medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/20785631202517913medalphabet-4507Research ArticleСтатьиНативный коллаген II типа при заболеваниях опорно-двигательного аппарата: практика и перспективы примененияNative type II collagen in musculoskeletal disorders: current practice and future directionshttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaE.  A.

Никитина Елена Александровна, к.м.н., доцент кафедры диетологии и клинической нутрициологии; научный сотрудник; эксперт Методического аккредитационно-симуляционного центра

Москва

Nikitina Elena A., PhD Med, associate professor at Dept of Dietetics and Clinical Nutrition; research fellow; Expert of the Methodological Accreditation and Simulation Center

Moscow

nikitina-ea1@rudn.ruhttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии; главный научный сотрудник

Москва

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology; chief researcher

Moscow

orlova-sv@rudn.ruhttps://orcid.org/0000-0003-0928-2131БатышеваТ.  Т. BatyshevaT.  T.

Батышева Татьяна Тимофеевна, д.м.н., проф., заслуженный врач РФ, директор; глав. внештатный детский специалист невролог ДЗМ, гл. внештатный детский специалист по медицинской реабилитации Минздрава России, зав. кафедрой неврологии, физической, реабилитационной медицины и психологии детского возраста

Москва

Batysheva Tatyana T., DM Sci (habil.), professor, director; head. freelance pediatric specialist neurologist of the Dept of Healthcare, chief freelance children’s specialist in medical rehabilitation of the Russian Ministry of Health, head of Dept of Neurology, Physical, Rehabilitation Medicine and Childhood Psychology; Honored Doctor of the Russian Federation

Moscow

https://orcid.org/0000-0002-0548-3414БалашоваН. В.BalashovaN. V.

Балашова Наталья Валерьевна, к.б.н., доцент кафедры диетологии и клинической нутрициологии; доцент кафедры клинической лабораторной диагностики факультета усовершенствования врачей

Москва

Author ID: 832745

Balashova Natalya V., PhD Bio, assistant professor at Dept of Clinical Laboratory Diagnostics of the Faculty of Advanced Training of Doctors; assistant professor at Dept of Dietetics and Clinical Nutritiology

Moscow

Author ID: 832745

BalashovaN77@mail.ruhttps://orcid.org/0000-0001-8448-8493АлексееваМ. В.AlekseevaM. V.

Алексеева Марина Валерьевна, к.м.н., зам. директора по организационно-методической работе

Москва

Alekseeva Marina.V., PhD Med, deputy director for Organizational and Methodological Work

Moscow

ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН); ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»; ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава РоссииРоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Health; National Medical Research Center for Therapy and Preventive MedicineRussian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН); ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of HealthRussian FederationФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН); ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; M. F. Vladimirskii Moscow Regional Scientific Research Institute (MONIKI)Russian FederationГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»РоссияScientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of HealthRussian Federation202530082025017«Современная поликлиника» (1)913Copyright © Никитина Е.А., Орлова С.В., Батышева Т.Т., Балашова Н.В., Алексеева М.В., 20252025Никитина Е.А., Орлова С.В., Батышева Т.Т., Балашова Н.В., Алексеева М.В.Nikitina E.A., Orlova S.V., Batysheva T.T., Balashova N.V., Alekseeva M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4507

Коллаген – основной структурный белок соединительной ткани, составляющий более четверти всех белков организма. Из 29 известных типов коллагена особое значение имеет коллаген II типа, формирующий основу суставного хряща. В отличие от гидролизованных форм, нативный коллаген II типа (НК-II) сохраняет исходную химическую структуру, что позволяет ему выступать в качестве индуктора оральной толерантности. Клинические исследования демонстрируют эффективность НК-II в уменьшении воспаления, боли и улучшении функции суставов при остеоартрозе и ревматоидном артрите. Перспективным направлением является разработка препаратов на основе коллагена морских животных сулучшенным профилем безопасности. Необходимы масштабные исследования для оптимизации режимов испособов применения.

Collagen is a primary structural protein of connective tissue, accounting for over a quarter of all body proteins. Among 29 known collagen types, type II collagen is particularly significant as it forms the foundation of articular cartilage. Unlike hydrolyzed forms, native type II collagen (UC–II) maintains its original chemical structure, enabling it to function as an oral tolerance inducer. Clinical studies demonstrate effectiveness of UC–II in reducing inflammation, alleviating pain, and improving joint function in osteoarthritis and rheumatoid arthritis. A promising development direction involves marinederived collagen preparations with enhanced safety profiles. Large-scale studies are needed to optimize dosage regimens and administration methods.

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The authors declare that there are no conflicts of interest present.