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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2025-35-27-33</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4769</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Ишемия миокарда без обструкции коронарных артерий (INOCA). Часть II. Клинико-инструментальные особенности патологии</article-title><trans-title-group xml:lang="en"><trans-title>Myocardial ischemia with nonobstructive coronary arteries (INOCA). Part II. Clinical and instrumental features of the pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-8861-8221</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мовсисян</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Movsisyan</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мовсисян Давид Маисович, младший научный сотрудник отделения неотложной клинической кардиологии с методами неинвазивной функциональной диагностики</p></bio><bio xml:lang="en"><p>Movsisyan David M., junior researcher at Dept of Emergency Clinical Cardiology with Non-invasive Functional Diagnostics</p></bio><email xlink:type="simple">davidmovsisyan1112@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-8752-1128</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комиссаров</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Komissarov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Комиссаров Евгений Александрович, клинический ординатор</p></bio><bio xml:lang="en"><p>Komissarov Evgeny A., clinical resident</p></bio><email xlink:type="simple">jkumys@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-4371-1203</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурцева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Burtseva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бурцева Нина Владимировна, младший научный сотрудник отделения неотложной клинической кардиологии с методами неинвазивной функциональной диагностики</p></bio><bio xml:lang="en"><p>Burtseva Nina V., junior researcher at Dept of Emergency Clinical Cardiology with Non-invasive Functional Diagnostics</p></bio><email xlink:type="simple">nina.artuxowa@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6229-8629</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиджанова</surname><given-names>Х. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Alidzhanova</surname><given-names>Kh. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиджанова Хафиза Гафуровна, д.м.н., старший преподаватель учебного центра, старший научный сотрудник отделения неотложной кардиологии с методами неинвазивной диагностики</p></bio><bio xml:lang="en"><p>Alidzhanova Khafiza G., Dr Med Sci (habil.), senior lecturer at Training Center, senior researcher at Dept of Emergency Cardiology with Non-invasive Diagnostics</p></bio><email xlink:type="simple">alidzhanovahg@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2025</year></pub-date><volume>0</volume><issue>35</issue><issue-title>Кардиология. Неотложная медицина (4)</issue-title><fpage>27</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мовсисян Д.М., Комиссаров Е.А., Бурцева Н.В., Алиджанова Х.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Мовсисян Д.М., Комиссаров Е.А., Бурцева Н.В., Алиджанова Х.Г.</copyright-holder><copyright-holder xml:lang="en">Movsisyan D.M., Komissarov E.A., Burtseva N.V., Alidzhanova K.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4769">https://www.med-alphabet.com/jour/article/view/4769</self-uri><abstract><p>Вопросы диагностики, ведения и лечения больных с ишемией без обструкции коронарных артерий (INOCA) остаются до конца не решенными, особенно в условиях реальной клинической практики. Целью ретроспективного наблюдательного исследования был анализ клиникоинструментальных особенностей пациентов с INOCA, с попыткой выделить наиболее вероятные патогенетические варианты заболевания для дальнейшей высокотехнологичной диагностики и разработки индивидуальной тактики лечения. Проанализированы 52 истории болезни пациентов с INOCA, госпитализированных в НИИ СП им. Н.В. Склифосовского с диагнозом «острый коронарный синдром без подъема сегмента ST», у которых по данным коронарографии (КАГ) не было выявлено стенозов коронарных артерий (КА) либо сужения были менее 50%. По данным КАГ, у 41 пациента (78,8%) выявлены аномалии КА (мышечный миокардиальный мостик, патологическая извитость, замедление пассажа контраста, спазм). Перенесенный ранее инфаркт миокарда диагностирован у 42,3% больных. Пациенты распределены по предполагаемым эндотипам INOCA, среди которых чаще встречался вазоспастический вариант. В условиях кардиологического стационара врачу необходимо своевременно и в полном объеме оценить клинико-инструментальную характеристику пациента с INOCA для определения показаний к проведению специализированной внутрикоронарной диагностики, атакже назначению оптимальной комплексной терапии, включая рентгенэндоваскулярные и хирургические методы.</p></abstract><trans-abstract xml:lang="en"><p>The diagnosis, management, and treatment issues of ischemia with nonobstructive coronary arteries (INOCA) patients remain unresolved, especially in “real-life” clinical practice settings. The goal of this retrospective observational study was to analyze the clinical and instrumental features of INOCA patients. An attempt was made to identify the most likely pathogenetic variants of the disease for further high-tech diagnostics and treatment strategy optimization. We analyzed 52 medical records of patients with INOCA hospitalized at the N.V. Sklifosovsky Research Institute for Emergency Medicine with a diagnosis of «acute coronary syndrome without ST-segment elevation.» Coronary angiography revealed no coronary artery stenosis or stenosis less than 50%. According to coronary angiography 41 patients (78.8%) had coronary artery anomalies (muscular myocardial bridge, pathological coronary tortuosity, coronary slow flow phenomenon and spasm). Old myocardial infarction was diagnosed in 42.3% of patients. Patients were classified according to presumed INOCA endotypes, with the vasospastic variant being the most common. In a cardiology department physicians should promptly and comprehensively assess the patient’s clinical and instrumental characteristics to determine indications for intracoronary diagnostics and to prescribe optimal therapy, including endovascular and surgical techniques. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>INOCA</kwd><kwd>микрососудистая стенокардия</kwd><kwd>вазоспастическая стенокардия</kwd><kwd>мышечный миокардиальный мостик</kwd><kwd>патологическая извитость коронарных артерий</kwd><kwd>замедление пассажа контрастного вещества</kwd></kwd-group><kwd-group xml:lang="en"><kwd>INOCA</kwd><kwd>microvascular angina</kwd><kwd>vasospastic angina</kwd><kwd>muscular myocardial bridge</kwd><kwd>coronary arteries tortuosity</kwd><kwd>coronary slow flow phenomenon</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shah SM, Tremmel JA, Henry TD, Smilowitz NR, Prasad M, Kobayashi Y, Henry GA, Samady H, Samuels BA, Lerman A, Moses JW, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky AJ. 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