medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-792Research ArticleСтатьиПрофилактика и терапия гестационных осложнений, связанных с эндотелиальной дисфункциейProphylaxis and therapy of gestational complications associated with endothelial dysfunctionКузнецоваИ. В.KuznetsovaI. V.noemail@neicon.ruФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава РоссииРоссияFirst Moscow State Medical University n.a. I.M. SechenovRussian Federation201818072018322Современная гинекология2323Copyright © Кузнецова И.В., 20182018Кузнецова И.В.Kuznetsova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/792

Одной из главных причин привычного невынашивания беременности, преэклампсии, синдрома задержки развития плода, гипертензивных осложнений беременности является нарушение микроциркуляции и повышение внутрисосудистого свертывания крови. В свою очередь, микроциркуляторные нарушения становятся результатом действия нескольких патогенетических механизмов, среди которых большое значение заслуженно придается эндотелиальной дисфункции. В обзоре обсуждаются физиологические аспекты повышения свертывания крови во время беременности и вопросы патогенеза осложнений гестации с позиций нарушений функции эндотелия и повышения свертываемости крови. Освещаются заболевания и состояния, риск которых связан с эндотелиальной дисфункцией. Рассматриваются методы фармакотерапии, направленные на профилактику и лечение гестационных осложнений. Особое внимание уделяется лекарственному средству сулодексид - антикоагулянту, представителю семейства гликозаминогликанов, обладающему уникальным профилем преимущественного положительного влияния на функции эндотелия.

One of the main causes of habitual miscarriage, preeclampsia, fetal development retardation, hypertensive complications of pregnancy is a violation of microcirculation and increased intravascular coagulation. In turn, microcirculatory disorders are the result of several pathogenetic mechanisms, among which great importance is given to endothelial dysfunction. The review discusses the physiological aspects of increasing blood coagulation during pregnancy and questions of the pathogenesis of complications of gestation from the standpoint of endothelial dysfunction and increased coagulability of the blood. Illuminates diseases and conditions, the risk of which is associated with endothelial dysfunction. Methods of pharmacotherapy aimed at the prevention and treatment of gestational complications are considered. Particular attention is paid to the drug sulodexide - anticoagulant, a representative of the glycosaminoglycan family, which has a unique profile of a predominantly positive effect on endothelial function.

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The authors declare that there are no conflicts of interest present.