medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-536Research ArticleСтатьиКлиническая значимость и возможности лабораторной диагностики Corynebacterium urealyticumClinical importance and possibilities of laboratory diagnostics of Corynebacterium urealyticumЕвдокимоваН. В.EvdokimovaN. V.noemail@neicon.ruЧерненькаТ. В.ChernenkayaT. V.noemail@neicon.ruГБУЗ «Научно-исследовательский институт скорой помощи имени Н. В. Склифосовского» Департамента здравоохранения г. МосквыРоссияResearch Institute of Emergency Care n.a. N. V. SklifosovskyRussian Federation20181502201815Современная лаборатория1719Copyright © Евдокимова Н.В., Черненька Т.В., 20182018Евдокимова Н.В., Черненька Т.В.Evdokimova N.V., Chernenkaya T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/536

В обзоре рассмотрены результаты изучения возбудителя госпитальных инфекций Corynebacterium urealyticum с точки зрения его лабораторной диагностики и способности вызывать воспалительные заболевания, такие как цистит, пиелонефрит, бактериемия и сепсис. В ходе рутинной лабораторной практики Corynebacterium urealyticum, как правило, не выделяют, традиционно считая их, как и большинство других видов коринебактерий, контаминантами, а также из-за медленного роста, видимого не ранее чем через 48 часов. Фенотипическую идентификацию Corynebacterium urealyticum проводят, используя API Coryne и тест на уреазу, с помощью молекулярно-биологических методов (RT-PCR с праймерами для микобактерий). В настоящее время для идентификации также применяют MALDI-TOF MS. Согласно имеющимся данным, большая часть штаммов C. urealyticum резистентны к бета-лактамным антибиотикам, аминогликозидам и тетрациклинам.

In this review it has been regarded a nosocomial pathogen Corynebacterium urealyticum with respect to its laboratory investigation, relationship to diseases including cystitis, pyelonephritis, bacteremia and sepsis. It is usually missed in routine culture because of its coryneform morphology (considered as contaminant), and it requires 48 hours of incubation to grow. It can be diagnosed using phenotypic (API Coryne, urease test) and molecular methods (RT-PCR using mycobacterial primers). Recently MALDI-TOF MS has also been used for its identification. According to the information available in the literature, C. urealyticum isolates are resistent to fi-lactams, aminoglycosides, and tetracycline.

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The authors declare that there are no conflicts of interest present.