medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2019-1-1(376)-53-58medalphabet-935Research ArticleСтатьиРоль преконцепционной эндотелиальной дисфункции в развитии акушерских осложненийRole ofpreconception endothelial dysfunction in development of obstetric complicationsКузнецоваИ. В.KuznetsovaI. V.noemail@neicon.ruФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)» Минздрава РоссииРоссияFirst Moscow State Medical University n.a. I. M. SechenovRussian Federation20191001201911Современная гинекология5358Copyright © Кузнецова И.В., 20192019Кузнецова И.В.Kuznetsova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/935

В статье освещены патогенетические механизмы формирования эндотелиальной дисфункции и ее роль в возникновении гестационных осложнений. Рассмотрены основные задачи прегравидарной подготовки пациентов с заболеваниями, ассоциированными с эндотелиальной дисфункцией. Подчеркивается актуальность раннего выявления факторов риска гестационных осложнений, обусловленных дисфункцией эндотелия, и описываются методы ее косвенной оценки. Приведен перечень мероприятий, направленных на предотвращение клинической реализации эндотелиальной дисфункции, и описаны возможности ее терапевтической коррекции.

The article highlights the pathogenetic mechanisms of endothelial dysfunction formation and its role in the occurrence of gestational complications. The main tasks of the pregravid preparation of patients with diseases associated with endothelial dysfunction are considered. The relevance of early detection of risk factors for gestational complications caused by endothelial dysfunction is emphasized, and methods for its indirect assessment are described. A list of measures aimed at preventing the clinical implementation of endothelial dysfunction is given, and the possibilities of its therapeutic correction are described.

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The authors declare that there are no conflicts of interest present.