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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-81</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Чувствительность к антибактериальным препаратам метициллинрезистентных стафилококков, выделенных от пациентов стационара скорой медицинской помощи</article-title><trans-title-group xml:lang="en"><trans-title>Antibiotic susceptibility of methicillin-resistant Staphylococcus spp., isolated from emergency hospital patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черненькая</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chyornenkaya</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евдокимова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Evdokimova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Research Institute of Emergency Care n.a. N.V. Sklifosovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2017</year></pub-date><volume>1</volume><issue>7</issue><issue-title>Эпидемиология и гигиена</issue-title><fpage>32</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черненькая Т.В., Евдокимова Н.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Черненькая Т.В., Евдокимова Н.В.</copyright-holder><copyright-holder xml:lang="en">Chyornenkaya T.V., Evdokimova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/81">https://www.med-alphabet.com/jour/article/view/81</self-uri><abstract><p>Во всем мире метициллинрезистентные стафилококки являются одними из наиболее частых патогенов в структуре возбудителей внутрибольничных инфекций. Изучена частота их выделения от пациентов стационара скорой медицинской помощи в 2016 году. Так, доля метициллинрезистентных штаммов среди S. aureus (MRSA) составила 63,4 %, а среди коагулазонегативных стафилококков (MRCNS) - 81,5 %. Все проанализированные штаммы были чувствительны к линезолиду. К ванкомицину были чувствительными 77,1 % MRSA и 100 % MRCNS, к даптомицину - 71,4 и 83,3 % соответственно, к цефтаролину - 37,1 % MRSA.</p></abstract><trans-abstract xml:lang="en"><p>Throughout the world, methicillin-resistant Staphylococcus spp. are the most commonly identified causative infective agents in patients of emergency hospitals. It has been studied the frequency of their detection in our emergency hospital in year 2016. Thus, the detection rate of methicillin-resistant Staphylococcus aureus (MRSA) was 63,4 % and coagulase-negative Staphylococcus spp. (MRCNS) was 81 %. All the strains were sensitive to linezolid. In addition, 71,1 % of MRSA and 100 % of MRCNS were sensitive to vancomycin; 71,4 % of MRSA and 83,3 % of MRCNS were sensitive to daptomycin; 37,1 % of MRSA were sensitive to ceftaroline.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>резистентность к антибиотикам</kwd><kwd>линезолид</kwd><kwd>ванкомицин</kwd><kwd>даптомицин</kwd><kwd>цефтаролин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Staphylococcus aureus</kwd><kwd>MRSA</kwd><kwd>MRCNS</kwd><kwd>Staphylococcus spp</kwd><kwd>Staphylococcus aureus</kwd><kwd>MRSA</kwd><kwd>MRCNS</kwd><kwd>resistance to antibiotics</kwd><kwd>linezolid</kwd><kwd>vancomycin</kwd><kwd>daptomycin</kwd><kwd>ceftaroline</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гостев В.В., Попенко Л.Н., Черненькая Т.В. [и др.] Оценка чувствительности MRSA к оксациллину, цефокситину, ванкомицину и даптомицину // Антибиотики и химиотерапия. - 2013. - Т. 58, № 9-10. - С. 13-20.</mixed-citation><mixed-citation xml:lang="en">Гостев В.В., Попенко Л.Н., Черненькая Т.В. [и др.] Оценка чувствительности MRSA к оксациллину, цефокситину, ванкомицину и даптомицину // Антибиотики и химиотерапия. - 2013. - Т. 58, № 9-10. - С. 13-20.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Козлова Н.С., Баранцевич Н.Е., Иванова Л.В. [и др.] Чувствительность к антибактериальным препаратам стафилококков, циркулирующих в многопрофильном стационаре // Проблемы медицинской микологии. - 2015. - Т. 17, № 4. - С. 58-62.</mixed-citation><mixed-citation xml:lang="en">Козлова Н.С., Баранцевич Н.Е., Иванова Л.В. [и др.] Чувствительность к антибактериальным препаратам стафилококков, циркулирующих в многопрофильном стационаре // Проблемы медицинской микологии. - 2015. - Т. 17, № 4. - С. 58-62.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Сухорукова М.В, Склеенова Е.Ю., Иванчик Н.В. [и др.] Антибиотикорезистентность нозокомиальных штаммов Staphylococcus aureus в стационарах России: результаты многоцентрового эпидемиологического исследования МАРАФОН в 2011-2012 гг. // Клиническая микробиология и антимикробная химиотерапия. - 2014. - Т. 16, № 4. - С. 280-286.</mixed-citation><mixed-citation xml:lang="en">Сухорукова М.В, Склеенова Е.Ю., Иванчик Н.В. [и др.] Антибиотикорезистентность нозокомиальных штаммов Staphylococcus aureus в стационарах России: результаты многоцентрового эпидемиологического исследования МАРАФОН в 2011-2012 гг. // Клиническая микробиология и антимикробная химиотерапия. - 2014. - Т. 16, № 4. - С. 280-286.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Antibiotics resistance ‘as big a risk as terrorism’ [Электронный ресурс]. - Режим доступа: // http://www.bbc.com/news/health-21737844.</mixed-citation><mixed-citation xml:lang="en">Antibiotics resistance ‘as big a risk as terrorism’ [Электронный ресурс]. - Режим доступа: // http://www.bbc.com/news/health-21737844.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Antimicrobial resistance surveillance in Europe 2014 [Электронный ресурс]. - Режим доступа: http://ecdc.europa.eu/en/publications/Report%20Assets/AER-AMR-2014/S%20aureus/number-saureus-isolates-and-percentage-resistant-meticilin-2011-2014.png.</mixed-citation><mixed-citation xml:lang="en">Antimicrobial resistance surveillance in Europe 2014 [Электронный ресурс]. - Режим доступа: http://ecdc.europa.eu/en/publications/Report%20Assets/AER-AMR-2014/S%20aureus/number-saureus-isolates-and-percentage-resistant-meticilin-2011-2014.png.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Coombs G.W., Daley D.A., Thin Lee Y. [et al.] Australian Group on Antimicrobial Resistance Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2014 // Commun. Dis. Intell. Q. Rep. - 2016. - Vol. 40, N. 2. - E244-254.</mixed-citation><mixed-citation xml:lang="en">Coombs G.W., Daley D.A., Thin Lee Y. [et al.] Australian Group on Antimicrobial Resistance Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2014 // Commun. Dis. Intell. Q. Rep. - 2016. - Vol. 40, N. 2. - E244-254.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dutton A.A., Elmes P.C. Vancomycin: report on treatment of patients with severe staphylococcal infections // Br. Med. J. - 1959 - Vol. 1. - P. 1144-5130.</mixed-citation><mixed-citation xml:lang="en">Dutton A.A., Elmes P.C. Vancomycin: report on treatment of patients with severe staphylococcal infections // Br. Med. J. - 1959 - Vol. 1. - P. 1144-5130.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">European Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters Version 6.0, valid from 2016-01-01 [Электронный ресурс].- Режим доступа: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6.0_Breakpoint_table.pdf.</mixed-citation><mixed-citation xml:lang="en">European Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters Version 6.0, valid from 2016-01-01 [Электронный ресурс].- Режим доступа: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6.0_Breakpoint_table.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Harrison E.M., Ba X., Blane B. [et al.] PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK // J. Antimicrob. Chemother. - 2016. - Vol. 71, N. 1. - P. 268-269.</mixed-citation><mixed-citation xml:lang="en">Harrison E.M., Ba X., Blane B. [et al.] PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK // J. Antimicrob. Chemother. - 2016. - Vol. 71, N. 1. - P. 268-269.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">van Hal S.J., Lodise T.P., Paterson D.L. The clinical significance of vancomycin minimum inhibitory concentration in Staphylococcus aureus infections: a systematic review and meta-analysis // Clin. Infect. Dis. - 2012. - Vol. 54, N. 6. - P. 755-771.</mixed-citation><mixed-citation xml:lang="en">van Hal S.J., Lodise T.P., Paterson D.L. The clinical significance of vancomycin minimum inhibitory concentration in Staphylococcus aureus infections: a systematic review and meta-analysis // Clin. Infect. Dis. - 2012. - Vol. 54, N. 6. - P. 755-771.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kelley W.L., Jousselin A., Barras Ch. [et al.] Missense Mutations in PBP2A Affecting ceftaroline susceptibility setected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus Clonotypes ST228 and ST247 in Western Switzerland archived since 1998 // Antimicrob. Agents Chemother. - 2015. - Vol. 59, N. 4. - P. 1922-1930.</mixed-citation><mixed-citation xml:lang="en">Kelley W.L., Jousselin A., Barras Ch. [et al.] Missense Mutations in PBP2A Affecting ceftaroline susceptibility setected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus Clonotypes ST228 and ST247 in Western Switzerland archived since 1998 // Antimicrob. Agents Chemother. - 2015. - Vol. 59, N. 4. - P. 1922-1930.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Antimicrobial resistance: global report on surveillance 2014 [Электронный ресурс] // Geneva, Switzerland: WHO, 2014. - Режим доступа: http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf?ua=1.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Antimicrobial resistance: global report on surveillance 2014 [Электронный ресурс] // Geneva, Switzerland: WHO, 2014. - Режим доступа: http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf?ua=1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
