<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-520</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение резистентной артериальной гипертонии</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and treatment of resistant hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гринштейн</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Grinshtein</surname><given-names>Yu. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабалин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabalin</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В. Ф. Войно-Ясенецкого» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University n.a. prof. V. F. Voino-Yasenetsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2018</year></pub-date><volume>1</volume><issue>3</issue><issue-title>Артериальная гипертензия</issue-title><fpage>37</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гринштейн Ю.И., Шабалин В.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Гринштейн Ю.И., Шабалин В.В.</copyright-holder><copyright-holder xml:lang="en">Grinshtein Y.I., Shabalin V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/520">https://www.med-alphabet.com/jour/article/view/520</self-uri><abstract><p>Резистентная гипертония (РГ) представляет собой артериальную гипертонию, не контролируемую на комбинации оптимальных доз трех гипотензивных препаратов, одним из которых является диуретик, при условии изменения образа жизни. В обзорной статье обсуждаются современные подходы к классификации РГ, алгоритму диагностики, дифференциальной диагностики и лечению. Особое внимание уделяется необходимости суточного мониторирования артериального давления для выделения специфических форм РГ и псевдорезистентности. Представлены традиционные и новые подходы к оптимальной медикаментозной и интервенционной терапии. Подробно освещены спорные моменты применения новых интервенционных методик коррекции РГ в реальной клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Resistant hypertension (RH) can be defined as arterial hypertension not controlled by the use of three antihypertensive medicines (one being a diuretic) at optimal doses provided changed lifestyle. The present review summarizes the modern approaches to RH classification, diagnostic algorithm, differential diagnoses, and treatment. Special attention is paid to ambulatory blood pressure monitoring as essential tool for distinguishing specific hypertension types and pseudoresistance verification. Both traditional and new options of medicinal and interventional therapies are presented. Controversial issues of interventional techniques for RH correction are also discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>резистентная гипертония</kwd><kwd>диагностика</kwd><kwd>фармакотерапия</kwd><kwd>ренальная денервация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>resistant hypertension</kwd><kwd>diagnosis</kwd><kwd>pharmacotherapy</kwd><kwd>renal denervation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">de Oliveira C., Marmot M. G., Demakakos P., de Melo Mambrini J. V., Peixoto S. V., Viana S., Lima-Costa M.F. Mortality risk attributable to smoking, hypertension and diabetes among English and Brazilian older adults (The ELSA and Bambui cohort ageing studies) // Eur J Public Health.-2015.-Dec,14.-pii: ckv225.</mixed-citation><mixed-citation xml:lang="en">de Oliveira C., Marmot M. G., Demakakos P., de Melo Mambrini J. V., Peixoto S. V., Viana S., Lima-Costa M.F. Mortality risk attributable to smoking, hypertension and diabetes among English and Brazilian older adults (The ELSA and Bambui cohort ageing studies) // Eur J Public Health.-2015.-Dec,14.-pii: ckv225.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">European Guidelines On Cardiovascular Disease Prevention In Clinical Practice // Eur Hear J.-2016.- 37.- P. 2315-2381.</mixed-citation><mixed-citation xml:lang="en">European Guidelines On Cardiovascular Disease Prevention In Clinical Practice // Eur Hear J.-2016.- 37.- P. 2315-2381.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гринштейн Ю. И., Петрова М. М., Шабалин В. В. и др. Распространенность артериальной гипертонии в Красноярском крае по данным эпидемиологического исследования ЭССЕ-РФ// Артериальная гипертензия.- 2016.- Том 22, № 6.- С. 551-559.</mixed-citation><mixed-citation xml:lang="en">Гринштейн Ю. И., Петрова М. М., Шабалин В. В. и др. Распространенность артериальной гипертонии в Красноярском крае по данным эпидемиологического исследования ЭССЕ-РФ// Артериальная гипертензия.- 2016.- Том 22, № 6.- С. 551-559.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Artyukhov I. P., Grinshtein Yu.I., Petrova M. M., Shabalin V. V., Ruf R. R. Prevalence of arterial hypertension in the Krasnoyarsk Krai (Siberia, Russia) // BMS Cardiovascular Disorders.-2017: 138 DOI 10.1186/ s12872-017-0559-5.</mixed-citation><mixed-citation xml:lang="en">Artyukhov I. P., Grinshtein Yu.I., Petrova M. M., Shabalin V. V., Ruf R. R. Prevalence of arterial hypertension in the Krasnoyarsk Krai (Siberia, Russia) // BMS Cardiovascular Disorders.-2017: 138 DOI 10.1186/ s12872-017-0559-5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sim J. J., Bhandari S. K., Shi J. et al. Characteristics of resistant hypertension in a large, ethnically diverse hypertension population of an integrated health system // Mayo Clin. Proc.-2013.- Vol. 88, № 10.-Р. 1099-1107.</mixed-citation><mixed-citation xml:lang="en">Sim J. J., Bhandari S. K., Shi J. et al. Characteristics of resistant hypertension in a large, ethnically diverse hypertension population of an integrated health system // Mayo Clin. Proc.-2013.- Vol. 88, № 10.-Р. 1099-1107.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dudenbostel T. Resistant hypertension - complex mix of secondary causes and comorbidities // J. Hum. Hypertens. - 2014.- Vol. 28, № 1.- P. 1-2.</mixed-citation><mixed-citation xml:lang="en">Dudenbostel T. Resistant hypertension - complex mix of secondary causes and comorbidities // J. Hum. Hypertens. - 2014.- Vol. 28, № 1.- P. 1-2.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Muxfeldt E.S., de Souza F., Margallo V.S. et al. Cardiovascular and renal complications in patients with resistant hypertension // Curr. Hypertens. Rep. - 2014.- Vol. 16, № 9.- P. 471.</mixed-citation><mixed-citation xml:lang="en">Muxfeldt E.S., de Souza F., Margallo V.S. et al. Cardiovascular and renal complications in patients with resistant hypertension // Curr. Hypertens. Rep. - 2014.- Vol. 16, № 9.- P. 471.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">de la Sierra A., Segura J., Banegas J. R. et al. Clinical features of8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring // Hypertension.- 2011.- Vol. 57, № 5. - Р. 898-902.</mixed-citation><mixed-citation xml:lang="en">de la Sierra A., Segura J., Banegas J. R. et al. Clinical features of8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring // Hypertension.- 2011.- Vol. 57, № 5. - Р. 898-902.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kleman M., Dhaniamraji S., Difillippo W. Prevalance and characteristics of pseudohypertension in patients with “resistant Hypertension” // J. Am. Soc. Hypertens.- 2013.- Vol. 7, № 6.- Р. 467-470.</mixed-citation><mixed-citation xml:lang="en">Kleman M., Dhaniamraji S., Difillippo W. Prevalance and characteristics of pseudohypertension in patients with “resistant Hypertension” // J. Am. Soc. Hypertens.- 2013.- Vol. 7, № 6.- Р. 467-470.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Weber F., Anlauf M. Treatment resistant hypertension - investiagation and conservative management // Dtsch. Arztebl. Int. - 2014.- Vol. 111, № 25.- Р. 425-431.</mixed-citation><mixed-citation xml:lang="en">Weber F., Anlauf M. Treatment resistant hypertension - investiagation and conservative management // Dtsch. Arztebl. Int. - 2014.- Vol. 111, № 25.- Р. 425-431.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Denolle T., Azizi M., Massart C. et al. Itraconazole: a new drug-related cause of hypertension // Ann. Cardiol. Angeiol. (Paris).- 2014.- Vol. 63, № 3.- Р. 213-215.</mixed-citation><mixed-citation xml:lang="en">Denolle T., Azizi M., Massart C. et al. Itraconazole: a new drug-related cause of hypertension // Ann. Cardiol. Angeiol. (Paris).- 2014.- Vol. 63, № 3.- Р. 213-215.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Judd E., Calhone D.A. Apparent and true resistant hypertension: definition, prevalence and outcomes // J. Hum. Hyper-tens.- 2014.- Vol. 28, № 8.- Р. 463-468.</mixed-citation><mixed-citation xml:lang="en">Judd E., Calhone D.A. Apparent and true resistant hypertension: definition, prevalence and outcomes // J. Hum. Hyper-tens.- 2014.- Vol. 28, № 8.- Р. 463-468.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dudenbostel T. Resistant hypertension - complex mix of secondary causes and comorbidities // J. Hum. Hypertens.-2014.- Vol. 28, № 1.- P. 1-2.</mixed-citation><mixed-citation xml:lang="en">Dudenbostel T. Resistant hypertension - complex mix of secondary causes and comorbidities // J. Hum. Hypertens.-2014.- Vol. 28, № 1.- P. 1-2.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Muxfeldt E. S., Margallo V.S., Guimaraes G. M. Prevalence and associated factors of obstructive sleep apnea in patients with resistant hypertension // Am. J. Hyper-tens. - 2014.- Vol. 27, № 8. - Р. 1069-1078.</mixed-citation><mixed-citation xml:lang="en">Muxfeldt E. S., Margallo V.S., Guimaraes G. M. Prevalence and associated factors of obstructive sleep apnea in patients with resistant hypertension // Am. J. Hyper-tens. - 2014.- Vol. 27, № 8. - Р. 1069-1078.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Daugherty S. L., Powers J. D., Magid D.J. et al. Incidence and prognosis of resistant hypertension in hypertensive patients // Circulation.- 2012.- Vol. 125, № 13.- Р. 1635-1642.</mixed-citation><mixed-citation xml:lang="en">Daugherty S. L., Powers J. D., Magid D.J. et al. Incidence and prognosis of resistant hypertension in hypertensive patients // Circulation.- 2012.- Vol. 125, № 13.- Р. 1635-1642.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G., Fagard R., Narkieicz K. et al. 2013 practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of cardiology (ESC): e-mail: medalfavit@mail.ru Медицинский алфавит № 3 / 2018, том № 1 Артериальная гипертензия 2013.- Vol. 31, № 10.- Р. 1925-1938.</mixed-citation><mixed-citation xml:lang="en">Mancia G., Fagard R., Narkieicz K. et al. 2013 practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of cardiology (ESC): e-mail: medalfavit@mail.ru Медицинский алфавит № 3 / 2018, том № 1 Артериальная гипертензия 2013.- Vol. 31, № 10.- Р. 1925-1938.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Okawa T., Obara T., Ohkubo T. et al. Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measure -ments: the J-HOME study // J. Hypertens.- 2006.- Vol. 24, № 9.- Р. 1737-1743.</mixed-citation><mixed-citation xml:lang="en">Okawa T., Obara T., Ohkubo T. et al. Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measure -ments: the J-HOME study // J. Hypertens.- 2006.- Vol. 24, № 9.- Р. 1737-1743.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Guichard J. L., Clark D. 3rd, Calhoun D. A. et al. Aldosterone receptor antagonists: current perspectives and therapies / / Vasc Health Risk Manag.-2013.- 9.- P. 321-31.</mixed-citation><mixed-citation xml:lang="en">Guichard J. L., Clark D. 3rd, Calhoun D. A. et al. Aldosterone receptor antagonists: current perspectives and therapies / / Vasc Health Risk Manag.-2013.- 9.- P. 321-31.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bobrie G., Frank M., Azizi M. et al. Sequential nephron blockade versus sequential renin-angiotensin system blockade in resistanthypertension: a prospective, randomized, open blinded endpoint study // J Hypertens. - 2012. - 30, № 8.- P. 1656-64.</mixed-citation><mixed-citation xml:lang="en">Bobrie G., Frank M., Azizi M. et al. Sequential nephron blockade versus sequential renin-angiotensin system blockade in resistanthypertension: a prospective, randomized, open blinded endpoint study // J Hypertens. - 2012. - 30, № 8.- P. 1656-64.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Beaussier H., Boutouyrie, Bobrie G. et al. True antihypertensive efficacy of sequential nephron blockade in patients with resistanthypertension and confirmed medication adherence // J Hypertens.- 2015.- 33, № 12.- P. 2526-33.</mixed-citation><mixed-citation xml:lang="en">Beaussier H., Boutouyrie, Bobrie G. et al. True antihypertensive efficacy of sequential nephron blockade in patients with resistanthypertension and confirmed medication adherence // J Hypertens.- 2015.- 33, № 12.- P. 2526-33.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Krum H., Schlaich M., Whitbourn R. et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study // Lancet 2009. - 373 (9671).- P. 1275-81.</mixed-citation><mixed-citation xml:lang="en">Krum H., Schlaich M., Whitbourn R. et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study // Lancet 2009. - 373 (9671).- P. 1275-81.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Krum H., Schlaich M. P., Sobotka PA. et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study // Lancet 2014.- 383 (9917).- P. 622-29.</mixed-citation><mixed-citation xml:lang="en">Krum H., Schlaich M. P., Sobotka PA. et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study // Lancet 2014.- 383 (9917).- P. 622-29.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Symplicity HTN-2 Investigators, Esler M. D., Krum H., Sobotka P. A. et al. Renal sympathetic denervation in patients with treat ment-resistanthypertension (The Symplicity HTN-2 Trial): a randomized controlled trial //Lancet 2010.-376 (9756).-P. 1903-09.</mixed-citation><mixed-citation xml:lang="en">Symplicity HTN-2 Investigators, Esler M. D., Krum H., Sobotka P. A. et al. Renal sympathetic denervation in patients with treat ment-resistanthypertension (The Symplicity HTN-2 Trial): a randomized controlled trial //Lancet 2010.-376 (9756).-P. 1903-09.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Esler M.D, Bohm M., Sievert H. et al. Catheter-based renal denervation for the treatment of patients for the treatment of patients with treatment-resistant hypertension: 36 month results from the SIMPLICITY HTN-2 randomized clinical trial // Eur Heart J 2014. - 35 (26).- P. 1752-59.</mixed-citation><mixed-citation xml:lang="en">Esler M.D, Bohm M., Sievert H. et al. Catheter-based renal denervation for the treatment of patients for the treatment of patients with treatment-resistant hypertension: 36 month results from the SIMPLICITY HTN-2 randomized clinical trial // Eur Heart J 2014. - 35 (26).- P. 1752-59.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Davis M. I., Filion K. B., Zhang D. et al. Effectiveness of renal denervation therapy for resistant hypertension: a systematic review and meta-analysis // J Am Coll Cardiol 2013.- 62 (3).- P. 231-41.</mixed-citation><mixed-citation xml:lang="en">Davis M. I., Filion K. B., Zhang D. et al. Effectiveness of renal denervation therapy for resistant hypertension: a systematic review and meta-analysis // J Am Coll Cardiol 2013.- 62 (3).- P. 231-41.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mahfoud F., Luscher T. F., Andersson B. et al. Expert consensus document from the European Society of Cardiology on catheter-based renal denervation // Eur Heart J 2013.- 34 (28).- P. 2149-57.</mixed-citation><mixed-citation xml:lang="en">Mahfoud F., Luscher T. F., Andersson B. et al. Expert consensus document from the European Society of Cardiology on catheter-based renal denervation // Eur Heart J 2013.- 34 (28).- P. 2149-57.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Schlaich M. P., Schmieder R.E., Bakris G. et al. International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension // J Am Coll Cardiol 2013.- 62 (22).- P. 2031-45.</mixed-citation><mixed-citation xml:lang="en">Schlaich M. P., Schmieder R.E., Bakris G. et al. International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension // J Am Coll Cardiol 2013.- 62 (22).- P. 2031-45.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tsioufis C., Mahfould F., Mancia G. et al. What the interventionalist should know about renal denervation in hypertensive patients: a position paper by the ESH WG on the interventional treatment of hypertension // Eurointervention 2014.- 9 (9).- P. 1027-35.</mixed-citation><mixed-citation xml:lang="en">Tsioufis C., Mahfould F., Mancia G. et al. What the interventionalist should know about renal denervation in hypertensive patients: a position paper by the ESH WG on the interventional treatment of hypertension // Eurointervention 2014.- 9 (9).- P. 1027-35.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hering D., Esler M. D., Schlaich M. P. et al. Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation// EuroIntervention 2013.- 9 Suppl.- P. 127-35.</mixed-citation><mixed-citation xml:lang="en">Hering D., Esler M. D., Schlaich M. P. et al. Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation// EuroIntervention 2013.- 9 Suppl.- P. 127-35.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler A. K., Franke J., Bertog S. C. Renal denervation in a patient with prior renal artery stenting // Catheter Cardiovasc inter/2013.- 81 (2).- P. 342-45.</mixed-citation><mixed-citation xml:lang="en">Ziegler A. K., Franke J., Bertog S. C. Renal denervation in a patient with prior renal artery stenting // Catheter Cardiovasc inter/2013.- 81 (2).- P. 342-45.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt D. L., Kandzari D. E., O’Neill W.W. et al. A controlled trial of renal denervation for resistant hypertension // N Engl J Med 2014.- 370 (15).- P. 1393-401.</mixed-citation><mixed-citation xml:lang="en">Bhatt D. L., Kandzari D. E., O’Neill W.W. et al. A controlled trial of renal denervation for resistant hypertension // N Engl J Med 2014.- 370 (15).- P. 1393-401.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Schlaich M. P., Esler M. D., Fink G. D. et al. Targeting the sympathetic nervous system: critical issues in patient selection, efficacy, and safety of renal denervation // Hypertension 2014.- 63 (3).- P. 426-32.</mixed-citation><mixed-citation xml:lang="en">Schlaich M. P., Esler M. D., Fink G. D. et al. Targeting the sympathetic nervous system: critical issues in patient selection, efficacy, and safety of renal denervation // Hypertension 2014.- 63 (3).- P. 426-32.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pathak A., Ewen S., Fajadet J. et al. From Symlicity HTN-3 to the Renal Denervation Global Registry: where do we stand and where should we go? // EuroIntervention 2014.- 10 (1).-21-3.</mixed-citation><mixed-citation xml:lang="en">Pathak A., Ewen S., Fajadet J. et al. From Symlicity HTN-3 to the Renal Denervation Global Registry: where do we stand and where should we go? // EuroIntervention 2014.- 10 (1).-21-3.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bohm M., Mahfoud F., Ukena C. et al. Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry // Euro Intervention 2013.- 9 (4). - P. 484-92.</mixed-citation><mixed-citation xml:lang="en">Bohm M., Mahfoud F., Ukena C. et al. Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry // Euro Intervention 2013.- 9 (4). - P. 484-92.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ariyanon W., Mao H., Adybelli 1. et al. Renal denervation: intractable hypertension and beyond // CardioRenalMed2014.-4 (1).-P. 22-3.</mixed-citation><mixed-citation xml:lang="en">Ariyanon W., Mao H., Adybelli 1. et al. Renal denervation: intractable hypertension and beyond // CardioRenalMed2014.-4 (1).-P. 22-3.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mendelsohn F. O. Does complete renal denervation translate into superior clinical outcomes? Lessons learned from denervation of accessory renal arteries // Clin Res Cardiol2014.- 103 (9).- P. 681-3.</mixed-citation><mixed-citation xml:lang="en">Mendelsohn F. O. Does complete renal denervation translate into superior clinical outcomes? Lessons learned from denervation of accessory renal arteries // Clin Res Cardiol2014.- 103 (9).- P. 681-3.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ott C., Mahfoud F., Schmid A. et al. Improvement of albuminuria after renal denervation // Int J Cardiol2014.- 173 (2).-P. 311-5.</mixed-citation><mixed-citation xml:lang="en">Ott C., Mahfoud F., Schmid A. et al. Improvement of albuminuria after renal denervation // Int J Cardiol2014.- 173 (2).-P. 311-5.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mahfoud F., Urban D., Teller D. et al. Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial // Eur Heart J 2014. - 35 (33). - 2224-31.</mixed-citation><mixed-citation xml:lang="en">Mahfoud F., Urban D., Teller D. et al. Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial // Eur Heart J 2014. - 35 (33). - 2224-31.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
