medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-16-64-67medalphabet-4490Research ArticleСтатьиАспекты иммунного ответа при инфекции, вызванной вирусом Западного НилаAspects of the immune response in West Nile virus infectionhttps://orcid.org/0009-0005-5123-2076ИстинА. А.IstinA. A.

Истин Александр Александрович, ординатор кафедры инфекционных болезней и клинической иммунологии

Воронеж

Istin Alexander A., resident at Dept of Infectious Diseases and Clinical Immunology

Voronezh

istin2013@yandex.ruhttps://orcid.org/0000-0003-4796-7334КрасноруцкаяО. Н.KrasnorutskayaO. N.

Красноруцкая Ольга Николаевна, д.м.н., доцент, заведующая кафедрой инфекционных болезней и клинической иммунологии

Воронеж

AuthorID: 727938

Krasnorutskaya Olga N., DM Sci (habil.), associate professor, head of Dept of Infectious Diseases and Clinical Immunology

Voronezh

AuthorID: 727938

БезлепкинА. С.BezlepkinA. S.

Безлепкин Антон Сергеевич, ординатор кафедры инфекционных болезней и клинической иммунологии

Воронеж

Bezlepkin Anton S., resident at Dept of Infectious Diseases and Clinical Immunology

Voronezh

https://orcid.org/0000-0002-1707-436XШевцоваВ. И.ShevtsovaV. I.

Шевцова Вероника Ивановна, к.м.н., доцент кафедры инфекционных болезней и клинической иммунологии

Воронеж

Shevtsova Veronika I., PhD Med, associate professor at Dept of Infectious Diseases and Clinical Immunology

Voronezh

СаломахинГ. Г.SalomakhinG. G.

Саломахин Георгий Георгиевич, к.м.н., доцент кафедры инфекционных болезней и клинической иммунологии

Воронеж

AuthorID: 690475

Salomakhin Georgy G., PhD Med, associate professor at Dept of Infectious Diseases and Clinical Immunology

Voronezh

AuthorID: 690475

ФГБОУ ВО «Воронежский государственный медицинский университет имени Н.Н. Бурденко» Минздрава РоссииРоссияVoronezh State Medical University named after N.N. BurdenkoRussian Federation202529072025016Эпидемиология, гигиена, инфекционные болезни (1)6467Copyright © Истин А.А., Красноруцкая О.Н., Безлепкин А.С., Шевцова В.И., Саломахин Г.Г., 20252025Истин А.А., Красноруцкая О.Н., Безлепкин А.С., Шевцова В.И., Саломахин Г.Г.Istin A.A., Krasnorutskaya O.N., Bezlepkin A.S., Shevtsova V.I., Salomakhin G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4490

Лихорадка Западного Нила (ЛЗН) – это зоонозная инфекция, вызванная вирусом Западного Нила (WNV), который относится к семейству Flaviviridae и роду Flavivirus. Вирус передаётся человеку через укусы инфицированных комаров, чаще всего из рода Culex. Актуальность данной инфекции остается на высоком уровне из-за распространения по миру и поражения центральной нервной системы. Также не разработаны методы специфической диагностики и лечения данного заболевания. Исследование иммунной системы может помочь в решении этих проблем. Иммунный ответ на вирус Лихорадки Западного Нила представляет собой сложное взаимодействие врождённых и адаптивных механизмов. В то время как иммунная система обычно эффективно контролирует инфекцию, в некоторых случаях чрезмерное воспаление или недостаточный иммунный ответ могут приводить к тяжёлым последствиям, включая поражение ЦНС. Понимание этих механизмов имеет ключевое значение для разработки вакцин и терапевтических подходов к лечению ЛЗН.

West Nile fever (WNF) is a zoonotic infection caused by West Nile virus (WNV), which belongs to the family Flaviviridae and the genus Flavivirus. The virus is transmitted to humans through the bites of infected mosquitoes, most often from the genus Culex. The relevance of this infection remains at a high level due to its worldwide spread and damage to the central nervous system. Also, methods of specific diagnosis and treatment of this disease have not been developed. Research on the immune system can help solve these problems. The immune response to West Nile virus is a complex interaction of innate and adaptive mechanisms. While the immune system usually effectively controls infection, in some cases excessive inflammation or an insufficient immune response can lead to severe consequences, including damage to the central nervous system. Understanding these mechanisms is of key importance for the development of vaccines and therapeutic approaches to the treatment of WNF.

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The authors declare that there are no conflicts of interest present.