medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-22-74-78medalphabet-4613Research ArticleСтатьиПерсонализированная коррекция микронутриентного статуса при гестационном сахарном диабете: от скрининга к терапииPersonalized correction of micronutrient status in gestational diabetes mellitus: from screening to therapyhttps://orcid.org/0000-0002-1736-9408ХабаровС. В.KhabarovS. V.

Хабаров Сергей Вячеславович, главный врач; д. м. н., профессор кафедры клинической лабораторной диагностики, медицинской микробиологии и патологической анатомии; профессор каф. «Акушерство и гинекология»

Москва

Тула

Khabarov Sergey V., chief physician; DM Sci (habil.), professor at Dept of Clinical Laboratory Diagnostics, Medical Microbiology and Pathological Anatomy; professor at Dept of Obstetrics and Gynecology

Moscow

Tula

s.v.habarov@mail.ruhttps://orcid.org/0000-0001-6052-9721НечайК. О.NechayK. O.

Нечай Ксения Олеговна, аспирант кафедры клинической лабораторной диагностики, медицинской микробиологии и патологической анатомии

Москва

Nechay Ksenia O., postgraduate student at Dept of Clinical Laboratory Diagnostics, Medical Microbiology and Pathological Anatomy

Moscow

xenya.ne4ay2016@yandex.ruГруппа медицинских компаний «Медма», Сеть клиник репродуктивного здоровья «Геном», ООО «ВИТРОМЕД», Клиника ВитроКлиник; Академия постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства» (Академия постдипломного образования ФГБУ ФНКЦ ФМБА; ФГБОУ ВО «Тульский государственный университет», Медицинский институт России)РоссияMedma Medical Group, Genom Reproductive Health Clinic Network, VITROMED LLC, VitroClinic Clinic; Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia; Tula State University, Medical InstituteRussian FederationАкадемия постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства» (Академия постдипломного образования ФГБУ ФНКЦ ФМБА России)РоссияAcademy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency of RussiaRussian Federation202525102025022«Современная лаборатория» (2)7478Copyright © Хабаров С.В., Нечай К.О., 20252025Хабаров С.В., Нечай К.О.Khabarov S.V., Nechay K.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4613Актуальность

Актуальность. Низкий уровень витамина D, фолиевой кислоты, инозитола, в организме беременных женщин ассоциируется с наличием в анамнезе как акушерских и перинатальных осложнений, так и экстрагенитальных заболеваний. В последнее время все больше исследований направлено на поиск причинно-следственных связей между нарушением микронутриетного статуса в период гестации и признаками гестационного сахарного диабета.

Цель исследования

Цель исследования. Обзор литературы за последние 7 лет в международных (PubMed) и российских (eLIBRARY.RU) электронных библиотеках с целью изучения микронутриентного статуса у женщин с существующим гестационным сахарным диабетом в анамнезе и оценки влияния данного заболевания на беременность.

Материалы и методы исследования. Проанализированы научные базы данных PubMed и eLIBRARY.RU за период 2018–2025 годы. Было идентифицировано 107 работ, из которых 36 отобраны для анализа.

Результаты

Результаты. Полученные данные свидетельствуют о том, что прием женщинами с гестационным сахарным диабетом добавок с витамином D и инозитолом коррелировало с более благополучным протеканием беременности и успешным родоразрешением. Исследование влияния фолиевой кислоты на пациенток с этим заболеванием дало прямо противоположный результат.

Заключение

Заключение. Таким образом, существует необходимость внедрения систематического мониторинга микронутриентного статуса в прегравидарном периоде и на протяжении всей беременности для своевременной коррекции выявленных дефицитных состояний

Relevance

Relevance. Low levels of vitamin D, folic acid and inositol in pregnant women are associated with a history of both obstetric and perinatal complications, as well as extragenital diseases. Recently, an increasing number of studies have been focused on identifying cause-and-effect relationships between impaired micronutrient status during gestation and signs of gestational diabetes mellitus.

Objective

Objective. To review literature from the past 7 years in international (PubMed) and eLIBRARY.RU to study the micronutrient status in women with a history of gestational diabetes mellitus and to evaluate the impact of this condition on pregnancy.

Materials and Methods

Materials and Methods. Scientific databases PubMed and eLIBRARY.RU were analyzed for the period 2018–2025. A total of 107 publications were identified, of which 36 were selected for analysis.

Results

Results. The obtained data indicate that supplementation with vitamin D and inositol in women with gestational diabetes mellitus correlated with a more favorable course of pregnancy and successful delivery. The study of folic acid’s impact on patients with this condition yielded directly opposite results.

Conclusion

Conclusion. Therefore, there is a need to implement systematic monitoring of micronutrient status in the pregravid period and throughout pregnancy to ensure timely correction of identified deficiency states.

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The authors declare that there are no conflicts of interest present.