Hypovitaminosis D effect on pericranial muscle dysfunction in women with chronic tension headache
https://doi.org/10.33667/2078-5631-2019-4-39(414)-24-27
Abstract
Background. Nowadays there are a large number of studies revealing the significance of hypovitaminosis D in chronic pain conditions and diseases, in which musculoskeletal factors are dominant in the formation of pain. In chronic tension type headache (CTTH) pathogenesis the role of muscular factor is well-established. However there is insufficient data regarding the interrelations between hypovitaminosis D, headache and pericraial muscle dysfunction (PMD) in CTTH.
Objective. To investigate the effect of vitamin D level on PMD and cephalgia parameters in CTTH.
Methods. One hundred twenty women with CTTH aged 25 to 55 years were enrolled. Evaluated parameters were the following: pericranial muscle tenderness (PMT), headache frequency (HF), headache duration (HD), headache intensity (HI). Vitamin D level measured by 25-hydroxyvitamin D [25(OH)D] of serum blood samples.
Results. Number of CTTH with DPM cases in the group of vitamin D deficiency (serum level of 25(OH)D less than 20 ng/mL) was equal to one in normal vitamin group (higher than 30 ng/mL), p > 0.05. Greater degree of DPM was identified in vitamin D deficiency than in normal level: total PMT score 5.0 vs 3.0 score (р < 0.001). At the same time significant difference was observed in cephalgia parameters between groups of deficiency and normal vitamin D level: HF 28.0 and 23.0 days per month (р < 0.001), HD 14.5 and 10.0 hours per day respectively. Also daily headache was associated with vitamin D deficiency with a risk ratio 4.4 (95 % CI: 1.4–14,0) as compared to the normal level. Middle-power negative correlation was noted between serum vitamin D levels and total PMT score (Spearman’s r = –0.55; р < 0,001), HF (r = –0.65; р < 0,001) and HD (r = 0.67; р < 0,001).
Conclusion. Vitamin D deficiency leads to increased degree of pericraial muscle dysfunction in CTTH women. That may result in rising central sensitization and finally be a reason of more severe headache.
About the Authors
A. A. Koloskova
I. M. Sechenov First Moscow State Medical University (Sechenov University); City Hospital No. 24 of the Avtozavodsky District of Nizhny Novgorod
Russian Federation
Moscow
Russian Federation
Moscow
O. V. Vorobieva
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Koloskova A.A., Vorobieva O.V. Hypovitaminosis D effect on pericranial muscle dysfunction in women with chronic tension headache. Medical alphabet. 2019;4(39):24-27. (In Russ.) https://doi.org/10.33667/2078-5631-2019-4-39(414)-24-27
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