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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2026-3-67-71</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4951</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Лечебно-диагностическая стратегия при ведении больных с акне, с учетом коморбидности</article-title><trans-title-group xml:lang="en"><trans-title>A treatment and diagnostic strategy for managing patients with acne, considering comorbidity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Круглова Лариса Сергеевна, д.м.н., профессор, заведующая кафедрой дерматовенерологии и косметологии, ректор</p><p>Москва</p></bio><bio xml:lang="en"><p>Kruglova Larisa S., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, rector</p><p>Moscow </p></bio><email xlink:type="simple">kruglovals@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4920-5288</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ольховская</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Olkhovskaya</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольховская Кира Брониславовна, к.м.н., доцент кафедры дерматовенерологии и косметологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Olkhovskaya Kira B., PhD Med, associate professor at Dept of Dermatovenereology and Cosmetology</p><p>Moscow </p></bio><email xlink:type="simple">olhovskaya_kira@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быканов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bykanov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Быканов Александр Сергеевич, дерматолог, врач-косметолог, дерматовенеролог, детский дерматолог</p><p>Москва</p></bio><bio xml:lang="en"><p>Bykanov Alexander Sergeevich, dermatologist, cosmetologist, dermatovenerologist, pediatric dermatologist</p><p>Moscow </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>14</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>3</issue><issue-title>Дерматология (1)</issue-title><fpage>67</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Круглова Л.С., Ольховская К.Б., Быканов А.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Круглова Л.С., Ольховская К.Б., Быканов А.С.</copyright-holder><copyright-holder xml:lang="en">Kruglova L.S., Olkhovskaya K.B., Bykanov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4951">https://www.med-alphabet.com/jour/article/view/4951</self-uri><abstract><p>Акне – мультифакториальное заболевание, которое развивается в результате взаимодействия большого количества этиологических факторов. Основные звенья патофизиологии заболевания изучены достаточно хорошо, однако нередко врачи дерматовенерологи отмечают фармакорезистентность больных акне к традиционной проводимой терапии, что может быть обусловлено наличием коморбидной патологии и приемом лекарственных препаратов. В данной статье представлен систематизированный обзор наиболее частых сопутствующих заболеваний, обусловливающих спектр диагностического поиска и терапевтических возможностей при сочетанном течении акне.</p></abstract><trans-abstract xml:lang="en"><p>Acne is a multifactorial disease that develops as a result of the interaction of numerous etiologic factors. The key pathophysiological factors of the disease are well understood; however, dermatovenerologists often note that acne patients are resistant to traditional therapy, which may be due to comorbid conditions and medications. This article presents a systematic review of the most common comorbidities, which determine the range of diagnostic tests and therapeutic options for the combined course of acne.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акне</kwd><kwd>коморбидность</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>изотретиноин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acne</kwd><kwd>comorbidity</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>isotretinoin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dréno B. What is new in the pathophysiology of acne, an overview. J Eur Acad Dermatol Venereol. 2017 Sep; 31 (5): 8–12. https://doi.org/10.1111/jdv.14374</mixed-citation><mixed-citation xml:lang="en">Dréno B. What is new in the pathophysiology of acne, an overview. 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