medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-19-80-85medalphabet-4521Research ArticleСтатьиПробиотики и микробиота полости рта: проблемы и перспективыProbiotics and oral microbiota: problems and prospectshttps://orcid.org/0000-0002-3811-9459ПрокопенкоЕ. В.ProkopenkoE. V.

Прокопенко Елена Валерьевна, руководитель отдела развития и сопровождения МИС и сервисов департамента по развитию медицинской деятельности ООО «Инвитро»

Москва

Prokopenko Elena V., head of Dept for Development and Maintenance of MIS and Services of the Dept for Development of Medical Activities of Invitro LLC

Moscow

elvprokopenko@gmail.comhttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии, главный научный сотрудник

Москва

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology, Chief Researcher

Moscow

orlova-sv@rudn.ruhttps://orcid.org/0000-0003-4099-2967ПодопригораИ. В.PodoprigoraI. V.

Подопригора Ирина Викторовна, к.м.н., доцент, зав. кафедрой микробиологии им. В.С. Киктенко медицинского факультета

Москва

Podoprigora Irina V., PhD Med, associate professor, head of Dept of Microbiology 

Moscow

podoprigora-iv@rudn.ruhttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaE. A.

Никитина Елена Александровна, к.м.н., доцент кафедры диетологии и клинической нутрициологии, научный сотрудник3, эксперт Методического аккредитационно-симуляционного центра

Москва

Nikitina Elena A., PhD Med, associate professor at Dept of Dietetics and Clinical Nutrition, Research Fellow, Expert of the Methodological Accreditation and Simulation Center

Moscow

nikitina-ea1@rudn.ruhttps://orcid.org/0000-0003-1820-7862ГеворкянА. А.GevorkyanA. A.

Геворкян Алексей Альбертович, к.м.н., доцент, доцент кафедры терапевтической стоматологии

Москва

Gevorkyan Alexey A., PhD Med associate professor at Dept of Therapeutic Dentistry

Moscow

alexeygevorkyan@mail.ruhttps://orcid.org/0009-0004-1157-8622ОрловаА. А.OrlovaA. A.

Орлова Анастасия Алексеевна, студентка Медицинского института 

Москва

Orlova Anastasia A., student at Institute of Medicine 

Moscow

1032202909@rudn.ruhttps://orcid.org/0009-0001-3424-6485АйдынЭ. Э.AydinE. E.

Айдын Эмрие Эрденовна, студентка Медицинского института 

Москва

Aydin Emriye E., student at Institute of Medicine 

Moscow

emma.aydin@mail.ruООО «ИНВИТРО»РоссияINVITRO LLCRussian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba (RUDN) ; Scientific and Practical Center for Child Psychoneurology of the Moscow City Health DepartmentRussian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН)РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba (RUDN)Russian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы» ; ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава РоссииРоссияPeoples’ Friendship University of Russia named after Patrice Lumumba (RUDN) ; Scientific and Practical Center for Child Psychoneurology of the Moscow City Health Department ; National Medical Research Center for Therapy and Preventive Medicine of the Russian Ministry of HealthRussian Federation202530082025119«Диетология и нутрициология»8085Copyright © Прокопенко Е.В., Орлова С.В., Подопригора И.В., Никитина Е.А., Геворкян А.А., Орлова А.А., Айдын Э.Э., 20252025Прокопенко Е.В., Орлова С.В., Подопригора И.В., Никитина Е.А., Геворкян А.А., Орлова А.А., Айдын Э.Э.Prokopenko E.V., Orlova S.V., Podoprigora I.V., Nikitina E.A., Gevorkyan A.A., Orlova A.A., Aydin E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4521

Микробиом полости рта представляет собой сложную экосистему, которая играет ключевую роль в поддержании здоровья полости рта и всего организма. Дисбиоз способствует возникновению таких распространенных заболеваний, как кариес, заболевания пародонта, галитоз, и может изменять течение и патогенез ряда системных заболеваний. Пробиотики стали перспективной терапевтической и профилактической стратегией, оказывая свое действие через различные механизмы. Клинические исследования и метаанализы свидетельствуют о потенциальной пользе ряда пробиотических штаммов, однако эффективность применения пробиотиков зависит от конкретного штамма, дозировки, длительности применения и других факторов.

The oral microbiome is a complex ecosystem that plays a key role in maintaining oral and overall health. Dysbiosis contributes to the development of common diseases such as dental caries, periodontal disease, halitosis, and can alter the course and pathogenesis of a number of systemic diseases. Probiotics have become a promising therapeutic and preventive strategy, exerting their effect through various mechanisms. Clinical studies and meta-analyses indicate the potential benefit of a number of probiotic strains, but the effectiveness of probiotics depends on the specific strain, dosage, duration of use, and other factors.

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The authors declare that there are no conflicts of interest present.