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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2025-8-106-110</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4370</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Опыт применения комплексного препарата гибридной полимолочной кислоты в коррекции инволютивных изменений кожи</article-title><trans-title-group xml:lang="en"><trans-title>Experience of using a complex preparation of hybrid polylactic acid in the correction of involutional changes in the skin</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8182-7293</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ногеров</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Nogerov</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ногеров Алим Русланович, к.м.н., врач-дерматовенеролог, косметолог; доцент кафедры дерматовенерологии и косметологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Nogerov Alim R., PhD Med, dermatovenerologist, cosmetologist; associate professor at Dept of Dermatovenerology and Cosmetology</p><p>Moscow</p></bio><email xlink:type="simple">drnogerov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Клиника косметологии и интегративной медицины Nogerov International Clinic; ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nogerov International Clinic of Cosmetology and Integrative Medicine; Central State Medical Academy of the Administrative Department of the President of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>04</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>8</issue><issue-title>Дерматология (1)</issue-title><fpage>106</fpage><lpage>110</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ногеров А.Р., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ногеров А.Р.</copyright-holder><copyright-holder xml:lang="en">Nogerov A.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4370">https://www.med-alphabet.com/jour/article/view/4370</self-uri><abstract><sec><title>Материал и методы</title><p>Материал и методы. Под наблюдением находилось 20 пациентов женского пола в возрасте от 30 до 40 лет (медиана 36,7±1,9 лет), обратившиеся на прием с жалобами на инволютивные изменения кожи лица (ксероз, снижение тургора, морщины). Всем пациентам проводили процедуры инъекционной терапии: препарат Lenisna – контурная пластика лица (височная область, область щек, подбородок), препарат JuveLook – для периорбитальной области. Эффективность оценивалась с применением шкалы SASSQ, качественных характеристик кожи (гидратация, эластичность, выраженность морщин).</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования. Динамика показателя шкалы SASSQ составила 45,6%, гидратация кожи увеличилась практически в 2 раза, показатель эластичности увеличился на 41,7%, показатель «выраженность морщин» снизился на 16,7%.</p></sec><sec><title>Вывод</title><p>Вывод. Применение препаратов Lenisna и JuveLook, содержащих PDLLA и ГК, позволяет значительно улучшить качественные характеристики кожи и восполнить объем тканей при инволютивных изменениях.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Material and methods</title><p>Material and methods. We observed 20 female patients aged 30 to 40 years (median 36.7±1.9 years) who came to the appointment with complaints of involutional changes in the facial skin (xerosis, decreased turgor, wrinkles). All patients underwent injection therapy procedures: Lenisna – facial contouring (temporal area, cheek area, chin), JuveLook – for the periorbital area. Efficiency was assessed using the SASSQ scale, qualitative characteristics of the skin (hydration, elasticity, severity of wrinkles).</p></sec><sec><title>Results of the study</title><p>Results of the study. The dynamics of the SASSQ scale was 45.6%, skin hydration increased almost 2 times, the elasticity index increased by 41.7%, the «severity of wrinkles» index decreased by 16.7%.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of Lenisna and JuveLook preparations containing PDLLA and HA allows to significantly improve the qualitative characteristics of the skin and restore tissue volume in case of involutional changes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инволютивные изменения кожи</kwd><kwd>полимолочная кислота</kwd><kwd>PDLLA</kwd><kwd>гиалуроновая кислота</kwd><kwd>качественные характеристики кожи</kwd></kwd-group><kwd-group xml:lang="en"><kwd>involutional changes of the skin</kwd><kwd>polylactic acid</kwd><kwd>PDLLA</kwd><kwd>hyaluronic acid</kwd><kwd>qualitative characteristics of the skin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аленичев А.Ю., Круглова Л.С., Федоров С.М., Шарыпова И.В. Оценка эффективности применения микроигольчатой RF-терапии в коррекции инволютивных изменений кожи лица и шеи. 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