medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-34-21-27medalphabet-4844Research ArticleСтатьиВзаимосвязь экзокринной и эндокринной функций поджелудочной железы в норме и при патологииThe interrelationship between the exocrine and endocrine functions of the pancreas in health and diseasehttps://orcid.org/0009-0004-7320-8934ЕвсиковА. Е.EvsikovA. E.

Евсиков Александр Евгеньевич, к. м. н., доцент кафедры гастроэнтерологии

Москва

Evsikov Aleksandr E., PhD Med, associate professor at Dept of Gastroenterology

Moscow

peachfx@ya.ruhttps://orcid.org/0000-0002-7723-7992МинушкинО. Н.MinushkinO. N.

Минушкин Олег Николаевич, д. м. н., профессор, заведующий кафедрой гастроэнтерологии

Москва

Minushkin Oleg N., Dr Med Sci (habil.), professor, head of Dept of Gastroenterology

Moscow

oleg.minushkin@bk.ruhttps://orcid.org/0000-0001-6210-8955ЗверковИ. В.ZverkovI. V.

Зверков Игорь Владимирович, д. м. н., профессор кафедры гастроэнтерологии

Москва

Zverkov Igor V., Dr Med Sci (habil.), professor at Dept of Gastroenterology

Moscow

prof.igor.zverkov@mail.ruhttps://orcid.org/0000-0002-5111-8127МасловскийЛ. В.MaslovskyL. V.

Масловский Леонид Витальевич, д. м. н., доцент кафедры гастроэнтерологии

Москва

Maslovsky Leonid V., Dr Med Sci (habil.), associate professor at Dept of Gastroenterology

Moscow

lemas3@yandex.ruФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of the Russian FederationRussian Federation202527012026134«Гастроэнтерология и диетология» (4)2127Copyright © Евсиков А.Е., Минушкин О.Н., Зверков И.В., Масловский Л.В., 20262026Евсиков А.Е., Минушкин О.Н., Зверков И.В., Масловский Л.В.Evsikov A.E., Minushkin O.N., Zverkov I.V., Maslovsky L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4844

В статье рассматриваются теоретические аспекты взаимодействия экзокринной и эндокринной частей поджелудочной железы (ПЖ), а также различные патологии, иллюстрирующие эти процессы. К освещаемым заболеваниям относятся хронический панкреатит (ХП), острый панкреатит (ОП), сахарный диабет (СД), стеатоз ПЖ и некоторые другие. Приведены данные о распространенности СД при различных патологиях ПЖ и о частоте развития экзокринной недостаточности ПЖ (ЭНПЖ) при СД. Представлены факторы риска СД при панкреатической патологии. Обсуждаются механизмы патогенеза упомянутых состояний, рассматриваемые положения подкреплены экспериментальными данными. Кроме того, обсуждаются некоторые потенциальные методы терапевтического воздействия, которые могут повысить эффективность лечения при указанных состояниях.

This article examines the theoretical aspects of the interaction between the exocrine and endocrine parts of the pancreas (P), as well as various pathologies illustrating these processes. The diseases covered include chronic pancreatitis (CP), acute pancreatitis (AP), diabetes mellitus (DM), pancreatic steatosis, and several others. Data on the prevalence of DM in various pancreatic pathologies and the incidence of exocrine pancreatic insufficiency (EPI) in DM are provided. Risk factors for DM in pancreatic pathology are presented. The mechanisms of pathogenesis of these conditions are discussed, and the presented concepts are supported by experimental data. Additionally, several potential therapeutic interventions that may improve treatment efficacy in these conditions are discussed.

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The authors declare that there are no conflicts of interest present.