A rare form of acne fulminans. Management of a complex patient
https://doi.org/10.33667/2078-5631-2025-23-63-68
Abstract
The article presents the successful treatment of patient S. 15 years old with fulminant acne which may have developed due to an error in the simultaneous administration of doxycycline and isotretinoin. Despite a severe complication characterized by an island‑inflammatory reaction with the formation of nodules, pustules and erosive and ulcerative defects, stable remission was achieved. A key role in this was played by the strategy of consistent use of systemic glucocorticoids (prednisone), followed by gradual incorporation and titration of the dose of isotretinoin in the form of Lidose. The drug has demonstrated good tolerability and effectiveness even in a difficult clinical situation, making it possible to complete the full course of therapy with the achievement of the course dose. Lidose technology, which provides improved bioavailability regardless of food intake, is particularly valuable for patients whose lifestyle or gastrointestinal side effects make it difficult to comply with strict rules for taking standard isotretinoin. The article also discusses modern laser methods for correcting post‑acne residual phenomena.
Keywords
Supporting agencies: The work was done with the financial support of Jadran
About the Authors
M. B. Drozhdina
Kirov State Medical University
Russian Federation
Russian Federation
Drozhdina Marianna B., DM Sci (habil.), associate professor at Dept of Dermatovenereology and Cosmetology
Kirov
S. A. Smorodinova
Laser and Aesthetic Cosmetology Center (L’Code)
Russian Federation
Russian Federation
Smorodinova Svetlana A., cosmetologist, dermatovenereologist
Naberezhnye Chelny
V. A. Lazviashvili
Kirov State Medical University
Russian Federation
Russian Federation
Lazviashvili Varvara A., postgraduate student at Dept of Dermatovenereology
and Cosmetology
Kirov
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Review
For citations:
Drozhdina M.B., Smorodinova S.A., Lazviashvili V.A. A rare form of acne fulminans. Management of a complex patient. Medical alphabet. 2025;1(23):63-68. (In Russ.) https://doi.org/10.33667/2078-5631-2025-23-63-68
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