Случай тяжелого поражения печени у ребенка 12 лет при намеренной передозировке парацетамола

В настоящее время известно более 1200 лекарственных средств почти всех фармакологических классов, способных вызывать лекарственные поражения печени (ЛПП). Антибактериальные средства являются причиной почти половины (45 %) всех ЛПП. На втором месте находятся психотропные средства и анальгетики-антипиретики. И если ЛПП, обусловленные антимикробными препаратами, являются непреднамеренными и обычно – следствие недооценки врачами лекарственной патологии, то поражение печени, возникающее после приема психотропных средств или анальгетиков-антипиретиков, среди которых выделяется парацетамол, нередко является результатом их преднамеренного использования с суицидной целью на фоне депрессии как у взрослых, так и у подростков 12–17 лет.

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