Modern approaches to laboratory diagnostic of microspherocytic anemia

Abstract

Diagnosis of hereditary spherocytosis, as the most common form of membranopathy, is improved, thanks to advances in biotechnology and the presence of a large number of modern automatic analyzers. All this leads to a reduction in the number of patients with undiagnosed hereditary spherocytosis and a decrease in the incidence of complications. However, despite the improvement of various methods of evaluation of red blood cells, some difficulties in the diagnosis of hereditary spherocytosis remain. In this study, the authors developed an algorithm for the laboratory diagnosis of anemias microperimetry that will allow patients with high probability of hereditary spherocytosis differential diagnosis with other types of hemolytic anemia.