<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-864</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>НПВП-гастропатия в поликлинической практике</article-title><trans-title-group xml:lang="en"><trans-title>NSAID-gastropathyin polyclinical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осадчук</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osadchuk</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киреева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kireeva</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>A. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шорина</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shorina</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хударова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Hudarova</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>E. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University n.a. I. M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2018</year></pub-date><volume>3</volume><issue>30</issue><issue-title>Практическая гастроэнтерология</issue-title><fpage>33</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Осадчук М.А., Киреева Н.В., Лазарева А.Е., Шорина Д.А., Хударова А.А., Миронова Е.Д., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Осадчук М.А., Киреева Н.В., Лазарева А.Е., Шорина Д.А., Хударова А.А., Миронова Е.Д.</copyright-holder><copyright-holder xml:lang="en">Osadchuk M.A., Kireeva N.V., Lazareva A.E., Shorina D.A., Hudarova A.A., Mironova E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/864">https://www.med-alphabet.com/jour/article/view/864</self-uri><abstract><p>НПВП-гастропатия является одной из наиболее актуальных медицинских и социально-экономических проблем здравоохранения, стоящей на стыке многих терапевтических направлений. На сегодняшний день ацетилсалициловая кислота является одним из наиболее широко используемых лекарств в мире. По данным международных кардиологических и гастроэнтерологических ассоциаций, использование АСК в дозе 75 мг приводит к увеличению побочных эффектов со стороны желудочно-кишечного тракта в 2-4 раза. Данный факт обусловливает важность по ведению таких пациентов со стороны врачей - участковых терапевтов, а также профилактики НПВП-гастропатии среди населения в целом.</p></abstract><trans-abstract xml:lang="en"><p>NSAID-gastropathy is one of the most relevant medical and social problems of health care, which is at the crossroads of many therapeutic areas. Nowadays acetylsalicylic acid is one of the most widely used drugs in the world. According to the international cardiological and gastroenterological associations, the use of ASA in a dose of 75 mg leads to an increase in side effects from the gastrointestinal tract by 2-4 times. This fact determines the importance of the management of such patients by the doctors of the district physicians, as well as the prevention of NSAIDs-gastropathy in general.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>НПВП-гастропатия</kwd><kwd>профилактика</kwd><kwd>ацетилсалициловая кислота</kwd><kwd>ингибиторы протонной помпы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>NSAID-gastropathy</kwd><kwd>prophylaxis</kwd><kwd>acetylsalicylic acid</kwd><kwd>proton pump inhibitors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каратеев А. Е., Насонов Е. Л., Яхно Н. Н. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». // Современная ревматология. 2015; 9 (1): 4-23.</mixed-citation><mixed-citation xml:lang="en">Каратеев А. Е., Насонов Е. Л., Яхно Н. Н. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». // Современная ревматология. 2015; 9 (1): 4-23.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt D.L, Scheiman J., Abraham N.S. et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. // J Am Coll Cardiol. 2008; 52: 1502-1517.</mixed-citation><mixed-citation xml:lang="en">Bhatt D.L, Scheiman J., Abraham N.S. et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. // J Am Coll Cardiol. 2008; 52: 1502-1517.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">А. А. Свистунов, М. А. Осадчук, Н. В. Киреева, А. А. Хударова, Е. Е. Ачкасов НПВП-индуцированная энтеропатия: современное состояние проблемы. Тера певтический архив. 2018; 08: 95-100. doi. org/10.26442/terarkh201890895-100.</mixed-citation><mixed-citation xml:lang="en">А. А. Свистунов, М. А. Осадчук, Н. В. Киреева, А. А. Хударова, Е. Е. Ачкасов НПВП-индуцированная энтеропатия: современное состояние проблемы. Тера певтический архив. 2018; 08: 95-100. doi. org/10.26442/terarkh201890895-100.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Хударова А., Осадчук М. НПВП-гастропатии: прогнозирование течения и исходов // Врач.- 2018; 29 (5): 17-23. doi: 10.29296/25877305-2018-05-04.</mixed-citation><mixed-citation xml:lang="en">Хударова А., Осадчук М. НПВП-гастропатии: прогнозирование течения и исходов // Врач.- 2018; 29 (5): 17-23. doi: 10.29296/25877305-2018-05-04.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia Rodriguez L. A., Martin-Pérez M., Hennekens C. H., Rothwell P. M., Lanas A. Bleeding risk with long-term low-dose aspirin: a systematic review of observational studies. PLoS One. 2016; 11: e0160046.</mixed-citation><mixed-citation xml:lang="en">Garcia Rodriguez L. A., Martin-Pérez M., Hennekens C. H., Rothwell P. M., Lanas A. Bleeding risk with long-term low-dose aspirin: a systematic review of observational studies. PLoS One. 2016; 11: e0160046.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chi T. Y., Zhu H. M., Zhang M. Risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal bleeding resulting on people over 60 years old in Beijing. Medicine (Baltimore). 2018 May; 97 (18): e0665. doi: 10.1097/ MD.0000000000010665.</mixed-citation><mixed-citation xml:lang="en">Chi T. Y., Zhu H. M., Zhang M. Risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal bleeding resulting on people over 60 years old in Beijing. Medicine (Baltimore). 2018 May; 97 (18): e0665. doi: 10.1097/ MD.0000000000010665.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lanza F. L., Chan F. K., Quigley E. M. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. // Am J Gastroenterol. 2009; 104: 728-738.</mixed-citation><mixed-citation xml:lang="en">Lanza F. L., Chan F. K., Quigley E. M. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. // Am J Gastroenterol. 2009; 104: 728-738.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lavie C. J., Howden CW, Scheiman J, Tursi J. Upper Gastrointestinal Toxicity Associated With Long-Term Aspirin Therapy: Consequences and Prevention. // Curr Probl Cardiol. 2017 May; 42 (5): 146-164. doi: 10.1016/j.cpcardiol.2017.01.006. Epub 2017 Feb 1.</mixed-citation><mixed-citation xml:lang="en">Lavie C. J., Howden CW, Scheiman J, Tursi J. Upper Gastrointestinal Toxicity Associated With Long-Term Aspirin Therapy: Consequences and Prevention. // Curr Probl Cardiol. 2017 May; 42 (5): 146-164. doi: 10.1016/j.cpcardiol.2017.01.006. Epub 2017 Feb 1.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Malfertheiner P., Megraud F., O'Morain C. A. Gisbert J. P., Kuipers E. J., Axon A. T., Bazzoli F., Gasbarrini A., Atherton J., Graham D. Y., Hunt R., Moayyedi P., Rokkas T.1, Rugge M., Selgrad M., Suerbaum S., Sugano K., El-Omar E.M.20; Management of Helicobacter pylori infection - the Maastricht V/Florence Consensus Report Gut. 2017 Jan; 66 (1): 6-30. doi: 10.1136/ gutjnl-2016-312288. Epub 2016 Oct 5.</mixed-citation><mixed-citation xml:lang="en">Malfertheiner P., Megraud F., O'Morain C. A. Gisbert J. P., Kuipers E. J., Axon A. T., Bazzoli F., Gasbarrini A., Atherton J., Graham D. Y., Hunt R., Moayyedi P., Rokkas T.1, Rugge M., Selgrad M., Suerbaum S., Sugano K., El-Omar E.M.20; Management of Helicobacter pylori infection - the Maastricht V/Florence Consensus Report Gut. 2017 Jan; 66 (1): 6-30. doi: 10.1136/ gutjnl-2016-312288. Epub 2016 Oct 5.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Moore A., Makinson G., Li C. Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials. // Arthritis Res Ther 2013; 15 (1): 6.</mixed-citation><mixed-citation xml:lang="en">Moore A., Makinson G., Li C. Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials. // Arthritis Res Ther 2013; 15 (1): 6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Venerino M., Malfertheiner P. Interaction of Helicobacter pylori infection and Non-steroidal Anti-inflammatory Drugs in Gastric and Duodenal Ulcers // Helicobacter. 2010. Vol. 15. P. 239-250.</mixed-citation><mixed-citation xml:lang="en">Venerino M., Malfertheiner P. Interaction of Helicobacter pylori infection and Non-steroidal Anti-inflammatory Drugs in Gastric and Duodenal Ulcers // Helicobacter. 2010. Vol. 15. P. 239-250.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Szabó I. L., Matics R., Hegyi P., Garami A., Illés A., Sarlós P., Bajor J., Szucs A., Mosztbacher D., Marta K., Szemes K., Cseko K., Kovari B., Rumbus Z., Vincze A. PPIs Prevent Aspirin-Induced Gastrointestinal Bleeding Better than H2RAs. A Systematic Review and Meta-analysis. J Gastrointestin Liver Dis. 2017 Dec; 26 (4): 395-402. doi: 10.15403/ jgld.2014.1121.264.hra.</mixed-citation><mixed-citation xml:lang="en">Szabó I. L., Matics R., Hegyi P., Garami A., Illés A., Sarlós P., Bajor J., Szucs A., Mosztbacher D., Marta K., Szemes K., Cseko K., Kovari B., Rumbus Z., Vincze A. PPIs Prevent Aspirin-Induced Gastrointestinal Bleeding Better than H2RAs. A Systematic Review and Meta-analysis. J Gastrointestin Liver Dis. 2017 Dec; 26 (4): 395-402. doi: 10.15403/ jgld.2014.1121.264.hra.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
