medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-675Research ArticleСтатьиКофеин и его влияние на нейродегенеративные заболеванияCaffeine and neurodegenerative disordersСеливерстовЮ. А.SelivyorstovYu. A.noemail@neicon.ruБабинМ. Е.BabinM. E.noemail@neicon.ruФГБНУ «Научный центр неврологии»РоссияScientific Centre of NeurologyRussian FederationФГБОУ ВО «Московский государственный университет имени М. В. Ломоносова»РоссияMoscow State University n.a. M. V. LomonosovRussian Federation201803062018217Неврология и психиатрия3742Copyright © Селиверстов Ю.А., Бабин М.Е., 20182018Селиверстов Ю.А., Бабин М.Е.Selivyorstov Y.A., Babin M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/675

Увеличение распространенности нейродегенеративных заболеваний обусловливает необходимость всестороннего поиска возможных факторов, влияющих на их течение. Кофеин является одним из наиболее широко употребляемых психоактивных веществ в мире. Его действие является дозозависимым и реализуется с участием нескольких механизмов, основной из которых - неселективное блокирование аденозиновых рецепторов. В настоящем обзоре представлена краткая информация о кофеине и его влиянии на такие нейродегенеративные заболевания, как болезнь Паркинсона, болезнь Альцгеймера, болезнь Гентингтона и боковой амиотрофический склероз.

Prevalence of the neurodegenerative disorders is progressively increasing. This demands search for the approaches to modifying their progression. Caffeine is one of the most widely consumed psychoactive substances globally. Its effects are dose-dependent, and among caffeine’s mechanisms of action the main one is non-specific antagonism to adenosine receptors. In this review, current knowledge on use of caffeine in such neurodegenerative disorders as Parkinson’s disease, Alzheimer’s disease, Huntington's disease, and amyotrophic lateral sclerosis is summarized.

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The authors declare that there are no conflicts of interest present.