medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-21-55-59medalphabet-4596Research ArticleСтатьиРоль серотонинергической активности в импульсивной агрессии и противоправном поведенииThe role of serotonergic activity in impulsive aggression and illegal behaviorhttps://orcid.org/0000-0002-4293-3285ОрловаН. В.OrlovaN. V.

Орлова Наталья Васильевна, д. м. н., проф., проф. кафедры факультетской терапии Института материнства и детства; ведущий научный сотрудник лаборатории

Москва; Тюмень

Orlova Natalia V., DM Sci (habil.), professor at Dept of Faculty Therapy of Institute of Motherhood and Childhood; leading researcher at the laboratory

Moscow; Tyumen

vrach315@yandex.ruhttps://orcid.org/0000-0001-8452-5522СуворовГ. Н.SuvorovG. N.

Суворов Георгий Николаевич, к. ю. н., начальник управления научной и инновационной работы, заведующий лабораторией

Тюмень

Suvorov Georgy N., PhD Law, head of Dept of Scientific and Innovative Work, head of the laboratory

Tyumen

ipk6019086@yandex.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России (Пироговский университет); ФГАОУ ВО «Тюменский государственный университет»РоссияN. I. Pirogov Russian National Research Medical University (Pirogov University); Tyumen State UniversityRussian FederationФГАОУ ВО «Тюменский государственный университет»РоссияTyumen State UniversityRussian Federation202523102025021Неврология и психиатрия (3)5559Copyright © Орлова Н.В., Суворов Г.Н., 20252025Орлова Н.В., Суворов Г.Н.Orlova N.V., Suvorov G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4596

Импульсивная агрессия считается важным психопатологическим симптомом ряда психических расстройств, включая пограничные и антисоциальные расстройства личности. Серотонин играет критическую роль в модуляции настроения, тревоги, агрессии, цикла сна–бодрствования, мотивации, восприятия боли и нейроэндокринной функции, включая подавление агрессии. Выявлена корреляция тяжести агрессивного поведения с нейроэндокринными признаками низкой серотониновой функции. Серотонинергические гены играют важную роль в регуляции активности серотонина. В статье рассмотрены результаты проведенных исследований среди осужденных за насильственные и ненасильственные преступления. Изучена ассоциация различных генов, регулирующих активность серотонина, с агрессией. Дана характеристика нескольких серотонинергических генов-кандидатов риска развития антисоциального поведения, в основе которого находится импульсивная агрессия. В заключение делается вывод о противоречивости полученных результатов анализируемых исследований, обусловленной методологическими различиями, что требует дальнейшей разработки этой проблемы.

Impulsive aggression is considered an important psychopathological symptom of a number of mental disorders, including borderline and antisocial personality disorders. Serotonin plays a critical role in modulating mood, anxiety, aggression, sleep-wake cycle, motivation, pain perception and neuroendocrine function, including aggression suppression. The correlation of the severity of aggressive behavior with neuroendocrine signs of low serotonin function was revealed. Serotonergic genes play an important role in the regulation of serotonin activity. The article discusses the results of research conducted among those convicted of violent and nonviolent crimes. The association of various genes regulating serotonin activity with aggression has been studied. The characteristics of several serotonergic candidate genes for the risk of developing antisocial behavior, which is based on impulsive aggression, are given. In conclusion, the conclusion is made about the inconsistency of the results of the analyzed studies due to methodological differences, which requires further development of this problem.

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The authors declare that there are no conflicts of interest present.