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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2026-1-44-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4908</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Ультразвуковая диагностика поднижнечелюстных слюнных желез у пациентов с акромегалией</article-title><trans-title-group xml:lang="en"><trans-title>Ultrasound diagnostics of the submandibular salivary glands in patients with acromegaly</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5276-3873</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эфендиев</surname><given-names>Э. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Efendiev</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эфендиев Эмир Муслимович – аспирант кафедры хирургической стоматологии и имплантологии</p><p>AuthorID: 1327168</p><p>Москва</p></bio><bio xml:lang="en"><p>Efendiev E.M. – Postgraduate student, Department of Surgical Dentistry and Implantology</p><p>AuthorID: 1327168</p><p>Moscow</p></bio><email xlink:type="simple">efendiev_199@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9105-0796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амхадова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Amkhadova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Амхадова Малкан Абдрашидовна – д.м.н., профессор кафедры хирургической стоматологии и имплантологии</p><p>AuthorID: 259452</p><p>Москва</p></bio><bio xml:lang="en"><p>Amkhadova M.A. – Doctor of Medical Sciences, Professor, Head of the Department of Surgical Dentistry and Implantology</p><p>AuthorID: 259452</p><p>Moscow</p></bio><email xlink:type="simple">amkhadova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1592-7584</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сизова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sizova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сизова Анна Николаевна – к.м.н., ассистент кафедры оперативной хирургии и топографической анатомии</p><p>AuthorID: 926991</p><p>Москва</p></bio><bio xml:lang="en"><p>Sizova A.N. – Candidate of Medical Sciences, Assistant, Department of Operative Surgery and Topographic Anatomy</p><p>AuthorID: 926991</p><p>Moscow</p></bio><email xlink:type="simple">sizovaan2@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research Clinical Institute n. a. M. F. Vladimirsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Russian University of Medicine» of The Ministry of Health of The Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>02</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>1</issue><issue-title>Стоматология (1)</issue-title><fpage>44</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Эфендиев Э.М., Амхадова М.А., Сизова А.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Эфендиев Э.М., Амхадова М.А., Сизова А.Н.</copyright-holder><copyright-holder xml:lang="en">Efendiev E.M., Amkhadova M.A., Sizova A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4908">https://www.med-alphabet.com/jour/article/view/4908</self-uri><abstract><p>Введение. Акромегалия вызывает системные тканевые изменения и коморбидные состояния, в том числе со стороны органов-мишеней, включая слюнные железы. Ультразвуковая диагностика поднижнечелюстных слюнных желез (ПСЖ) позволяет количественно оценивать линейные размеры и расчетный объем. Цель: сравнить ультразвуковые показатели ПСЖ у пациентов с акромегалией и у лиц без акромегалии, а также оценить связь клинических факторов с ультразвуковой морфометрией ПСЖ в группе акромегалии. Материалы и методы. Проведено одноцентровое наблюдательное исследование. В анализ включены 68 участников: 41 пациент с акромегалией и 27 человек контрольной группы. При ультразвуковом исследовании измеряли длину, ширину и толщину поднижнечелюстных слюнных желез (ПСЖ) справа и слева. Объем каждой железы рассчитывали по формуле эллипсоида: V = (длина × ширина × толщина) × π/6. Основным показателем служил суммарный объем ПСЖ (Vсумм = объем правой железы + объем левой железы). Данные представлены как Me [Q1; Q3]. Для сравнения групп применяли критерий Манна – Уитни. Результаты. Суммарный объем поднижнечелюстных слюнных желез у пациентов с акромегалией был статистически значимо больше, чем в контрольной группе: 18,07 [12,80; 23,50] см³ против 13,60 [10,95; 14,50] см³ (p&lt;0,001). В группе акромегалии суммарный объем ПСЖ был статистически значимо больше у мужчин, чем у женщин (p&lt;0,001). При наличии гиперпролактинемии суммарный объем ПСЖ был статистически значимо ниже (p=0,0133). Заключение. При акромегалии по данным УЗ-морфометрии суммарный объем ПСЖ выше, чем в контрольной группе. Внутри группы акромегалии показатели ПСЖ различались по полу и статусу гиперпролактинемии, что следует учитывать при интерпретации ультразвуковых показателей.</p></abstract><trans-abstract xml:lang="en"><p>Background. Acromegaly causes systemic tissue changes and comorbid conditions involving target organs, including the salivary glands. Ultrasound examination of the submandibular salivary glands (SSG) enables quantitative assessment of linear dimensions and calculated volume. Objective: to compare ultrasound parameters of the SSG in patients with acromegaly and in individuals without acromegaly, and to assess the association between clinical factors and ultrasound morphometry of the SSG within the acromegaly group. Materials and methods. A single-center observational study was conducted. The analysis included 68 participants: 41 patients with acromegaly and 27 controls. On ultrasound, the length, width, and thickness of the right and left SSG were measured. The volume of each gland was calculated using the ellipsoid formula: V = (length × width × thickness) × π/6. The primary parameter was total SSG volume (Vtotal = right gland volume + left gland volume). Data are presented as Me [Q1; Q3]. The Mann – Whitney U test was used for group comparisons. Results. Total SSG volume in patients with acromegaly was significantly higher than in controls: 18.07 [12.80; 23.50] cm³ vs 13.60 [10.95; 14.50] cm³ (p&lt;0.001). Within the acromegaly group, total SSG volume was significantly higher in men than in women (p&lt;0.001). In the presence of hyperprolactinemia, total SSG volume was significantly lower (p=0.0133). Conclusion. According to ultrasound morphometry, total SSG volume is higher in acromegaly than in controls. Within the acromegaly group, SSG parameters differed by sex and hyperprolactinemia status, which should be considered when interpreting the measurements.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акромегалия</kwd><kwd>слюнные железы</kwd><kwd>ультразвуковое исследование</kwd><kwd>гиперпролактинемия</kwd><kwd>ИФР-1</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acromegaly</kwd><kwd>salivary glands</kwd><kwd>ultrasound examination</kwd><kwd>hyperprolactinemia</kwd><kwd>IGF-1</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пржиялковская Е.Г., Мокрышева Н.Г., Трошина Е.А., Мельниченко Г.А., Дедов И.И., Анциферов М.Б., Астафьева Л.И., Бардымова Т.П., Белая Ж.Е., Вагапова Г.Р., Воротникова С.Ю., Григорьев А.Ю., Гринева Е.Н., Дзеранова Л.К., Иловайская И.А., Калинин П.Л., Лапшина А.М., Луценко А.С., Мамедова Е.О., Марова Е.И., Перепелова М.А., Пигарова Е.А., Пронин В.С., Рожинская Л.Я., Трунин Ю.Ю., Шутова А.С. 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