medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2026-9-76-82medalphabet-5061Research ArticleСтатьиПищевая аллергия у детей с врожденным ихтиозомFood allergies in children with congenital ichthyosishttps://orcid.org/0009-0007-2418-4069МустафаеваД. И.MustafaevaD. I.

Мустафаева Динара Илгар кызы, аспирант, врач-педиатр приемно-диагностического отделения

Москва

Mustafaeva Dinara I., postgraduate student at Pediatrician of the Admission and Diagnostic Dept

Moscow

mustafaeva-dinara@mail.ruhttps://orcid.org/0000-0003-4759-3563МакароваС. Г.MakarovaS. G.

Макарова Светлана Геннадиевна, д. м. н., заместитель директора по научной работе, врач-аллерголог-иммунолог

Москва

Makarova Svetlana G., Dr Med Sci (habil.), deputy director for Research, allergist-immunologist

Moscow

sm27@yandex.ruhttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinN. N.

Мурашкин Николай Николаевич, д. м. н., профессор, заместитель директора по научной работе, заведующий отделениями дерматологии

Москва

Murashkin Nikolay N., Dr Med Sci (habil.), professor, deputy director for Research, head of Dermatology Dept

Moscow

m_nn2001@mail.ruhttps://orcid.org/0000-0002-9213-5281КурбатоваО. В.KurbatovaO. V.

Курбатова Ольга Владимировна, к. м. н., и. о. зав. лабораторией, врач клинической лабораторной диагностики, ведущий научный сотрудник

Москва

Kurbatova Olga V., PhD Med Sci, acting head of Laboratory, physician in Clinical Laboratory Diagnostics, leading researcher

Moscow

putintseva@mail.ruhttps://orcid.org/0000-0001-6648-2063ПушковА. А.PushkovA. A.

Пушков Александр Алексеевич, к. б. н., ведущий научный сотрудник лаборатории медицинской геномики

Москва

Pushkov Aleksandr A., PhD Bio Sci, leading researcher at the Laboratory of Medical Genomics

Moscow

pushkovgenetika@gmail.comhttps://orcid.org/0000-0002-7335-6329АветисянК. О.AvetisyanK. O.

Аветисян Карине Ониковна, врач-аллерголог-иммунолог, младший научный сотрудник лаборатории разработки новых технологий диагностики и лечения болезней детского возраста

Москва

Avetisyan Karine O., allergist-immunologist, junior researcher at the Laboratory for the Development of New Technologies for the Diagnosis and Treatment of Childhood Diseases

Moscow

avetisyan.karine@mail.ruhttps://orcid.org/0000-0002-5263-6743СновскаяМ. А.SnovskayaM. A.

Сновская Марина Андреевна, к. м. н., врач клинической лабораторной диагностики, ведущий научный сотрудник

Москва

Snovskaya Marina A., PhD Med Sci, leading researcher

Moscow

snows@inbox.ruhttps://orcid.org/0000-0002-6701-3872ГалимоваА. А.GalimovaA. A.

Галимова Альбина Альбертовна, к. м.н, старший научный сотрудник лаборатории клинической иммунологии и нутрициологии, врач-аллерголог-иммунолог

Москва

Galimova Albina A., PhD Med Sci, senior researcher at Laboratory of Clinical Immunology and Nutrition, allergist-immunologist

Moscow

albina86@yandex.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей»Russian FederationФГАУ «Национальный медицинский исследовательский центр здоровья детей»РоссияNational Medical Research Center of Children’s Health; I. M. Sechenov First Moscow State Medical University; Central State Medical Academy of the Administrative Department of the President of the Russian FederationRussian FederationФГАУ «Национальный медицинский исследовательский центр здоровья детей»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова» Минздрава России (Сеченовский университет); ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияNational Medical Research Center of Children’s HealthRussian FederationФГАУ «Национальный медицинский исследовательский центр здоровья детей»РоссияNational Medical Research Center of Children’s HealthRussian Federation20260106202609Диетология и нутрициология7682Copyright © Мустафаева Д.И., Макарова С.Г., Мурашкин Н.Н., Курбатова О.В., Пушков А.А., Аветисян К.О., Сновская М.А., Галимова А.А., 20262026Мустафаева Д.И., Макарова С.Г., Мурашкин Н.Н., Курбатова О.В., Пушков А.А., Аветисян К.О., Сновская М.А., Галимова А.А.Mustafaeva D.I., Makarova S.G., Murashkin N.N., Kurbatova O.V., Pushkov A.A., Avetisyan K.O., Snovskaya M.A., Galimova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/5061Актуальность

Актуальность. Врожденный ихтиоз (ВИ) – группа редких заболеваний кожи, характеризующихся нарушением кератинизации. Все формы ВИ связаны с нарушением барьерной функции кожи, что создает высокий риск транскутанной сенсибилизации к пищевым аллергенам и развития пищевой аллергии (ПА).

Цель

Цель: выявить особенности ПА у детей с различными формами ВИ.

Материалы и методы

Материалы и методы. Проведено амбиспективное исследование, включающее 61 ребенка с ВИ. Пациенты были разделены на 4 группы: I группа – 18 человек с синдромом Нетертона; II группа – 19 детей с аутосомно-рецессивной формой ВИ; III группа – 14 пациентов с кератинопатической формой ВИ; IV группа – 20 детей с вульгарным ихтиозом. Во всех группах проводилась оценка аллергологического анамнеза, уровня общего иммуноглобулина E, уровней специфических иммуноглобулинов E к 5 аллергенам, при необходимости – диагностическая диета и открытая провокационная проба.

Результаты

Результаты. При анализе уровней sIgE чаще встречалась сенсибилизация к яичному белку, коровьему молоку и треске. Наиболее высокая частота повышенных уровней sIgE выявлялась у детей I, II и IV групп. Пищевая аллергия встречалась во всех группах: в I группе – в 100,0%, во II группе – в 68,42%, в III группе – в 42,86%, в IV группе – в 90,0% случаев. Кожно-гастроинтестинальные симптомы ПА преобладали у детей I, II, III групп, для детей IV группы были более характерны кожные проявления ПА. Наиболее частыми клинически-значимыми пищевыми аллергенами были куриное яйцо, коровье молоко, глютенсодержащие продукты, рыба, орехи.

Выводы

Выводы. Полученные данные позволили оценить частоту развития и особенности коморбидной ПА у детей с различными формами ВИ.

Relevance

Relevance. Congenital ichthyosis (CI) is a group of rare skin diseases characterized by impaired keratinization. All forms of CI are associated with impaired skin barrier function, which creates a high risk of transcutaneous sensitization to food allergens and the development of food allergy (FA). Aim: to identify the features of FA in children with various forms of CI.

Materials and methods

Materials and methods. An ambispective study was conducted, including 61 children with CI. Patients were divided into 4 groups: Group I – 18 individuals with Netherton syndrome; Group II – 19 children with autosomal recessive CI; Group III – 14 patients with keratinopathic CI; Group IV – 20 children with ichthyosis vulgaris. In all groups, an assessment of allergic history, total immunoglobulin E levels, specific immunoglobulin E levels to 5 allergens was performed, and if necessary, a diagnostic diet and open food challenge were conducted.

Results

Results. Analysis of sIgE levels showed that sensitization to egg white, cow’s milk, and cod was most frequently observed. The highest frequency of elevated sIgE levels was found in children in Groups I, II, and IV. Food allergy occurred in all groups: in Group I – 100.0%, in Group II – 68.42%, in Group III – 42.86%, and in Group IV – 90.0% of cases. Cutaneous-gastrointestinal symptoms of FA predominated in children in Groups I, II, and III, while cutaneous manifestations of FA were more characteristic for children in Group IV. The most common clinically significant food allergens were chicken egg, cow’s milk, gluten-containing products, fish, and nuts.

Conclusions

Conclusions. The obtained data allowed for the assessment of the frequency and features of comorbid FA in children with various forms of CI.

врожденный ихтиозпищевая аллергиятранскутанная сенсибилизациядетиcongenital ichthyosisfood allergytranscutaneous sensitizationchildrenReferencesMurashkin N.N., Avetisyan K.O., Ivanov R.A., Makarova S.G. Congenital Ichthyosis: Clinical and Genetic Characteristics of the Disease. Current Pediatrics. 2022;21 (5): 362–377. (In Russ.). https://doi.org/10.15690/vsp.v21i5.2459Murashkin N.N., Avetisyan K.O., Ivanov R.A., Makarova S.G. Congenital Ichthyosis: Clinical and Genetic Characteristics of the Disease. Current Pediatrics. 2022;21 (5): 362–377. (In Russ.). https://doi.org/10.15690/vsp.v21i5.2459Vahlquist A, Törmä H. Ichthyosis: A Road Model for Skin Research. Acta Derm Venereol. 2020; 100 (7): adv00097. DOI: https://doi.org/10.2340/00015555–3433Vahlquist A, Törmä H. Ichthyosis: A Road Model for Skin Research. Acta Derm Venereol. 2020; 100 (7): adv00097. DOI: https://doi.org/10.2340/00015555–3433Sun Q, Burgren N.M, Cheraghlou S, Paller A.S, Larralde M, Bercovitch L, Levinsohn J, et al. The Genomic and Phenotypic Landscape of Ichthyosis: An Analysis of 1000 Kindreds. JAMA Dermatol. 2022 Jan 1; 158 (1):16–25. DOI: 10.1001/jamadermatol.2021.4242Sun Q, Burgren N.M, Cheraghlou S, Paller A.S, Larralde M, Bercovitch L, Levinsohn J, et al. The Genomic and Phenotypic Landscape of Ichthyosis: An Analysis of 1000 Kindreds. JAMA Dermatol. 2022 Jan 1; 158 (1):16–25. DOI: 10.1001/jamadermatol.2021.4242Egawa G. Pathomechanism of ‘skin-originated’ allergic diseases. Immunological Medicine. 2018; 41 (4), 170–176. https://doi.org/10.1080/25785826.2018.1540257Egawa G. Pathomechanism of ‘skin-originated’ allergic diseases. Immunological Medicine. 2018; 41 (4), 170–176. https://doi.org/10.1080/25785826.2018.1540257Werfel T, Allam JP, Biedermann T. et al. Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J. Allergy Clin Immunol. 2016; 138 (2): 336–349. DOI: 10.1016/j.jaci.2016.06.010 EDN: XTYENBWerfel T, Allam JP, Biedermann T. et al. Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J. Allergy Clin Immunol. 2016; 138 (2): 336–349. DOI: 10.1016/j.jaci.2016.06.010 EDN: XTYENBZhu TH, Zhu TR, Tran KA. et al. Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation. Br.J. Dermatol. 2018; 179 (3): 570–581. DOI: 10.1111/bjd.16734Zhu TH, Zhu TR, Tran KA. et al. Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation. Br.J. Dermatol. 2018; 179 (3): 570–581. DOI: 10.1111/bjd.16734Brough HA, Lanser BJ, Sindher SB. et al. Early intervention and prevention of allergic diseases. Allergy. 2022; 77 (2): 416–441. DOI: 10.1111/all.15006 EDN: QKTTVKBrough HA, Lanser BJ, Sindher SB. et al. Early intervention and prevention of allergic diseases. Allergy. 2022; 77 (2): 416–441. DOI: 10.1111/all.15006 EDN: QKTTVKLeung DYM, Berdyshev E, Goleva E. Cutaneous barrier dysfunction in allergic diseases. J. Allergy Clin Immunol. 2020; 145 (6): 1485–1497. DOI: 10.1016/j.jaci.2020.02.021 EDN: RRBRXLLeung DYM, Berdyshev E, Goleva E. Cutaneous barrier dysfunction in allergic diseases. J. Allergy Clin Immunol. 2020; 145 (6): 1485–1497. DOI: 10.1016/j.jaci.2020.02.021 EDN: RRBRXLLack G. Epidemiologic risks for food allergy. J. Allergy Clin Immunol. 2008; 121 (6): 1331–1336. DOI: 10.1016/j.jaci.2008.04.032Lack G. Epidemiologic risks for food allergy. J. Allergy Clin Immunol. 2008; 121 (6): 1331–1336. DOI: 10.1016/j.jaci.2008.04.032Pearson R.M., Casey L.M., Hughes K.R., Miller S.D., Shea L.D. In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance. Adv. Drug. Deliver Rev. 2017; 114: 240–255. DOI: 10.1016/j.addr.2017.04.005Pearson R.M., Casey L.M., Hughes K.R., Miller S.D., Shea L.D. In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance. Adv. Drug. Deliver Rev. 2017; 114: 240–255. DOI: 10.1016/j.addr.2017.04.005Novik G. A., Zhdanova M. V., Demidova A. S. Epicutaneous sensitization. What do we know? Bulletin of Siberian Medicine. 2021; 20 (4): 180–192. (In Russ.). https://doi.org/10.20538/1682-0363-2021-4-180-192Novik G. A., Zhdanova M. V., Demidova A. S. Epicutaneous sensitization. What do we know? Bulletin of Siberian Medicine. 2021; 20 (4): 180–192. (In Russ.). https://doi.org/10.20538/1682-0363-2021-4-180-192Yamamoto-Hanada K, Kobayashi T, Mikami M, Williams HC, Saito H, Saito-Abe M, Sato M, Irahara M, Miyaji Y, Ishikawa F, Tsuchiya K, Tamagawa-Mineoka R, Takaoka Y, Takemura Y, Sato S, Wakiguchi H, Hoshi M, Natsume O, Yamaide F, Seike M, Ohya Y. PACI Study Collaborators. Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy. J. Allergy Clin Immunol. 2023 Jul; 152 (1): 126–135. DOI: 10.1016/j.jaci.2023.03.008. Epub 2023 Mar 22.Yamamoto-Hanada K, Kobayashi T, Mikami M, Williams HC, Saito H, Saito-Abe M, Sato M, Irahara M, Miyaji Y, Ishikawa F, Tsuchiya K, Tamagawa-Mineoka R, Takaoka Y, Takemura Y, Sato S, Wakiguchi H, Hoshi M, Natsume O, Yamaide F, Seike M, Ohya Y. PACI Study Collaborators. Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy. J. Allergy Clin Immunol. 2023 Jul; 152 (1): 126–135. DOI: 10.1016/j.jaci.2023.03.008. Epub 2023 Mar 22.Kelleher MM, Dunn-Galvin A, Gray C. et al. Skin barrier impairment at birth predicts food allergy at 2 years of age. J. Allergy Clin Immunol. 2016; 137 (4): 1111–1116.e8. DOI: 10.1016/j.jaci.2015.12.1312Kelleher MM, Dunn-Galvin A, Gray C. et al. Skin barrier impairment at birth predicts food allergy at 2 years of age. J. Allergy Clin Immunol. 2016; 137 (4): 1111–1116.e8. DOI: 10.1016/j.jaci.2015.12.1312Murashkin N.N., Ivanov R.A., Savelova A.A., Fedorov D.V., Opryatin L.A., Ahmad W. Role of the Epidermal Barrier in the Formation of Food Allergies in Children with Genodermatosis. Pediatric pharmacology. 2019; 16 (4): 234–240. (In Russ.). https://doi.org/10.15690/pf.v16i4.2053Murashkin N.N., Ivanov R.A., Savelova A.A., Fedorov D.V., Opryatin L.A., Ahmad W. Role of the Epidermal Barrier in the Formation of Food Allergies in Children with Genodermatosis. Pediatric pharmacology. 2019; 16 (4): 234–240. (In Russ.). https://doi.org/10.15690/pf.v16i4.2053Guillet G, Guillet MH. Percutaneous sensitization to almond oil in infancy and study of ointments in 27 children with food allergy. Allerg Immunol (Paris). 2000; 32: 309–11.Guillet G, Guillet MH. Percutaneous sensitization to almond oil in infancy and study of ointments in 27 children with food allergy. Allerg Immunol (Paris). 2000; 32: 309–11.Lack G, Fox D, Northstone K, Golding J. Avon Longitudinal Study of Parents and Children Study Team. Factors associated with the development of peanut allergy in childhood. N Engl. J. Med. 2003 Mar 13; 348 (11): 977–85. DOI: 10.1056/NEJMoa013536. Epub 2003 Mar 10. PMID: 12637607.Lack G, Fox D, Northstone K, Golding J. Avon Longitudinal Study of Parents and Children Study Team. Factors associated with the development of peanut allergy in childhood. N Engl. J. Med. 2003 Mar 13; 348 (11): 977–85. DOI: 10.1056/NEJMoa013536. Epub 2003 Mar 10. PMID: 12637607.Boussault P, Leaute-Labreze C, Saubusse E. et al. Oat sensitization in children with atopic dermatitis: prevalence, risks and associated factors. Allergy. 2007; 62: 1251–6. DOI: 10.1111/j.1398-9995.2007.01527.xBoussault P, Leaute-Labreze C, Saubusse E. et al. Oat sensitization in children with atopic dermatitis: prevalence, risks and associated factors. Allergy. 2007; 62: 1251–6. DOI: 10.1111/j.1398-9995.2007.01527.xGalimova A.A. Food Allergy in Children with Congenital Epidermolysis Bullosa: Diss. … Cand. Med. Sci. Moscow, FSBI «National Medical Research Center of Children’s Health», 2025.Galimova A.A. Food Allergy in Children with Congenital Epidermolysis Bullosa: Diss. … Cand. Med. Sci. Moscow, FSBI «National Medical Research Center of Children’s Health», 2025.Astolfi A, Cipriani F, Messelodi D, De Luca M, Indio V, Di Chiara C, Giannetti A, Ricci L, Neri I, Patrizi A, Ricci G, Pession A. Filaggrin Loss-of-Function Mutations Are Risk Factors for Severe Food Allergy in Children with Atopic Dermatitis. J. Clin Med. 2021 Jan 11; 10 (2): 233. DOI: 10.3390/jcm10020233Astolfi A, Cipriani F, Messelodi D, De Luca M, Indio V, Di Chiara C, Giannetti A, Ricci L, Neri I, Patrizi A, Ricci G, Pession A. Filaggrin Loss-of-Function Mutations Are Risk Factors for Severe Food Allergy in Children with Atopic Dermatitis. J. Clin Med. 2021 Jan 11; 10 (2): 233. DOI: 10.3390/jcm10020233Stuvel K, Heeringa JJ, Dalm VASH. et al. Comel–Netherton syndrome: a local skin barrier defect in the absence of an underlying systemic immunodeficiency. Allergy. 2020; 75 (7): 1710–1720. DOI: 10.1111/all.14197 EDN: PPVICYStuvel K, Heeringa JJ, Dalm VASH. et al. Comel–Netherton syndrome: a local skin barrier defect in the absence of an underlying systemic immunodeficiency. Allergy. 2020; 75 (7): 1710–1720. DOI: 10.1111/all.14197 EDN: PPVICYScala E, Condorelli AG, Scala A. et al. IgE sensitization profile in patients with Netherton syndrome. Int Arch Allergy Immunol. 2022; 183 (12): 1291–1296. DOI: 10.1159/000526409 EDN: XHOPUHScala E, Condorelli AG, Scala A. et al. IgE sensitization profile in patients with Netherton syndrome. Int Arch Allergy Immunol. 2022; 183 (12): 1291–1296. DOI: 10.1159/000526409 EDN: XHOPUHBarbati F, Giovannini M, Oranges T. et al. Netherton syndrome in children: management and future perspective. Front Pediatr. 2021; 9: 645259. DOI: 10.3389/fped.2021.645259 EDN: JCFTWUBarbati F, Giovannini M, Oranges T. et al. Netherton syndrome in children: management and future perspective. Front Pediatr. 2021; 9: 645259. DOI: 10.3389/fped.2021.645259 EDN: JCFTWUKalb B, Marenholz I, Jeanrenaud ACSN, Meixner L, Arnau-Soler A, Rosillo-Salazar OD, Ghauri A, Cibin P, Blümchen K, Schlags R, Hansen G, Seidenberg J, Keil T, Lau S, Niggemann B, Beyer K, Lee YA. Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy. J. Allergy Clin Immunol. 2022 Nov; 150 (5): 1125–1134. DOI: 10.1016/j.jaci.2022.05.018Kalb B, Marenholz I, Jeanrenaud ACSN, Meixner L, Arnau-Soler A, Rosillo-Salazar OD, Ghauri A, Cibin P, Blümchen K, Schlags R, Hansen G, Seidenberg J, Keil T, Lau S, Niggemann B, Beyer K, Lee YA. Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy. J. Allergy Clin Immunol. 2022 Nov; 150 (5): 1125–1134. DOI: 10.1016/j.jaci.2022.05.018Brown SJ, Asai Y, Cordell HJ. et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J. Allergy Clin Immunol. 2011; 127: 661–7. DOI: 10.1016/j.jaci.2011.01.031Brown SJ, Asai Y, Cordell HJ. et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J. Allergy Clin Immunol. 2011; 127: 661–7. DOI: 10.1016/j.jaci.2011.01.031Namazova-Baranova LS. Allergiya u detei: ot teorii k praktike. Moscow: The Union of Pediatricians of Russia, 2010–2011. 668 p.Namazova-Baranova LS. Allergiya u detei: ot teorii k praktike. Moscow: The Union of Pediatricians of Russia, 2010–2011. 668 p.Food Allergy in Children and Adolescents: [Monograph] / S.G. Makarova, I.I. Balabolkin, A.P. Fisenko. Moscow: FSAI «National Medical Research Center for Children’s Health» of the Ministry of Health of Russia, 2021. 288 p. 27. Clinical Guidelines «Food Allergy» dated 23.12.2026. https://medpoint.pro/article/pishchevaya-allergiya-2166Food Allergy in Children and Adolescents: [Monograph] / S.G. Makarova, I.I. Balabolkin, A.P. Fisenko. Moscow: FSAI «National Medical Research Center for Children’s Health» of the Ministry of Health of Russia, 2021. 288 p. 27. Clinical Guidelines «Food Allergy» dated 23.12.2026. https://medpoint.pro/article/pishchevaya-allergiya-2166Molina-Infante J, Arias Á, Alcedo J, Garcia-Romero R, Casabona-Frances S, Prieto-Garcia A, Modolell I, Gonzalez-Cordero PL, Perez-Martinez I, Martin-Lorente JL, Guarner-Argente C, Masiques ML, Vila-Miravet V, Garcia-Puig R, Savarino E, Sanchez-Vegazo CT, Santander C, Lucendo AJ. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study. J. Allergy Clin Immunol. 2018 Apr; 141 (4): 1365–1372. DOI: 10.1016/j.jaci.2017.08.038Molina-Infante J, Arias Á, Alcedo J, Garcia-Romero R, Casabona-Frances S, Prieto-Garcia A, Modolell I, Gonzalez-Cordero PL, Perez-Martinez I, Martin-Lorente JL, Guarner-Argente C, Masiques ML, Vila-Miravet V, Garcia-Puig R, Savarino E, Sanchez-Vegazo CT, Santander C, Lucendo AJ. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study. J. Allergy Clin Immunol. 2018 Apr; 141 (4): 1365–1372. DOI: 10.1016/j.jaci.2017.08.038

The authors declare that there are no conflicts of interest present.