 (2): 109–116. DOI: 10.3109/15360288.2014.908993.
15. Dart RC, Bailey E. Does therapeutic use of acetaminophen cause acute liver failure? Pharmacotherapy. 2007; 27 (9): 1219–1230. DOI: 10.1592/phco.27.9.1219.
16. Xie Y, McGill MR, Dorko K, et al. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol. 2014; 279 (3): 266–274. DOI: 10.1016/j.taap.2014.05.010
17. Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: An updated review. Arch Toxicol. 2015; 89 (2): 193–199. DOI: 10.1007/s00204–014–1432–2.
18. Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev. 2012; 44 (1): 88–106. DOI: 10.3109/03602532.2011.602688.
19. Molleston JP, Fontana RJ, Lopez MJ, et al. Characteristics of idiosyncratic drug-induced liver injury in children: Results from the DILIN prospective study. J Pediatr Gastroenterol Nutr. 2011; 53 (2): 182–189. DOI: 10.1097/mpg.0b013e31821d6cfd.
20. Maclaren R. Hepatic and cholestatic diseases. Drug-induced diseases. Prevention, detection and management. Bethesda, 2010; chapter 40, p. 771–800.
21. Markova I. V., Kalinicheva V. I. Pediatric pharmacology. Medicine. Leningrad 1987.
22. Andrade RJ, Lucena MI, Kaplowitz N, et al. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006; 44 (6): 1581–1588. DOI: 10.1002/hep.21424.
23. Gulati K, Reshi MR, Rai N, Ray A. Hepatotoxicity: Its Mechanisms, Experimental Evaluation and Protective Strategies. Am J Pharmacol. 2018; 1 (1): 1004.
24. Abboud G, Kaplowitz N. Drug-induced liver injury. Drug Saf. 2007; 30 (4): 277–294. DOI: 10.2165/00002018–200730040–00001.
25. de Abajo FJ, Montero D, Madurga M, García Rodríguez LA. Acute and clinically relevant drug-induced liver injury: A population-based case-control study. Br J Clin Pharmacol. 2004; 58 (1): 71–80. DOI: 10.1111/j.1365–2125.2004.02133.x.
26. Rumack BH, Peterson RG. Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients. Pediatrics. 1978; 62 (5 Pt 2 Suppl): 898–903.
27. Rossi S, Assis DN, Awsare M, et al. Use of over-the-counter analgesics in patients with chronic liver disease: Physicians' recommendations. Drug Saf. 2008; 31 (3): 261–270. DOI: 10.2165/00002018–200831030–00007.
Review
For citations:
Postnikov S.S., Teplova N.V., Brusov G.P., Komarova T.N., Rumyantsev A.G., Tatarova I.N., Donush E.K., Tsimbalova E.A., Kostyleva M.N., Gratsianskaya A.N., Libcis R.V. Case of severe liver damage in 12‑year‑old child with intentional overdose of paracetamol. Medical alphabet. 2023;(18):28-33. (In Russ.) https://doi.org/10.33667/2078-5631-2023-18-28-33
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