medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-9-37-42medalphabet-4384Research ArticleСтатьиСывороточный кальпротектин в роли маркера активации аутоиммунитета при ревматических заболеванияхSerum calprotectin as a marker of autoimmunity activation in rheumatologic diseaseshttps://orcid.org/0000-0001-5127-611XСпицинаС. С.SpitsinaS. S.

Спицина Светлана Сергеевна - м.н.с. клинико-биохимической лаборатории ФГБНУ «НИИ КИЭР им А.Б. Зборовского»; ассистент кафедры госпитальной терапии, ВПТ ФГБОУ ВО «ВолгГМУ» Минздрава России.

Волгоград

Svetlana S. Spitsina - research assistant at Clinical Biochemistry Laboratory, Rеsearсh Institute of Cliniсаl and Ехреrimеntal Rhеumatology named aftеr A.B. Zborovsky; assistant at Hospital Therapy Dept, Volgograd State Medical University.

Volgograd

ssspitsina@mail.ruhttps://orcid.org/0000-0002-0438-8554ШиловаЛ. Н.ShilovaL. N.

Шилова Людмила Николаевна - д.м.н., доцент, зав. кафедрой госпитальной терапии, ВПТ.

Волгоград

Ludmila N. Shilova - DM Sci (habil.), associate professor, head of Hospital Ttherapy Dept.

Volgograd

ludshilova@mail.ruhttps://orcid.org/0000-0003-0373-5072МозговаяЕ. Э.MozgovayaE. E.

Мозговая Елена Эдуардовна - к.м.н., в.н.с. клинико-биохимической лаборатории.

Волгоград

Elena E. Mozgovaya - PhD Med, leading researcher at Clinical Biochemistry Laboratory.

Volgograd

nauka@pebma.orghttps://orcid.org/0000-0002-5316-0185БединаС. A.BedinaS. A.

Бедина Светлана Александровна - к.м.н., с.н.с. клинико-биохимической лаборатории.

Волгоград

Svetlana A. Bedina - PhD Med, senior researcher at Clinical Biochemistry Laboratory.

Volgograd

clinicalbiochemistry@yandex.ruhttps://orcid.org/0000-0002-1627-8483ТрофименкоА. С.TrofimenkoA. S.

Трофименко Андрей Степанович - к.м.н., зав. клинико-биохимической лабораторией.

Волгоград

Andrei S. Trofimenko - PhD Med, head of Clinical Biochemistry Laboratory.

Volgograd

a.s.trofimenko@mail.ruФГБНУ «Научно-исследовательский институт клинической и экспериментальной ревматологии имени А.Б. Зборовского; ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава РоссииРоссияRеsearсh Institute of Cliniсаl and Ехреrimеntal Rhеumatology named aftеr A.B. Zborovsky; Volgograd State Medical UniversityRussian FederationФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава РоссииРоссияVolgograd State Medical UniversityRussian FederationФГБНУ «Научно-исследовательский институт клинической и экспериментальной ревматологии имени А.Б. Зборовского»РоссияRеsearсh Institute of Cliniсаl and Ехреrimеntal Rhеumatology named aftеr A.B. ZborovskyRussian Federation20250606202509Ревматология в общей врачебной практике (1)3742Copyright © Спицина С.С., Шилова Л.Н., Мозговая Е.Э., Бедина С.A., Трофименко А.С., 20252025Спицина С.С., Шилова Л.Н., Мозговая Е.Э., Бедина С.A., Трофименко А.С.Spitsina S.S., Shilova L.N., Mozgovaya E.E., Bedina S.A., Trofimenko A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4384

Кальпротектин – гетеродимер, образованный двумя белками, S100A8 и S100A9, которые в основном продуцируются активированными моноцитами и нейтрофилами. Роль кальпротектина в патогенезе, диагностике и мониторинге ревматических заболеваний привлекает большое внимание в последние годы. Согласно современным данным, циркулирующий сывороточный кальпротектин может рассматриваться в качестве маркера воспалительного процесса, обусловленного активностью нейтрофилов. Обнаружена связь между его высоким уровнем с некоторыми тяжелыми проявлениями аутоиммунных заболеваний, например, такими как гломерулонефрит, фиброз легких. Также представляет интерес его потенциальная роль мишени для лекарственной терапии, индикатора прогноза терапевтического ответа на лечение. В данной статье рассмотрены ключевые биологические функции кальпротектина, которые могут быть вовлечены в этиопатогенез ревматологических заболеваний, представляющие его потенциальное использование в качестве биомаркера данных патологий.

Calprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils. The role of calprotectin in the pathogenesis, diagnosis and monitoring of rheumatic diseases has attracted a high attention in the last years. According to modern data, circulating serum calprotectin can be considered as a marker of the inflammatory process due to neutrophil activity. An association between its high level and some severe manifestations of autoimmune diseases, such as glomerulonephritis and pulmonary fibrosis, has been found. Also, of interest is its potential role as a target for drug therapy, an indicator of prognosis of therapeutic response to treatment. This article reviews the key biological functions of calprotectin that may be involved in the pathogenesis of rheumatologic diseases, presenting its potential use as a biomarker of these pathologies.

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The authors declare that there are no conflicts of interest present.