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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Неоадъювантная лучевая терапия, неоадъювантная химиотерапия и радикальная мастэктомия у больной раком молочной железы с одномоментным выполнением реконструктивно-пластической операции: собственный опыт</article-title><trans-title-group xml:lang="en"><trans-title>Neoadjuvant radiotherapy, neoadjuvant chemotherapy and mastectomy with immediate breast reconstruction in breast cancer patient: own experience</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачев</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachyov</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назаренко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarenko</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимошкина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Timoshkina</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимова</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimova</surname><given-names>O. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глебовская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glebovskaya</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>1Vanov</surname><given-names>S. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисова</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisova</surname><given-names>T. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre of Oncology n.a. N. N. Blokhin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>19</day><month>09</month><year>2018</year></pub-date><volume>2</volume><issue>29</issue><issue-title>Диагностика и онкотерапия</issue-title><fpage>44</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ткачев С.И., Назаренко А.В., Тимошкина Е.В., Трофимова О.П., Глебовская В.В., Иванов С.М., Борисова Т.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Ткачев С.И., Назаренко А.В., Тимошкина Е.В., Трофимова О.П., Глебовская В.В., Иванов С.М., Борисова Т.Н.</copyright-holder><copyright-holder xml:lang="en">Tkachyov S.I., Nazarenko A.V., Timoshkina E.V., Trofimova O.P., Glebovskaya V.V., 1Vanov S.M., Borisova T.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/761">https://www.med-alphabet.com/jour/article/view/761</self-uri><abstract><p>Современное комбинированное лечение больных раком молочной железы все чаще включает в себя проведение реконструктивно-пластической операции на молочной железе, так как данный подход улучшает качество жизни пациенток. Однако по-прежнему выполнение такого оперативного вмешательства может привести к значительному количеству осложнений. Одним из вариантов, позволяющих уменьшить частоту осложнений с сохранением общей и безрецидивной выживаемости, является проведение химиотерапии и лучевой терапии в неоадъювантном режиме. В статье представлен клинический случай местнораспространенного рака молочной железы, по поводу которого были последовательно проведены химиотерапия, лучевая терапия и далее радикальная мастэктомия с одномоментной реконструктивно-пластической операцией.</p></abstract><trans-abstract xml:lang="en"><p>Contemporary combined therapy in breast cancer patients includes breast reconstruction more and more often nowadays because this approach improves patients’ quality of life. But still reconstructive surgery may lead to significant amount of complications. One of the approaches which can decrease complication rate while keeping overall survival and relapse-free survival the same is neoadjuvant chemotherapy and neoadjuvant radiotherapy. In this article is presented a case of advanced breast cancer which was treated consequentially with chemotherapy, radiotherapy and mastectomy with immediate breast reconstruction.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>неоадъювантная лучевая терапия</kwd><kwd>реконструктивно-пластическая операция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>neoadjuvant radiotherapy</kwd><kwd>breast reconstruction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2016 году (заболеваемость и смертность). Под редакцией А. Д. Каприна, В. В. Старинского, Г. В. Петровой. 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