T786C eNOS polymorphism as risk factor for recurrent myocardial infarction in young and middleaged patients
https://doi.org/10.33667/2078-5631-2020-28-17-21
Abstract
Objective. To determine the possible role of the endothelial nitric oxide synthase (eNOS) polymorphism T786C (rs 2070744) in developing of recurrent myocardial infarction (MI) in young and middle-aged patients. Materials and methods. 114 patients with acute MI treated with percutaneous coronary intervention and thrombolysis that were admitted to Clinical cardiologic dispensary (Perm city, Russia) were enrolled into a study. Among them there were 28 patients with recurrent MI. The eNOS T786C polymorphism were determined by real-time PCR. Results. In T786C polymorphism of eNOS, compared with the T/T genotype, it was determined that those with T/C has 2,27 fold (95 % CI: 1.01–5.49), and those with the CC genotype has 2.22 times (95 % CI: 1.30–8.53) (p = 0.034) greater risk of developing recurrent MI. Patients with severe coronary arteries atherosclerosis more frequently had eNOS T786C polymorphism of T/C genotype (OR = 4,67; 95 % CI: 1,38–15,37; p = 0,031). Conclusion. The eNOS T786C variants could be evaluated as recurrent MI risk factor in young and middle-aged patients.
About the Authors
E. A. Shishkina
Perm State Medical University n. a. E. A. Wagner
Russian Federation
Perm
Russian Federation
Perm
O. V. Khlynova
Perm State Medical University n. a. E. A. Wagner
Russian Federation
Perm
Russian Federation
Perm
A. V. Tuev
Perm State Medical University n. a. E. A. Wagner
Russian Federation
Perm
Russian Federation
Perm
A. V. Krivtsov
Federal Research Center for Medical and Preventive Technologies for Managing Public Health Risks
Russian Federation
Perm
Russian Federation
Perm
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Review
For citations:
Shishkina E.A., Khlynova O.V., Tuev A.V., Krivtsov A.V. T786C eNOS polymorphism as risk factor for recurrent myocardial infarction in young and middleaged patients. Medical alphabet. 2020;(28):17-21. (In Russ.) https://doi.org/10.33667/2078-5631-2020-28-17-21
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