Non-small cell lung cancer with activating EGFR-mutations: place of targeted therapy in immuno-oncology era
Abstract
The article discusses the place of targeted and immunotherapy in the treatment of advanced non-small-cell lung cancer with activating EGFR mutations. According to subgroup analyzes and meta-analysis of randomized clinical trials, inhibitors of immunity control points have no advantage over chemotherapy in this category of patients. One of the important factors explaining the relatively lower efficacy of anti-PD/PD-L1 monoclonal antibodies in EGFRm NSCLC is the low mutation load characteristic for tumors with driver mutations. On the contrary, targeted therapy with tyrosine kinase inhibitors in this population increases survival rate, provides a very high frequency of objective response and is characterized by rapid regression, which is very important in the symptomatic course of the disease and the high prevalence of the tumor process. Thus, tyrosine kinase inhibitors continue to be the standard for the therapy of patients with locally distributed or metastatic NSCLC EGFRm.
About the Author
E. V. Artamonova
Russian Oncological Scientific Centre n.a. N.N. Blokhin
Russian Federation
Russian Federation
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For citations:
Artamonova E.V. Non-small cell lung cancer with activating EGFR-mutations: place of targeted therapy in immuno-oncology era. Medical alphabet. 2017;2(25):17-26. (In Russ.)
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