medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-23-80-85medalphabet-4664Research ArticleСтатьиАктуальные возможности профилактики развития и выраженности поствоспалительной гиперпигментации при лечении больных с акнеCurrent possibilities for the prevention and severity of post‑inflammatory hyperpigmentation development in the treatment of patients with acnehttps://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., профессор, заведующая кафедрой дерматовенерологии и косметологии, проректор по учебной работе

Москва

Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, vice‑rector for Academic Affairs 

Moscow 

kruglovals@mail.ruhttps://orcid.org/0000-0003-4920-5288ОльховскаяК. Б.OlkhovskayaK. B.

Ольховская Кира Брониславовна, к.м.н., доцент кафедры дерматовенерологии и косметологии

Москва

Olkhovskaya Kira B., PhD Med, associate professor at Dept of Dermatovenereology and Cosmetology

Moscow

olhovskaya_kira@mail.ruФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of the Russian FederationRussian Federation202511112025123Дерматология (2)8085Copyright © Круглова Л.С., Ольховская К.Б., 20252025Круглова Л.С., Ольховская К.Б.Kruglova L.S., Olkhovskaya K.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4664

Акнеиндуцированная поствоспалительная гиперпигментация является частым последствием развития акне, которая способствует неудовлетворенности пациентов результатами терапии. Патофизиология данного вида дисхромии представляет собой сложную совокупность взаимодействия изменения клеточных структур кожи, нарушений функционирования различных сигнальных путей и иммунного ответа, индуцированного деятельностью бактериальной биоты. Ретиноиды являются неотъемлемыми средствами лекарственной терапии акне, которые также активно используются для профилактики и лечения различного рода состояний, сопровождающихся усиленным меланогенезом. Трифаротен – селективный в отношении RARγ ретиноид 4‑го поколения. Проведенное исследование IV фазы LEAP (AkLief Evaluation in Acne‑induced Post‑inflammatory hyperpigmentation) показало, что трифаротен способствует активному снижению выраженности пигментации кожи с достижением значимого клинического эффекта в отношении проявлений акне. Современные научные достижения позволяют идти по пути своевременного предупреждения и устранения стойких косметических дефектов, развившиеся в результате акне.

Acne‑induced post‑inflammatory hyperpigmentation is a common consequence of acne development, which contributes to patient dissatisfaction with the results of therapy. The pathophysiology of this type of dyschromia is a complex set of interactions between changes in the cellular structures of the skin, disruptions in the functioning of various signaling pathways and the immune response induced by the activity of bacterial biota. Retinoids are integral means of drug therapy for acne, which are also actively used for the prevention and treatment of various conditions accompanied by increased melanogenesis. Trifarotene is a 4th generation retinoid selective for RARγ. The conducted phase IV study LEAP (AkLief Evaluation in Acne‑induced Post‑inflammatory hyperpigmentation) showed that trifarotene contributes to an active decrease in the severity of skin pigmentation with the achievement of a significant clinical effect on acne manifestations. Modern scientific achievements make it possible to take the path of timely prevention and elimination of persistent cosmetic defects that develop as a result of acne.

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The authors declare that there are no conflicts of interest present.