medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-22-8-13medalphabet-4601Research ArticleСтатьиКонцепция определения референтных интервалов на примере тиреоидной панелиThe concept of reference intervals using the thyroid panel as an examplehttps://orcid.org/0000-0003-2592-6857РойтманА. П.RoytmanA. P.

Ройтман Александр Польевич, д. м. н., профессор кафедры клинической лабораторной диагностики с курсом лабораторной иммунологи

Москва

Roytman Alexander P., DM Sci (habil.), professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology

Moscow

https://orcid.org/0009-0002-1063-9492КузнецоваТ. Е.KuznetsovaT. E.

Кузнецова Татьяна Евгеньевна, старший лаборант кафедры клинической лабораторной диагностики с курсом лабораторной иммунологии; врач клинической лабораторной диагностики

Москва

Kuznetsova Tatyana E., senior laboratory assistant at Dept of Clinical Laboratory Diagnostics with a Course of Laboratory Immunology; physician of clinical laboratory diagnostics

Moscow

kuznetsovate@bk.ruhttps://orcid.org/0000-0003-1404-4699БугровА. В.BugrovA. V.

Бугров Алексей Викторович, к. м. н., доцент кафедры клинической лабораторной диагностики с курсом лабораторной иммунологии

Москва

Bugrov Alexey V., PhD Med, associate professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology

Moscow

https://orcid.org/0000-0002-4945-7269ЕвгинаС. А.EvginaS. A.

Евгина Светлана Александровна, к. б. н., программный директор

Москва

Evgina Svetlana A., PhD Bio, program director

Moscow

https://orcid.org/0000-0002-9624-5883ШустовВ. В.ShustovV. V.

Шустов Валерий Валерьевич, заведующий клинической лаборатории Клиники имени профессора Ю. Н. Касаткина; врач клинической лабораторной диагностики 

Москва

Shustov Valery V., head of Clinical Laboratory of Yu. N. Kasatkin Clinic; physician of clinical laboratory diagnostics

Moscow

https://orcid.org/0009-0003-9534-2520ЛамбакахарМ. Г.LambakakharM. G.

Ламбакахар Мария Георгиевна, к. м. н., доцент кафедры клинической лабораторной диагностики с курсом лабораторной иммунологии

Москва

Lambakahar Maria G., PhD Med, associate professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology

Moscow

https://orcid.org/0000-0003-1537-7444ДолговВ. В.DolgovV. V.

Долгов Владимир Владимирович, д. м. н., профессор кафедры клинической лабораторной диагностики с курсом лабораторной иммунологии

Москва

Dolgov Vladimir V., DM Sci (habil.), professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology

Moscow

https://orcid.org/0000-0001-9612-6705ГодковМ. А.GodkovM. A.

Годков Михаил Андреевич, заведующий кафедрой клинической лабораторной диагностики с курсом лабораторной иммунологии; д. м. н., заведующий научным отделом лабораторной диагностики

Москва

Godkov Mikhail A., head of Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology; DM Sci (habil.), head of Scientific Dept of LaboratoryDiagnostics

Moscow

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ГБУЗ Научно-исследовательский институт скорой помощи имени Н. В. Склифосовского Департамента здравоохранения г. Москвы»РоссияRussian Medical Academy of Continuing Professional Education; N. V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationАссоциация «Федерация лабораторной медицины»РоссияAssociation of Laboratory Specialists and Organizations «Federation of Laboratory Medicine (FLM)Russian Federation202525102025022«Современная лаборатория» (2)813Copyright © Ройтман А.П., Кузнецова Т.Е., Бугров А.В., Евгина С.А., Шустов В.В., Ламбакахар М.Г., Долгов В.В., Годков М.А., 20252025Ройтман А.П., Кузнецова Т.Е., Бугров А.В., Евгина С.А., Шустов В.В., Ламбакахар М.Г., Долгов В.В., Годков М.А.Roytman A.P., Kuznetsova T.E., Bugrov A.V., Evgina S.A., Shustov V.V., Lambakakhar M.G., Dolgov V.V., Godkov M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4601

Обзор литературы посвящен обобщению имеющихся зарубежных и отечественных данных о новых подходах к оценке референтных интервалов (РИ) и обоснованию актуальности их применения в лабораторной практике. Обсуждаются преимущества и ограничения разных методов определения РИ. Приведен пример расчета РИ косвенным методом для тиреоидной панели наборами реагентов компании MINDRAY (Китай).

The review focuses on summarizing information about new approaches to the assessment of reference intervals (RI) and substantiating the relevance of their further application in clinical practice. The article considers the concept of RI using the thyroid panel as an example. The advantages and limitations of alternative methods for determining RI are discussed kits MINDRAY.

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The authors declare that there are no conflicts of interest present.