medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-19-60-70medalphabet-4519Research ArticleСтатьиНедифференцированная дисплазия соединительной ткани и кожа: что делать? Позиция диетологаUndifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s positionhttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaE. A.

Никитина Елена Александровна, к.м.н., доцент кафедры диетологии и клинической нутрициологии, научный сотрудник, эксперт Методического аккредитационно-симуляционного центра

Москва 

Nikitina Elena A., PhD Med, associate professor at Dept of Dietetics and Clinical Nutrition, research fellow2, expert of Methodological Accreditation and Simulation Center

nikitina-ea1@rudn.ruhttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии, главный научный сотрудник

Москва 

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology, Chief Researcher

rudn_nutr@mail.ruhttps://orcid.org/0000-0003-0928-2131БатышеваТ. Т.BatyshevaT. T.

Батышева Татьяна Тимофеевна, д.м.н., проф., заслуженный врач РФ, зав. кафедрой неврологии, физической, реабилитационной медицины и психологии детского возраста, директор, гл. внештатный детский специалист невролог ДЗМ, гл. внештатный детский специалист по медицинской реабилитации Минздрава России

Москва 

Batysheva Tatyana T., DM Sci (habil.), professor, Honored Doctor of the Russian Federation, head of Dept of Neurology, Physical, Rehabilitation Medicine and Childhood Psychology, director, chief freelance pediatric neurologist of the Moscow Health Department, chief freelance pediatric specialist in medical rehabilitation of the Russian Ministry of Health

https://orcid.org/0000-0002-0548-3414БалашоваН. В.BalashovaN. V.

Балашова Наталья Валерьевна, к.б.н., доцент кафедры диетологии и клинической нутрициологии, доцент кафедры клинической лабораторной диагностики факультета усовершенствования врачей

Author ID: 832745

Москва

Balashova Natalya V., PhD Bio, assistant professor at Dept of Dietetics and Clinical Nutritiology, assistant professor at Dept of Clinical Laboratory Diagnostics of the Faculty of Advanced Training of Doctors

Author ID: 832745

BalashovaN77@mail.ruhttps://orcid.org/0000-0001-8448-8493АлексееваМ. В.AlekseevaM. V.

Алексеева Марина Валерьевна, к.м.н., зам. директора по организационно-методической работе

Москва

Alekseeva Marina.V., Ph.D., Deputy Director for Organizational and Methodological Work

BalashovaN77@mail.ruФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы» ; ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава РоссииRussian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»Russian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского»Russian FederationГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»Russian Federation202530082025119«Диетология и нутрициология»6071Copyright © Никитина Е.А., Орлова С.В., Батышева Т.Т., Балашова Н.В., Алексеева М.В., 20252025Никитина Е.А., Орлова С.В., Батышева Т.Т., Балашова Н.В., Алексеева М.В.Nikitina E.A., Orlova S.V., Batysheva T.T., Balashova N.V., Alekseeva M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4519

Недифференцированная дисплазия соединительной ткани (НДСТ) является частым скрытым диагнозом наприеме у косметолога и дерматолога, который может влиять на прогноз, выбор процедуры и тактику ведения пациента. Будучи генетически обусловленным нарушением формирования соединительной ткани и проявляющееся полиморфными изменениями со стороны кожи, суставов, сосудов и внутренних органов, НДСТ не имеет четких диагностических критериев, что затрудняет своевременную диагностику. Особую проблему представляют преждевременное старение, которое у пациентов с НДСТ опережает биологический возраст в среднем на 8 лет, и нарушение полноценной репарации тканей на фоне НДСТ. Эти изменения обусловлены нарушением синтеза коллагена, эластина и гликозаминогликанов. Поскольку НДСТ является генетической патологией, ее невозможно полностью устранить, однако комплексный подход, включающий диетотерапию и коррекцию микронутриентных дефицитов, позволяет замедлить прогрессирование диспластических изменений и улучшить репаративные процессы после аппаратных и инъекционных косметологических процедур. В данном обзоре рассмотрены ключевые нутриенты, влияющие на метаболизм соединительной ткани, а также современные данные об эффективности диетотерапии и БАД при НДСТ.

Undifferentiated connective tissue dysplasia (UCTD) is a common hidden diagnosis at a cosmetologist and dermatologist appointment, which can affect the prognosis, choice of procedure and patient management tactics. Being a genetically determined disorder of connective tissue formation and manifested by polymorphic changes in the skin, joints, blood vessels and internal organs, UCTD has no clear diagnostic criteria, which complicates timely diagnostics. A particular problem is premature aging, which in patients with UCTD is ahead of biological age by an average of 8 years, and impaired full tissue reparation against the background of UCTD. These changes are due to impaired synthesis of collagen, elastin and glycosaminoglycans. Since UCTD is a genetic pathology, it cannot be completely eliminated, but an integrated approach, including diet therapy and correction of micronutrient deficiencies, can slow down the progression of dysplastic changes and improve reparative processes after hardware-based and injectable cosmetology procedures. This review examines key nutrients that affect connective tissue metabolism, as well as current data on the effectiveness of diet therapy and dietary supplements for UCTD.

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The authors declare that there are no conflicts of interest present.