<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-515</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Изучение гендерных особенностей эффективности антигипертензивной терапии тройной фиксированной комбинацией</article-title><trans-title-group xml:lang="en"><trans-title>The study of gender-specific efficacy of triple fixed combination of antihypertensive therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чукаева</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chukaeva</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Спирякина</surname><given-names>Я. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Spiryakina</surname><given-names>Ya. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlov</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глибко</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glibko</surname><given-names>K. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University n.a. N. I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Городская клиническая больница № 13» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital № 13</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2018</year></pub-date><volume>1</volume><issue>3</issue><issue-title>Артериальная гипертензия</issue-title><fpage>16</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чукаева И.И., Орлова Н.В., Спирякина Я.Г., Орлов Д.А., Глибко К.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Чукаева И.И., Орлова Н.В., Спирякина Я.Г., Орлов Д.А., Глибко К.В.</copyright-holder><copyright-holder xml:lang="en">Chukaeva I.I., Orlova N.V., Spiryakina Y.G., Orlov D.A., Glibko K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/515">https://www.med-alphabet.com/jour/article/view/515</self-uri><abstract><p>Индивидуальный подбор гипотензивной терапии возможен с учетом гендерных особенностей пациентов. В статье рассматривается применение тройной фиксированной комбинации антигипертензивных препаратов амлодипина/индапамида/периндоприла в индивидуально подобранной дозировке у пациентов с артериальной гипертензией высокого и очень высокого риска. Приведен анализ эффективности используемой фиксированной комбинации в зависимости от пола пациентов.</p></abstract><trans-abstract xml:lang="en"><p>Individual choice of antihypertensive therapy depends on gender characteristics of patients. The article discusses the use of triple fixed combination of antihypertensive drugs amlodipine/ indapamide/perindopril in individually selected doses in hypertensive patients of high and very high risk. The effectiveness of the fixed combination, depending on the gender of the patients, was analyzed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>гендерные различия</kwd><kwd>тройная фиксированная комбинация</kwd><kwd>амлодипин</kwd><kwd>индапамид</kwd><kwd>периндоприл</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>gender differences</kwd><kwd>triple fixed-dose combination</kwd><kwd>amlodipine</kwd><kwd>indapamide</kwd><kwd>perindopril</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И. Е. и соавт. Диагностика и лечение артериальной гипертонии. Клинические рекомендации/ МЗ РФ., Москва, 2013.-65 с.</mixed-citation><mixed-citation xml:lang="en">Чазова И. Е. и соавт. Диагностика и лечение артериальной гипертонии. Клинические рекомендации/ МЗ РФ., Москва, 2013.-65 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. Journal of hypertension 2013, 31: 1281-1357.</mixed-citation><mixed-citation xml:lang="en">Mancia G, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. Journal of hypertension 2013, 31: 1281-1357.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Муромцева Г. А., Концевая А. В., Константинов В. В. и соавт. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012-2013 гг. Результаты исследования ЭССЕ-РФ. Кардиоваскулярная терапия и профилактика, 2014; 13(6): 4-11.</mixed-citation><mixed-citation xml:lang="en">Муромцева Г. А., Концевая А. В., Константинов В. В. и соавт. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012-2013 гг. Результаты исследования ЭССЕ-РФ. Кардиоваскулярная терапия и профилактика, 2014; 13(6): 4-11.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">И. И. Чукаева, Н. В. Орлова, А. И. Хачирова, И. В. Комарова, С. В. Горяйнова, Н.Д. Карселадзе. Гендерные отличия жесткости стенки артерий у больных артериальной гипертонией и высоким суммарным сердечно-сосудистым риском. Вестник современной клинической медицины. - 2014.- Том 7.- вып. 3.- С. 35-38.</mixed-citation><mixed-citation xml:lang="en">И. И. Чукаева, Н. В. Орлова, А. И. Хачирова, И. В. Комарова, С. В. Горяйнова, Н.Д. Карселадзе. Гендерные отличия жесткости стенки артерий у больных артериальной гипертонией и высоким суммарным сердечно-сосудистым риском. Вестник современной клинической медицины. - 2014.- Том 7.- вып. 3.- С. 35-38.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jochmann N., Stangl K., Garbe E. et al. Female-specific aspects in the pharma cotherapy of chronic cardiovascular diseases // Eur. Heart. J. - 2005.- V. 26(16).- P. 1585-1595.</mixed-citation><mixed-citation xml:lang="en">Jochmann N., Stangl K., Garbe E. et al. Female-specific aspects in the pharma cotherapy of chronic cardiovascular diseases // Eur. Heart. J. - 2005.- V. 26(16).- P. 1585-1595.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yanes LL, Reckelhoff JF. Postmenopausal hypertension. Am J Hypertens. 2011;24:740-9.</mixed-citation><mixed-citation xml:lang="en">Yanes LL, Reckelhoff JF. Postmenopausal hypertension. Am J Hypertens. 2011;24:740-9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II) JAMA. 2002;288:49-57.</mixed-citation><mixed-citation xml:lang="en">Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II) JAMA. 2002;288:49-57.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">M. Brooks. Factors Driving High Blood Pressure Differ by Gender-Medscape - Oct 02,2017.</mixed-citation><mixed-citation xml:lang="en">M. Brooks. Factors Driving High Blood Pressure Differ by Gender-Medscape - Oct 02,2017.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tôth K; PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/ indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril- Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs 2014;14(2):137-45.</mixed-citation><mixed-citation xml:lang="en">Tôth K; PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/ indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril- Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs 2014;14(2):137-45.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pickering T. G., Shimbo D., Haas D. Ambulatory blood pressure monitoring // N. Engl. J. Med.- 2006.- Vol. 354, №22.- P. 2368-2374.</mixed-citation><mixed-citation xml:lang="en">Pickering T. G., Shimbo D., Haas D. Ambulatory blood pressure monitoring // N. Engl. J. Med.- 2006.- Vol. 354, №22.- P. 2368-2374.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., et al. Task Force Members and Document Reviewers (2016), 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail, 18:891-975. doi:10.1002/ejhf.592Tôth K</mixed-citation><mixed-citation xml:lang="en">Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., et al. Task Force Members and Document Reviewers (2016), 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail, 18:891-975. doi:10.1002/ejhf.592Tôth K</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs 2014;14(2):137-45</mixed-citation><mixed-citation xml:lang="en">PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs 2014;14(2):137-45</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
