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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2025-11-25-32</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4423</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Хирургическое лечение больных мелкоклеточным раком легкого</article-title><trans-title-group xml:lang="en"><trans-title>Surgery in the treatment of small cell lung cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7441-9846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксарин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksarin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аксарин Алексей Александрович - д.м.н., доцент кафедры хирургических болезней Сургутский государственный университет, руководитель окружного онкологического центра Сургутская окружная клиническая больница.</p><p>Сургут</p></bio><bio xml:lang="en"><p>Aksarin Aleksei A. - DM Sci (habil.), associate professor at Dept of Surgical Diseases Surgut State University, head of the Oncology Center Surgut Regional Clinical Hospital.</p><p>Surgut</p></bio><email xlink:type="simple">alexaa1971@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7335-895X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тер-Ованесов</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ter-Ovanesov</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тер-Ованесов Михаил Дмитриевич - д.м.н., проф., зав. кафедрой онкологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Ter-Ovanesov Michail D. - DM Sci (habil.), prof., head of Dept of Oncology.</p><p>Moscow</p></bio><email xlink:type="simple">termed@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2450-8516</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Копейка</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kopeyka</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Копейка Сергей Михайлович - зав. онкологическим отделением абдоминальной и торакальной онкологии.</p><p>Сургут</p></bio><bio xml:lang="en"><p>Kopeyka Sergei M. – head of Dept Abdominal and Thoracic Oncology.</p><p>Surgut</p></bio><email xlink:type="simple">KopeykaSM@surgutokb.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1867-3655</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волкивский</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Volkivskiy</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волкивский Александр Борисович - врач-онколог онкологического отделения абдоминальной и торакальной онкологии.</p><p>Сургут</p></bio><bio xml:lang="en"><p>Volkivskiy Alexandr B. - oncologist at Dept Abdominal and Thoracic Oncology.</p><p>Surgut</p></bio><email xlink:type="simple">volkivskiiab@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивахненко</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivakhnenko</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивахненко Игорь Анатольевич - заместитель руководителя по медицинской части.</p><p>Нижневартовск</p></bio><bio xml:lang="en"><p>Ivakhnenko Igor A. - head of Medical Dept.</p><p>Nizhnevartovsk</p></bio><email xlink:type="simple">igornv86@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-9002-1234</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьев</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoriev</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Григорьев Павел Александрович - врач-онколог онкологического отделения абдоминальной и торакальной онкологии.</p><p>Ханты-Мансийск</p></bio><bio xml:lang="en"><p>Grigoriev Pavel A. - oncologist at Dept Abdominal and Thoracic Oncology.</p><p>Khanty-Mansiysk</p></bio><email xlink:type="simple">pgrigoryev@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5872-6035</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Билан</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bilan</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Билан Евгений Викторович - зам. руководителя по онкологии.</p><p>Ханты-Мансийск</p></bio><bio xml:lang="en"><p>Bilan Evgeniy V. - head of Medical Dept.</p><p>Khanty-Mansiysk</p></bio><email xlink:type="simple">zingel73@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4194-8166</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагулина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragulina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рагулина Нина Владимировна - старший преподаватель кафедры общей и факультетской хирургии.</p><p>Ханты-Мансийск</p></bio><bio xml:lang="en"><p>Ragulina Nina V. - assistant at Dept of General and Faculty Surgery.</p><p>Khanty-Mansiysk</p></bio><email xlink:type="simple">academic-77@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>БУ ВО ХМАО – Югры «Сургутский государственный университет»; БУ «Сургутская окружная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Surgut State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>БУ «Сургутская окружная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Surgut State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>БУ «Нижневартовский онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nizhnevartovsk Oncology Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>БУ «Окружная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>District Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>БУ «Ханты-Мансийская государственная медицинская академия»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Khanty-Mansiysk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>03</day><month>07</month><year>2025</year></pub-date><volume>0</volume><issue>11</issue><issue-title>«Диагностика и онкотерапия» (1)</issue-title><fpage>25</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аксарин А.А., Тер-Ованесов М.Д., Копейка С.М., Волкивский А.Б., Ивахненко И.А., Григорьев П.А., Билан Е.В., Рагулина Н.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Аксарин А.А., Тер-Ованесов М.Д., Копейка С.М., Волкивский А.Б., Ивахненко И.А., Григорьев П.А., Билан Е.В., Рагулина Н.В.</copyright-holder><copyright-holder xml:lang="en">Aksarin A.A., Ter-Ovanesov M.D., Kopeyka S.M., Volkivskiy A.B., Ivakhnenko I.A., Grigoriev P.A., Bilan E.V., Ragulina N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4423">https://www.med-alphabet.com/jour/article/view/4423</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Мелкоклеточный рак легкого (МРЛ) является одной из самых агрессивных форм опухолей. В настоящее время продолжаются дискуссии о роли хирургии в лечении больных МРЛ.</p></sec><sec><title>Цель</title><p>Цель. Оценить прогностическое влияние хирургии на отдаленные результаты лечения больных мелкоклеточным раком легкого. Материалы и методы. Материалом для исследования послужили 7549 больных раком легкого, диагностированные в Югре с 2002 по 2022 г. В исследование включен 71 пациент с МРЛ, перенесший радикальное хирургическое лечение. Лобэктомия была выполнена у 49 пациентов, пневмонэктомия – у 22. Систематическая лимфодиссекция (СЛД) выполнена 59 пациентам (83,1 %).</p></sec><sec><title>Результаты</title><p>Результаты. В I стадию десятилетняя выживаемость составила 65,8 %, во II стадию – 33,2 %, в III стадию – 14,4 %. Отдаленные результаты хирургического лечения МРЛ имели существенную зависимость от состояния региональных лимфоузлов: при N 0 10-я ОВ была 53,1 %, при N1 10-я ОВ – 30,6 %, при N 2–15,1 %. Десятилетняя выживаемость при СЛД значительно превосходила другие вмешательства на лимфатическом коллекторе и составила 42,0 %, в то время как при селективной лимфодиссекции 10-я ОВ была только 20,0 %.</p></sec><sec><title>Выводы</title><p>Выводы. Удовлетворительные отдаленные результаты у больных с I и II стадией МРЛ указывают на необходимость включения в лечебный арсенал радикального хирургического компонента в комплексное лечение больных МРЛ. Оптимальным объемом хирургического лечения является лобэктомия с систематической лимфодиссекцией. Хирургическое лечение может быть проведено у больных с IIIА и IIIB стадией МРЛ при регрессе опухоли после индукционной лекарственной терапии или химиолучевой терапии, а также в случае развития жизнеугрожающих осложнений. Для определения показаний к хирургическому лечению в данной когорте больных требуется проведение проспективных исследований.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Small cell lung cancer (SCLC) is one of the most aggressive forms of lung tumors. Currently, there are ongoing discussions about the role of surgery in the treatment of patients with SCLC.</p></sec><sec><title>The purpose of the study</title><p>The purpose of the study: does surgery improve prognosis in patients with small-cell lung cancer (SCLC)?</p></sec><sec><title>Methods</title><p>Methods. The material for the study was 7549 patients with lung cancer diagnosed in Ugra from 2002 to 2022. 71 SCLC with stage I to III undergoing surgical resection were enrolled. Lobectomy was performed in 49 patients, pneumonectomy in 22. Systematic nodal dissection (SND) was performed in 59 patients (83.1 %).</p></sec><sec><title>Results</title><p>Results. In stage I, the ten-year overall survival rate was 65.8 %, in stage II – 33.2 %, in stage III – 14.4 % (p=0,001). Remote results of surgical treatment of SCLC had a significant dependence on the state of regional lymph nodes: with N 0, the 10-year OS was 53.1 %, with N 1 the 10-year OS was 30.6 %, with N 2–15.1 % (p=0,003). Ten-year OS with SND was significantly exceeded other dissections on the lymphatic collector to 42.0 %, while with sampling nodal dissection the 10-year OS was only 20.0 % (p=0,028).</p></sec><sec><title>Conclusion</title><p>Conclusion. Good remote results in patients with stage I and II SCLC indicate the need to include surgery in the complex treatment of patients with SCLC. The optimal volume of surgery is lobectomy with systematic nodal dissection. Surgery can be performed in patients with stage IIIA and IIIB SCLC in case of tumor regression after induction chemoor chemoradiotherapy, as well as in case of life-threatening complications. Prospective studies are required to determine the indications for surgery in this cohort of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>мелкоклеточный рак легкого</kwd><kwd>хирургическое лечение</kwd><kwd>лобэктомия</kwd><kwd>пневмонэктомия</kwd><kwd>систематическая лимфодиссекция</kwd><kwd>селективная лимфодиссекция</kwd><kwd>общая выживаемость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>small cell lung cancer</kwd><kwd>surgery</kwd><kwd>lobectomy</kwd><kwd>pneumonectomy</kwd><kwd>systematic nodal dissection</kwd><kwd>sampling nodal dissection</kwd><kwd>overall survival</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Miller AB, Fox W, Tall R. Five-year follow-up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oatcelled carcinoma of the bronchus. 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