medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2026-3-94-98medalphabet-4960Research ArticleСтатьиНаучно-практические аспекты и перспективы применения эмолента+ LIPIKAR BAUME AP+MAX® (резолюция консилиума экспертов)Scientific and practical aspects and prospects for the use of emolent+ LIPIKAR BAUME AP+MAX® (resolution of the council of experts)https://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., профессор, зав. кафедрой дерматовенерологии и косметологии, ректор

Москва

Kruglova Larisa S., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, rector

Moscow 

kruglovals@mail.ruhttps://orcid.org/0000-0002-6378-8582АравийскаяЕ. Р.AraviyskayaE. A.

Аравийская Елена Александровна, д.м.н., профессор кафедры дерматовенерологии с клиникой, руководитель последипломного цикла обучения по косметологии для врачей, консультант

Санкт-Петербург 

Araviyskaya Elena A., Dr Med Sci (habil.), pofessor at Dept of Dermatovenereology with a Clinic, head of the Postgraduate Training Course in Cosmetology for doctors, consultant

Saint Petersburg 

arelenar@mail.ruhttps://orcid.org/0000-0002-3875-4030ЛьвовА. Н.LvovA. N.

Львов Андрей Николаевич, д.м.н., руководитель отдела аспирантуры и ординатуры, профессор кафедры дерматовенерологии и косметологии, главный научный сотрудник

Москва

Lvov Andrey N., Dr Med Sci (habil.), head of Postgraduate and Residency Studies, professor at Dept of Dermatovenereology and Cosmetology, chief researcher

Moscow 

alvov@mail.ruhttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinN. N.

Мурашкин Николай Николаевич, д.м.н., профессор, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей, руководитель НИИ детской дерматологии, профессор кафедры дерматовенерологии и косметологии

Москва

Murashkin Nikolai N., Dr Med Sci (habil.), professor, head of Dept of Dermatology with Laser Surgery Group, head of the Laboratory of Pediatric Skin Pathology, head of the Research Institute of Pediatric Dermatology, professor at Dept of Dermatovenereology and Cosmetology

Moscow 

https://orcid.org/0000-0001-7610-6061СоколовскийЕ. В.SokolovskyE. V.

Соколовский Евгений Владиславович, д.м.н., профессор, заведующий кафедрой дерматовенерологии с клиникой

Санкт-Петербург 

Sokolovsky Evgeny V., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology with a Clinic

Saint Petersburg 

s40@mail.ruhttps://orcid.org/0000-0002-0238-6563ШатохинаЕ. А.ShatokhinaE. A.

Шатохина Евгения Афанасьевна, д.м.н, профессор кафедры дерматовенерологии и косметологии, научный сотрудник

Москва

Shatokhina Evgenia A., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology, researcher

Moscow 

e.a.shatokhina@gmail.comФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of the Russian FederationRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России ; Институт красоты «ГАЛАКТИКА»РоссияPavlov First State Medical University of St. Petersburg (Pavlov University) ; GALAKTIKA Beauty InstituteRussian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации ; ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияCentral State Medical Academy of the Administrative Department of the President of the Russian Federation ; Lomonosov Moscow State UniversityRussian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации ; ФГАУ «Научный центр здоровья детей» Минздрава РоссииРоссияCentral State Medical Academy of the Administrative Department of the President of the Russian Federation ; Scientific Center for Children’s HealthRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияPavlov First State Medical University of St. Petersburg (Pavlov University)Russian Federation20261404202603Дерматология (1)9498Copyright © Круглова Л.С., Аравийская Е.Р., Львов А.Н., Мурашкин Н.Н., Соколовский Е.В., Шатохина Е.А., 20262026Круглова Л.С., Аравийская Е.Р., Львов А.Н., Мурашкин Н.Н., Соколовский Е.В., Шатохина Е.А.Kruglova L.S., Araviyskaya E.A., Lvov A.N., Murashkin N.N., Sokolovsky E.V., Shatokhina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4960

18 декабря 2025 года в Москве проводился консилиум экспертов на тему: «Практические аспекты и перспективы применения эмолента LIPIKAR BAUME AP+MAX®». Данное научное мероприятие стало площадкой для обсуждения вопросов о микробиоме кожи и ее роли в патогенезе хронических кожных заболеваний, в частности атопического дерматита, с учетом современных научных данных. В рамках консилиума также обсуждались вопросы применения нового эмолента+ LIPIKAR BAUME AP+MAX® в алгоритмах ведения пациентов с атопическим дерматитом с позиции современных клинических протоколов. Предметом дискуссии стали вопросы механизмов формирования зуда при атопическом дерматите, а также связи ксероза, воспаления и зуда в свете перспектив применения эмолентов+. Были обсуждены данные об эффективности применения нового эмолента+ LIPIKAR BAUME AP+MAX® у пациентов с атопическим дерматитом.

On December 18, 2025, an expert consultation on «Practical Aspects and Prospects for the Use of the Emollient LIPIKAR BAUME AP+MAX®» was held in Moscow. This scientific event provided a platform for discussing the skin microbiome and its role in the pathogenesis of chronic skin diseases, particularly atopic dermatitis, taking into account current scientific data. The consultation also addressed the use of the new emollient+ LIPIKAR BAUME AP+MAX® in patient management algorithms for atopic dermatitis, based on current clinical protocols. The discussion focused on the mechanisms of itching in atopic dermatitis, as well as the relationship between xerosis and itching in light of the prospects for the use of emollients+. Data on the effectiveness of the new emollient+ LIPIKAR BAUME AP+MAX® in patients with atopic dermatitis were also discussed.

микробиомбарьерная функция кожизудатопический дерматитэмоленты+наружное средство LIPIKAR BAUME AP+MAX®microbiomeskin barrier functionitchingatopic dermatitisemollients+topical agent LIPIKAR BAUME AP+MAX®ReferencesProksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier.Exp Dermatol 2008; 17: 1063–1072.Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier.Exp Dermatol 2008; 17: 1063–1072.Luebberding S, Krueger N, Kerscher M. Age-related changes in skin barrier function – quantitative evaluation of 150 female subjects. Int J Cosmet Sci 2013; 35: 183–190.Luebberding S, Krueger N, Kerscher M. Age-related changes in skin barrier function – quantitative evaluation of 150 female subjects. Int J Cosmet Sci 2013; 35: 183–190.Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sc 2006; 28: 359–370.Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sc 2006; 28: 359–370.Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006; 19: 296–302.Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006; 19: 296–302.Jurakić Tončić R, Marinović B. The Role of Impaired Epidermal Barrier Function in Atopic Dermatitis. Acta Dermatovenerol Croat. 2016; 24: 95–109.Jurakić Tončić R, Marinović B. The Role of Impaired Epidermal Barrier Function in Atopic Dermatitis. Acta Dermatovenerol Croat. 2016; 24: 95–109.Thawer-Esmail F. Skin barrier function and atopic eczema. Curr Allergy Clin Immunol 2011; 24: 1938.Thawer-Esmail F. Skin barrier function and atopic eczema. Curr Allergy Clin Immunol 2011; 24: 1938.Jurakic T.R., Sanja K., Ljubojevic H.S., Branka М. Skin Barrier and Dry Skin in the Mature Patient, Clinics in Dermatology (2017). DOI: 10.1016/j.clindermatol.2017.10.002Jurakic T.R., Sanja K., Ljubojevic H.S., Branka М. Skin Barrier and Dry Skin in the Mature Patient, Clinics in Dermatology (2017). DOI: 10.1016/j.clindermatol.2017.10.002De Benedetto A, Agnihothri R, McGirt LY, Bankova LG, Beck LA. Atopic dermatitis: a disease caused by innate immune defects? J Invest Dermatol 2009; 129: 14–30.De Benedetto A, Agnihothri R, McGirt LY, Bankova LG, Beck LA. Atopic dermatitis: a disease caused by innate immune defects? J Invest Dermatol 2009; 129: 14–30.Ladd M, Sharma A, Huang Q, Wang AY, Xu L, Genowati I, et al. Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation. Immunology 2010; 131: 289–299.Ladd M, Sharma A, Huang Q, Wang AY, Xu L, Genowati I, et al. Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation. Immunology 2010; 131: 289–299.Skabytska Y, Kaesler S, Volz T, Biedermann T. The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments. Semin Immunopathol. 2016; 38: 29–43.Skabytska Y, Kaesler S, Volz T, Biedermann T. The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments. Semin Immunopathol. 2016; 38: 29–43.Two AM, Nakatsuji T, Kotol PF, Arvanitidou E, Du-Thumm L, Hata TR, et al. The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers. J Invest Dermatol 2016; 136: 1950–1954.Two AM, Nakatsuji T, Kotol PF, Arvanitidou E, Du-Thumm L, Hata TR, et al. The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers. J Invest Dermatol 2016; 136: 1950–1954.Schommer NN, Gallo RL. Structure and function of the human skin microbiome. Trends Microbiol 2013; 21:660–668. Gallo RL, Hooper LV.Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol 2012; 12: 503–516.Schommer NN, Gallo RL. Structure and function of the human skin microbiome. Trends Microbiol 2013; 21:660–668. Gallo RL, Hooper LV.Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol 2012; 12: 503–516.Kuo I et al. The cutaneous innate immune response in patients with atopic dermatitisJ Allergy Clin Immunol 2013; 131: 266–278.Kuo I et al. The cutaneous innate immune response in patients with atopic dermatitisJ Allergy Clin Immunol 2013; 131: 266–278.Kezic S, O’Regan GM, Lutter R, et al. Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol. 2012; 129 (4): 1031–1039.e1.Kezic S, O’Regan GM, Lutter R, et al. Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol. 2012; 129 (4): 1031–1039.e1.Yoshida K, Kubo A, Fujita H, et al. Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis. J Allergy Clin Immunol. 2014; 134 (4): 856–864.Yoshida K, Kubo A, Fujita H, et al. Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis. J Allergy Clin Immunol. 2014; 134 (4): 856–864.Czarnowicki T, Krueger JG, Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol. 2017; 139 (6): 1723–1734.Czarnowicki T, Krueger JG, Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol. 2017; 139 (6): 1723–1734.Demessant-Flavigny AL, et al. Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review. J Eur Acad Dermatol Venereol. 2023 Jun;37 Suppl 5:3–17. DOI: 10.1111/jdv.19125. PMID: 37232427.Demessant-Flavigny AL, et al. Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review. J Eur Acad Dermatol Venereol. 2023 Jun;37 Suppl 5:3–17. DOI: 10.1111/jdv.19125. PMID: 37232427.Ogonowska P, et al. Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown. Front Microbiol. 2021 Jan 11; 11: 567090. DOI: 10.3389/fmicb.2020.567090. PMID: 33505363; PMCID: PMC7830525.Ogonowska P, et al. Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown. Front Microbiol. 2021 Jan 11; 11: 567090. DOI: 10.3389/fmicb.2020.567090. PMID: 33505363; PMCID: PMC7830525.Kim J, Kim BE, Ahn K, Leung DYM. Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications. Allergy Asthma Immunol Res. 2019; 11 (5): 593–603. DOI: 10.4168/aair.2019.11.5.593Kim J, Kim BE, Ahn K, Leung DYM. Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications. Allergy Asthma Immunol Res. 2019; 11 (5): 593–603. DOI: 10.4168/aair.2019.11.5.593Joshi AA, Vocanson M, Nicolas JF, Wolf P, Patra V. Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis. Front Immunol. 2023; 14: 1125635. Published 2023 Jan 25. DOI: 10.3389/fimmu.2023.1125635Joshi AA, Vocanson M, Nicolas JF, Wolf P, Patra V. Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis. Front Immunol. 2023; 14: 1125635. Published 2023 Jan 25. DOI: 10.3389/fimmu.2023.1125635Geoghegan, Joan A.; Irvine, Alan D.; Foster, Timothy J. . (2017). Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends in Microbiology, (), S0966842X17302573–. DOI: 10.1016/j.tim.2017.11.008Geoghegan, Joan A.; Irvine, Alan D.; Foster, Timothy J. . (2017). Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends in Microbiology, (), S0966842X17302573–. DOI: 10.1016/j.tim.2017.11.008Papanikolaou M, Paul J, Nattkemper LA, Kirsner RS, Yosipovitch G. Prevalence and Mechanisms of Itch in Chronic Wounds: A Narrative Review. J Clin Med. 2025 Apr 22; 14 (9): 2877. DOI: 10.3390/jcm14092877. PMID: 40363908; PMCID: PMC 12072805.Papanikolaou M, Paul J, Nattkemper LA, Kirsner RS, Yosipovitch G. Prevalence and Mechanisms of Itch in Chronic Wounds: A Narrative Review. J Clin Med. 2025 Apr 22; 14 (9): 2877. DOI: 10.3390/jcm14092877. PMID: 40363908; PMCID: PMC 12072805.Özdemіr E, Öksüz L. Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis. Arch Microbiol. 2024 Sep 20; 206 (10): 410. DOI: 10.1007/s00203–024–04134-w. PMID: 39302484.Özdemіr E, Öksüz L. Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis. Arch Microbiol. 2024 Sep 20; 206 (10): 410. DOI: 10.1007/s00203–024–04134-w. PMID: 39302484.Kline SN, Saito Y, Archer NK. Staphylococcus aureus Proteases: Orchestrators of Skin Inflammation. DNA Cell Biol. 2024 Oct; 43 (10): 483–491. DOI: 10.1089/dna.2024.0134. Epub 2024 Jul 3. PMID: 38957987; PMCID: PMC11535466.Kline SN, Saito Y, Archer NK. Staphylococcus aureus Proteases: Orchestrators of Skin Inflammation. DNA Cell Biol. 2024 Oct; 43 (10): 483–491. DOI: 10.1089/dna.2024.0134. Epub 2024 Jul 3. PMID: 38957987; PMCID: PMC11535466.Wong LS, Yen YT, Lee CH. The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis. Int J Mol Sci. 2021 Jul 5; 22 (13): 7227. DOI: 10.3390/ijms22137227. PMID: 34281281; PMCID: PMC8269281Wong LS, Yen YT, Lee CH. The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis. Int J Mol Sci. 2021 Jul 5; 22 (13): 7227. DOI: 10.3390/ijms22137227. PMID: 34281281; PMCID: PMC8269281Laccourreye O, Maisonneuve H. French scientific medical journals confronted by developments in medical writing and the transformation of the medical press. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov; 136 (6): 475–480. DOI: 10.1016/j.anorl.2019.09.002. Epub 2019 Sep 17. PMID: 31540851.Laccourreye O, Maisonneuve H. French scientific medical journals confronted by developments in medical writing and the transformation of the medical press. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov; 136 (6): 475–480. DOI: 10.1016/j.anorl.2019.09.002. Epub 2019 Sep 17. PMID: 31540851.Tominaga M, Takamori K. Peripheral itch sensitization in atopic dermatitis. Allergol Int. 2022 Jul;71(3):265–277. DOI: 10.1016/j.alit.2022.04.003. Epub 2022 May 25. PMID: 35624035.Tominaga M, Takamori K. Peripheral itch sensitization in atopic dermatitis. Allergol Int. 2022 Jul;71(3):265–277. DOI: 10.1016/j.alit.2022.04.003. Epub 2022 May 25. PMID: 35624035.Gallo, R. L., & Horswill, A. R. (2024). Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis. In Journal of Investigative Dermatology (Vol. 144, Issue 5, pp. 950–953). Elsevier B.V. https://doi.org/10.1016/j.jid.2024.01.001.Gallo, R. L., & Horswill, A. R. (2024). Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis. In Journal of Investigative Dermatology (Vol. 144, Issue 5, pp. 950–953). Elsevier B.V. https://doi.org/10.1016/j.jid.2024.01.001.Deng, L., et al. (2023). S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR 1 axis. Cell, 186 (24), 5375–5393.e25. https://doi.org/10.1016/j.cell.2023.10.019Deng, L., et al. (2023). S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR 1 axis. Cell, 186 (24), 5375–5393.e25. https://doi.org/10.1016/j.cell.2023.10.019Wollenberg A, et al. European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy. J Eur Acad Dermatol Venereol. 2022 Sep; 36 (9): 1409–1431. DOI: 10.1111/jdv.18345. PMID: 35980214.Wollenberg A, et al. European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy. J Eur Acad Dermatol Venereol. 2022 Sep; 36 (9): 1409–1431. DOI: 10.1111/jdv.18345. PMID: 35980214.Dumbuya H, et al. INDIVIDUAL ARTICLE: Atopic Dermatitis Skincare and Impact on Quality of Life for Patients with Skin of Color. J Drugs Dermatol. 2024 Mar 1; 23 (3): SF395747s6-SF395747s11. DOI: 10.36849/jdd.SF395747. PMID: 38443136.Dumbuya H, et al. INDIVIDUAL ARTICLE: Atopic Dermatitis Skincare and Impact on Quality of Life for Patients with Skin of Color. J Drugs Dermatol. 2024 Mar 1; 23 (3): SF395747s6-SF395747s11. DOI: 10.36849/jdd.SF395747. PMID: 38443136.Wollenberg A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol. 2018 Jun; 32 (6): 850–878. DOI: 10.1111/jdv.14888. PMID: 29878606.Wollenberg A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol. 2018 Jun; 32 (6): 850–878. DOI: 10.1111/jdv.14888. PMID: 29878606.Araviiskaia E, et al. The Role of a Novel Generation of Emollients, ’Emollients Plus’, in Atopic Dermatitis. Clin Cosmet Investig Dermatol. 2022; 15: 2705–2719.Araviiskaia E, et al. The Role of a Novel Generation of Emollients, ’Emollients Plus’, in Atopic Dermatitis. Clin Cosmet Investig Dermatol. 2022; 15: 2705–2719.Mahe et al. A novel Vitreoscilla filiformis extract grown in spa water-enriched media activates endogenous cutaneous antioxidant and antimicrobial defenses via the potent Toll-like receptor 2/protein kinase C zeta transduction pathway.New Clin Cosmet Investig Dermatol. 2013 30; 6: 191–6.Mahe et al. A novel Vitreoscilla filiformis extract grown in spa water-enriched media activates endogenous cutaneous antioxidant and antimicrobial defenses via the potent Toll-like receptor 2/protein kinase C zeta transduction pathway.New Clin Cosmet Investig Dermatol. 2013 30; 6: 191–6.Gueniche et al. 2007.JEADV 22 (6): 746–747.Gueniche et al. 2007.JEADV 22 (6): 746–747.Gueniche et al. Br J Dermatol. 2008 Dec; 159 (6): 1357–63.Gueniche et al. Br J Dermatol. 2008 Dec; 159 (6): 1357–63.Augustin M, Langenbruch A, Blome C, et al. Characterizing treatment-related patient needs in atopic eczema: insights for personalized goal orientation. J Eur Acad Dermatol Venereol. 2020; 34 (1): 142–152.Augustin M, Langenbruch A, Blome C, et al. Characterizing treatment-related patient needs in atopic eczema: insights for personalized goal orientation. J Eur Acad Dermatol Venereol. 2020; 34 (1): 142–152.Reza M. Namazi Nicotinamide as a potential addition to the anti-atopic dermatitis armamentarium. International Immunopharmacology 2004 June; 4 (6): 709–712.Reza M. Namazi Nicotinamide as a potential addition to the anti-atopic dermatitis armamentarium. International Immunopharmacology 2004 June; 4 (6): 709–712.Tanno O et al. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol, 143 (3), 525–531, 2000.Tanno O et al. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol, 143 (3), 525–531, 2000.Zeichner and Seite. From Probiotic to Prebiotic Using Thermal Spring Water. 2018. JDD. 17 (6): 49–54.Zeichner and Seite. From Probiotic to Prebiotic Using Thermal Spring Water. 2018. JDD. 17 (6): 49–54.

The authors declare that there are no conflicts of interest present.