medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-36-61-65medalphabet-4715Research ArticleСтатьиРоль генетической предрасположенности в регуляции половыми гормонами агрессивного поведенияThe role of genetic predisposition in the regulation of aggressive behavior by sex hormoneshttps://orcid.org/0000-0002-4293-3285ОрловаН. В.OrlovaN. V.

Орлова Наталья Васильевна, д. м. н., проф., проф. кафедры факультетской терапии Института материнства и детства, ведущий научный сотрудник лаборатории

Москва

Тюмень

Orlova Natalia V., DM Sci (habil.), prof. at Dept of Faculty Therapy of Institute of Motherhood and Childhood, Leading Researcher at the laboratory

Moscow

Tyumen

vrach315@yandex.ruhttps://orcid.org/0000-0001-8452-5522СуворовГ. Н.SuvorovG. N.

Суворов Георгий Николаевич, к. ю. н., начальник управления научной и инновационной работы, заведующий лабораторией

Тюмень

Suvorov Georgy N., PhD Law, head of Dept of Scientific and Innovative Work, head of the Laboratory

Tyumen

ipk6019086@yandex.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России (Пироговский университет); ФГАОУ ВО «Тюменский государственный университет»РоссияN. I. Pirogov Russian National Research Medical University (Pirogov University); Tyumen State UniversityRussian FederationФГАОУ ВО «Тюменский государственный университет»РоссияTyumen State UniversityRussian Federation202502122025036«Современная поликлиника» (2)6165Copyright © Орлова Н.В., Суворов Г.Н., 20252025Орлова Н.В., Суворов Г.Н.Orlova N.V., Suvorov G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4715

В уголовной практике защита может основываться на доказательстве невменяемости обвиняемого. Предрасположенность к преступному поведению может быть генетически обусловленной. Антисоциальное расстройство личности имеет гендерные особенности. Изучение влияния половых гормонов на склонность индивидов к антисоциальному и агрессивному поведению выявило роль генов, кодирующих тестостерон и эстрогены, генов семейства цитохрома, участвующих в синтезе стероидных гормонов. Значительно менее изученной является взаимосвязь с агрессией генов лютеинизирующего и фолликулостимулирующего гормона. В исследованиях получена связь пролактина с агрессией на фоне употребления наркотических веществ. Данные исследований выявили роль генов окситоцина в агрессивном поведении детей. Эпидемиологические исследования свидетельствуют о важной роли в импульсивном агрессивном поведении Y-хромосомы. Однако полученные результаты по взаимосвязи агрессивных черт личности с генами, регулирующими половые гормоны, неоднозначны. Одной из причин противоречивости результатов исследований может являться ограниченная выборка по численности испытуемых. Сложность регуляции поведения требует моделей, учитывающих множество маркеров.

In criminal practice, the defense may be based on proof of the defendant’s insanity. Predisposition to criminal behavior may be genetically determined. Antisocial personality disorder has gender characteristics. The study of the effect of sex hormones on the propensity of individuals to antisocial and aggressive behavior revealed the role of genes encoding testosterone and estrogens, cytochrome family genes involved in the synthesis of steroid hormones. The relationship with the aggression of luteinizing and follicle-stimulating hormone genes is much less studied. In studies, the relationship of prolactin with aggression against the background of drug use was obtained. The research data revealed the role of oxytocin genes in aggressive behavior of children. Epidemiological studies indicate an important role in the impulsive aggressive behavior of the Y chromosome. However, the results obtained on the relationship of aggressive personality traits with genes regulating sex hormones are ambiguous. One of the reasons for the inconsistency of the research results may be a limited sample of the number of subjects. The complexity of regulating behavior requires models that take into account many markers.

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The authors declare that there are no conflicts of interest present.