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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2026-10-108-113</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-5005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Корреляционная взаимосвязь между степенью скученного положения зубов, уровнем гигиены рта и концентрацией белка статерина в ротовой жидкости</article-title><trans-title-group xml:lang="en"><trans-title>Correlation between the degree of dental crowding, the level of oral hygiene, and the concentration of statherin protein in oral fluid</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7150-9216</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудник</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudnik</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олеся Викторовна Дудник, д. м. н., доцент, проф.</p><p>Институт стоматологии им. Е.В. Боровского; кафедра ортодонтии и профилактики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Olesya V. Dudnik, MD, PhD, Professor</p><p>E.V. Borovsky Institute of Dentistry; Department of Orthodontics and Prevention of Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">dudnik_o_v@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2932-168X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дыбов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dybov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Михайлович Дыбов, д. м. н., доцент, зав. кафедрой</p><p>Институт стоматологии им. Е.В. Боровского; кафедра ортодонтии и профилактики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Andrey M. Dybov, MD, PhD, Professor, Head of the Department</p><p>E.V. Borovsky Institute of Dentistry; Department of Orthodontics and Prevention of Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">dybov_a_m@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скакодуб</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Skakodub</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алла Анатольевна Скакодуб, д. м. н., доцент</p><p>Институт стоматологии им. Е.В. Боровского; кафедра ортодонтии и профилактики стоматологических заболеваний </p><p>Москва</p></bio><bio xml:lang="en"><p>Alla A. Skakodub, MD, PhD, Associate Professor</p><p>E.V. Borovsky Institute of Dentistry; Department of Orthodontics and Prevention of Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">skakodub_a_a@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-3287-1069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юйчэн</surname><given-names>Гао</given-names></name><name name-style="western" xml:lang="en"><surname>Yucheng</surname><given-names>Gao</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гао Юйчэн, аспирант</p><p>Институт стоматологии им. Е.В. Боровского; кафедра ортодонтии и профилактики стоматологических заболеваний </p><p>Москва</p></bio><bio xml:lang="en"><p>Gao Yucheng, Postgraduate Student</p><p>E.V. Borovsky Institute of Dentistry; Department of Orthodontics and Preventionof Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">2509247615@qq.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-3693-5283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цзининь</surname><given-names>Ли</given-names></name><name name-style="western" xml:lang="en"><surname>Jinging</surname><given-names>Li</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ли Цзининь, аспирант</p><p>Институт стоматологии им. Е.В. Боровского; кафедра ортодонтии и профилактики стоматологических заболеваний </p><p>Москва</p></bio><bio xml:lang="en"><p>Li Jinging, Postgraduate Student</p><p>E.V. Borovsky Institute of Dentistry; Department of Orthodontics and Preventionof Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">lbj993559@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>02</day><month>05</month><year>2026</year></pub-date><volume>0</volume><issue>10</issue><issue-title>Стоматология (2)</issue-title><fpage>108</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дудник О.В., Дыбов А.М., Скакодуб А.А., Юйчэн Г., Цзининь Л., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Дудник О.В., Дыбов А.М., Скакодуб А.А., Юйчэн Г., Цзининь Л.</copyright-holder><copyright-holder xml:lang="en">Dudnik O.V., Dybov A.M., Skakodub A.A., Yucheng G., Jinging L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/5005">https://www.med-alphabet.com/jour/article/view/5005</self-uri><abstract><sec><title>   Актуальность</title><p>   Актуальность. Скученное положение зубов является одной из наиболее распространенных зубочелюстных аномалий у детей и подростков, встречающейся у 35–65 % детей школьного возраста. Данная патология создает условия для повышенного образования зубного налета в труднодоступных для гигиены участках, что увеличивает риск развития кариеса и воспалительных заболеваний пародонта. Актуальность исследования обусловлена необходимостью разработки эффективных стратегий гигиенического ухода за полостью рта у детей со скученным положением зубов с учетом возрастных особенностей, степени выраженности аномалии и уровня развития мануальных навыков.</p></sec><sec><title>   Цель</title><p>   Цель. Повышение уровня гигиены полости рта у детей 6–12 лет со скученностью зубов за счет разработки алгоритма оптимизации индивидуальной гигиены полости рта с учетом концентрации белка статерина в ротовой жидкости как маркера минерального обмена.</p></sec><sec><title>   Материалы и методы</title><p>   Материалы и методы. Проведено обследование 60 детей в возрасте 6–12 лет (32 мальчика и 28 девочек), разделенных на две возрастные группы: 6-8 лет (n = 30) и 9-12 лет (n = 30). В каждой группе выделены подгруппы по степени скученности зубов (легкая, средняя, тяжелая). Определены гигиенические индексы Грина – Вермильона (OHI-S), индекс кровоточивости (PBI), папиллярно-маргинально-альвеолярный индекс (PMA). У 30 детей методом иммуноферментного анализа (ELISA) определена концентрация белка статерина в ротовой жидкости. Оценена эффективность трех типов зубных щеток (мануальная с ровным полем, мануальная с разноуровневым полем, электрическая) после однократной чистки и через 1 и 3 месяца использования. Статистическая обработка проведена с помощью программы Statistica 12.0.</p></sec><sec><title>   Результаты</title><p>   Результаты. Распространенность скученности зубов составила 68,3 % (41/60), с тенденцией к увеличению с возрастом (63,3 % в группе 6-8 лет и 73,3 % в группе 9-12 лет). Установлена прямая сильная корреляция между степенью скученности и значениями OHI-S (r = 0,72, p &lt; 0,01). Средние значения PMA достоверно возрастали с увеличением степени скученности: 14,8 ± 2,3 % (без скученности), 23,5 ± 3,1 % (легкая), 31,7 ± 3,8 % (средняя), 42,5 ± 4,7 % (тяжелая) (p &lt; 0,05). Концентрация статерина была достоверно выше у детей со скученностью (3,2 ± 0,4 ммоль/л в группе 6–8 лет и 3,9 ± 0,5 ммоль/л в группе 9–12 лет) по сравнению с детьми без патологии (2,7 ± 0,3 и 3,0 ± 0,3 ммоль/л соответственно) (p &lt; 0,05). У детей 6-8 лет мануальные щетки с разноуровневым полем и электрические щетки показали сопоставимую эффективность (редукция налета 68,4 ± 5,2 % и 70,8 ± 6,1 %), превосходя мануальные щетки с ровным полем (52,6 ± 4,7%, p &lt; 0,05). В группе 9-12 лет электрические щетки были наиболее эффективны (75,3 ± 5,8 %), превосходя мануальные щетки с разноуровневым (64,2 ± 5,0 %, p &lt; 0,05) и ровным (50,1 ± 4,5 %, p &lt; 0,01) полем. При использовании электрических щеток в течение 3 месяцев отмечено достоверное снижение концентрации статерина (на 22,5 ± 3,8 % в группе 6-8 лет и на 28,7 ± 4,2 % в группе 9–12 лет, p &lt; 0,05).</p></sec><sec><title>   Выводы</title><p>   Выводы. Установлена корреляция между степенью скученности зубов и уровнем гигиены полости рта. Концентрация белка статерина в ротовой жидкости может служить маркером риска и компенсаторным механизмом при скученном положении зубов. Разработан комплексный алгоритм выбора средств гигиены полости рта с учетом возраста, степени скученности и уровня мануальных навыков.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Background</title><p>   Background. Dental crowding is one of the most common dentofacial anomalies in children and adolescents, occurring in 35–65 % of school-age children. This pathology creates conditions for increased plaque formation in areas difficult to access for hygiene, increasing the risk of dental caries and inflammatory periodontal diseases. The relevance of this study is due to the need to develop effective strategies for oral hygiene care in children with dental crowding, taking into account age characteristics, severity of the anomaly, and level of manual skills development.</p></sec><sec><title>   Objective</title><p>   Objective. To improve the level of oral hygiene in children aged 6–12 years with dental crowding by developing an algorithm for optimizing individual oral hygiene, taking into account the concentration of statherin protein in oral fluid as a marker of mineral metabolism.</p></sec><sec><title>   Materials and methods</title><p>   Materials and methods. A study was conducted of 60 children aged 6–12 years (32 boys and 28 girls), divided into two age groups: 6–8 years (n = 30) and 9–12 years (n = 30). Subgroups were identified in each group according to the degree of dental crowding (mild, moderate, severe). Green – Vermillion hygiene indices (OHI-S), bleeding index (PBI), and papillary-marginal-alveolar index (PMA) were determined. In 30 children, the concentration of statherin protein in oral fluid was determined by enzyme immunoassay (ELISA). The effectiveness of three types of tooth-brushes (manual with flat bristle field, manual with multi-level bristle field, electric) was evaluated after single brushing and after 1 and 3 months of use. Statistical processing was performed using Statistica 12.0.</p></sec><sec><title>   Results</title><p>   Results. The prevalence of dental crowding was 68.3% (41/60), with a tendency to increase with age (63.3 % in the 6–8 years group and 73.3 % in the 9–12 years group). A strong direct correlation was established between the degree of crowding and OHI-S values (r = 0.72, p &lt; 0.01). Mean PMA values significantly increased with increasing severity of crowding: 14.8 ± 2.3 % (no crowding), 23.5 ± 3.1 % (mild), 31.7 ± 3.8 % (moderate), 42.5 ± 4.7 % (severe) (p &lt; 0.05). Statherin concentration was significantly higher in children with crowding (3.2 ± 0.4 mmol/L in the 6-8 years group and 3.9 ± 0.5 mmol/L in the 9-12 years group) compared to children without pathology (2.7 ± 0.3 and 3.0 ± 0.3 mmol/L, respectively) (p &lt; 0.05). In children aged 6-8 years, manual brushes with multi-level bristle field and electric brushes showed comparable effectiveness (plaque reduction 68.4 ± 5.2 % and 70.8 ± 6.1 %), surpassing manual brushes with flat field (52.6 ± 4.7 %, p &lt; 0.05). In the 9–12 years group, electric brushes were most effective (75.3 ± 5.8 %), surpassing manual brushes with multi-level (64.2 ± 5.0 %, p &lt; 0.05) and flat (50.1 ± 4.5 %, p &lt; 0.01) fields. When using electric brushes for 3 months, a significant decrease in statherin concentration was noted (by 22.5 ± 3.8 % in the 6–8 years group and by 28.7 ± 4.2 % in the 9–12 years group, p &lt; 0.05).</p></sec><sec><title>   Conclusion</title><p>   Conclusion. A correlation has been established between the degree of dental crowding and the level of oral hygiene. The concentration of statherin protein in oral fluid can serve as a risk marker and compensatory mechanism in dental crowding. A comprehensive algorithm for selecting oral hygiene products has been developed, taking into account age, degree of crowding, and level of manual skills.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гигиена полости рта</kwd><kwd>дети</kwd><kwd>зубочелюстные аномалии</kwd><kwd>пубертатный период</kwd><kwd>скученность зубов</kwd><kwd>стоматологический статус</kwd><kwd>белок статерин</kwd><kwd>электрические зубные щетки</kwd><kwd>индекс OHI-S</kwd><kwd>профилактика стоматологических заболеваний</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oral hygiene</kwd><kwd>children</kwd><kwd>dentofacial anomalies</kwd><kwd>puberty</kwd><kwd>dental crowding</kwd><kwd>dental status</kwd><kwd>statherin protein</kwd><kwd>electric toothbrushes</kwd><kwd>OHI-S index</kwd><kwd>prevention of dental diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Асанова Н.Б., Алымбаева А.С., Алымбаев Р.С. 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