Experience of using acitretin in genital form of scleroatrophic lichen with urethral lesion in men
https://doi.org/10.33667/2078-5631-2022-27-85-87
Abstract
The defeat of the genitals in scleroatrophic lichen is often accompanied by the involvement of the urethra in the process, which threatens serious complications and, first of all, the development of stricture. Therapy of such cases is difficult and ineffective in the case of topical corticosteroids. The article describes the positive experience of using acitretin at a dose of 25 mg per day for the treatment of scleroatrophic lichen, which occurs with damage to the external orifice and anterior segment of the urethra.
About the Author
A. V. Ignatovsky
Saint Petersburg State University
Russian Federation
Russian Federation
Ignatovsky Andrei V., PhD Med, associate professor at Dept of Infectious Diseases, Epidemiology and Dermatovenereology
Saint Petersburg
References
1. Stewart L, McCammon K, Metro M, Virasoro R (2014). SIU/ICUD consultation on urethral strictures: Anterior urethra-lichen sclerosus. Urology 83 (3 Suppl): S27–30.
2. Depasquale I, Park AJ, Bracka A. The treatment of balanitis xerotica obliterans. BJU Int. 2000; 86: 459–465.
3. Riddell L, Edwards A, Sherrard J. Clinical features of lichen sclerosus in men attending a department of genitourinary medicine. Sex Transm Infect. 2000; 76: 311–313 (Current treatment of lichen sclerosus and stricture Amanda S.J. Chung, Oscar A. Suarez).
4. Erickson BA, Elliott SP, Myers JB, Voelzke BB, Smith TG 3rd, McClung CD et al (2016). Understanding the relationship between chronic systemic disease and lichen sclerosus urethral strictures. J Urol 195 (2): 363–368.
5. Grimes MD, Tesdahl BA, Schubbe M, Dahmoush L, Pearlman AM, Kreder KJ et al (2019). Histopathology of anterior urethral strictures: towards a better understanding of stricture pathophysiology. J Urol. https://doi.org/10.1097/JU.0000000000000340.
6. Homer L., Buchanan, K.J., Nasr, B., Losty, P.D., & Corbett, H.J. (2014). Meatal stenosis in boys following circumcision for lichen sclerosus (balanitis xerotica obliterans). The journal of Urology, 192(6), 1784–1788.
7. Liu JS, Walker K, Stein D, Prabhu S, Hofer MD, Han J et al (2014). Lichen sclerosus and isolated bulbar urethral stricture disease. J Urol 192 (3): 775–779.
8. Clinical guidelines ‘Stricture of the urethra’ (approved by the Ministry of Health of the Russian Federation on June 4, 2021).
9. Bousema MT, Romppanen U, Geiger JM et al. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva: a double-blind, placebo-controlled study. J Am Acad Dermatol 1994; 30 (Pt 1): 225–231.
10. Niinimaki A, Kallioinen M, Oikarinen A. Etretinate reduces connective tissue degeneration in lichen sclerosus et atrophicus. Acta Derm Venereol 1989; 69: 439–442.
11. Ranum A., & Pearson D.R. (2021). Acitretin therapy for vulvar lichen sclerosus complicated by recurrent squamous cell carcinoma. JAAD Case Reports, 8, 53–55.
12. Ioannides D, Lazaridou E, Apalla Z et al. Acitretin for severe lichen sclerosus of male genitalia: a randomized, placebo-controlled study. J Urol 2010; 183: 1395–1399.
13. Kirtschig G., Cooper S., Aberer W., Günthert A., Becker K., Jasaitiene D., … & Wojnarowska F. (2017). Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus. Journal of the European Academy of Dermatology and Venereology: JEADV, 31 (2), e81–e83.
14. Potts BA, Belsante MJ, Peterson AC (2016) Intraurethral steroids are a safe an efective treatment for stricture disease in patients with biopsy proven lichen sclerosus. J Urol 195 (6): 1790–1796.
15. Bousema MT, Romppanen U, Geiger JM, et al. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva: a double-blind, placebo-controlled study. J Am Acad Dermatol. 1994; 30 (2): 225–231.
Review
For citations:
Ignatovsky A.V. Experience of using acitretin in genital form of scleroatrophic lichen with urethral lesion in men. Medical alphabet. 2022;1(27):85-87. (In Russ.) https://doi.org/10.33667/2078-5631-2022-27-85-87
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