medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-10-74-78medalphabet-4325Research ArticleСтатьиВлияние туберкулеза легких на стоматологический статус (обзор)Clinical case: chronic generalized periodontitis in a patient, which have infiltrative pulmonary tuberculosishttps://orcid.org/0009-0005-3875-3942ЛунинаН. А.LuninaN. A.

Лунина Наталия Александровна – к.м.н., доцент кафедры терапевтической стоматологии,

Воронеж

Lunina Nataliya Alexandrovna – Candidate of Medical Sciences, Associate Professor ofthe Department of Therapeutic Dentistry,

Voronezh

natikvel@mail.ruhttps://orcid.org/0000-0002-0769-8427ВеликаяО. В.VelikayaO. V.

Великая Ольга Викторовна – д.м.н., профессор, заведующий кафедрой фтизиатрии,

Воронеж

Velikaya Olga Viktorovna – Doctor of Medical Sciences, Professor, Head of the Department of Phthisiology,

Voronezh

vgma-velikaya@yandex.ruhttps://orcid.org/0000-0002-3115-4729СущенкоА. В.OleinikO. I.

Сущенко Андрей Валерьевич – д.м.н., профессор, заведующий кафедры терапевтической стоматологии,

Воронеж

Sushchenko Andrey Valerievich – Doctor of Medical Sciences, Professor, Head of theDepartment of Therapeutic Dentistry,

Voronezh

avs270270@mail.ruhttps://orcid.org/0000-0002-5890-3988ОлейникО. И.SushchenkoA. V.

Олейник Ольга Игоревна – д.м.н., профессор кафедры терапевтической стоматологии,

Воронеж

Oleinik Olga Igorevna – Doctor of Medical Sciences, Professor of the Department ofTherapeutic Dentistry,

Voronezh

dr.olgaoleynik@yandex.ruШабановР. А.ShabanovR. A.

Шабанов Руслан Анатольевич – к.м.н., доцент кафедры терапевтической стоматологии,

Воронеж

Shabanov Ruslan Anatolyevich – PhD, Associate Professor of the Department of Therapeutic Dentistry,

Voronezh

ilya5habanov@yandex.ruАлиевН. Т.AlievN. T.

Алиев Нахид Тофикович оглы – ассистент кафедры терапевтической стоматологии,

Воронеж

Aliev Nahid Tofikovich ogly – Assistant of the Department of Therapeutic Dentistry,

Voronezh

ФГБОУ ВО «Воронежский государственный медицинский университет имени Н.Н. Бурденко» Министерства здравоохранения Российской ФедерацииРоссияVoronezh State Medical University named after N.N. BurdenkoRussian Federation202521052025010Стоматология (2)7478Copyright © Лунина Н.А., Великая О.В., Сущенко А.В., Олейник О.И., Шабанов Р.А., Алиев Н.Т., 20252025Лунина Н.А., Великая О.В., Сущенко А.В., Олейник О.И., Шабанов Р.А., Алиев Н.Т.Lunina N.A., Velikaya O.V., Oleinik O.I., Sushchenko A.V., Shabanov R.A., Aliev N.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4325

На сегодняшний день в клинической практике все чаще встречаются стоматологические заболевания с коморбидной патологией. Ранние исследования показали, что наблюдается связь между развитием и течением хронических инфекционных заболеваний, включая туберкулез легких, и нарушением баланса процессов перекисного окисления липидов, эндогенной интоксикацией, а также локального и общего воспалительного процесса и дисфункцией иммунной системы. В тоже время, ученые все еще озадачены ролью основных патофизиологических и патогенетических факторов в развитии и прогрессировании заболеваний пародонта у пациентов с хронической инфекционной патологией.

Today, dental diseases with comorbid pathology are increasingly encountered in clinical practice. Early studies have shown that there is a connection between the development and course of chronic infectious diseases, including pulmonary tuberculosis, and an imbalance in lipid peroxidation processes, endogenous intoxication, as well as local and general inflammatory process and dysfunction of the immune system. At the same time, scientists are still puzzled by the role of the main pathophysiological and pathogenetic factors in the development and progression of periodontal diseases in patients with chronic infectious pathology. The purpose of this literature review was to analyze the factors affecting the dental status, including pulmonary tuberculosis, as a comorbid disease. Further study of this problem and preventive measures can significantly reduce the quantitative indicator of these diseases.

стоматологический статускоморбидная патологиятриггерпародонтокомплексфармакологическая нагрузкаdental statuscomorbid pathologytriggerperiodontal complexpharmacological loadReferencesMishchenko M.A., Kononova S.V. Analysis factors the commitment to gipolipidemicescoy therapy / Medical almanac. 2014. N1 (31). – Pp. 95–98.Mishchenko M.A., Kononova S.V. Analysis factors the commitment to gipolipidemicescoy therapy / Medical almanac. 2014. N1 (31). – Pp. 95–98.Nechaeva O. B. Epidemic software situation tuberculosis in Russia / Tuberculosis and diseases lungs. – 2018. – Vol. 96, No. 8, Pp. 15-24. DOI 10.21292/2075-1230- 2018-96-8-15-24.Nechaeva O. B. Epidemic software situation tuberculosis in Russia / Tuberculosis and diseases lungs. – 2018. – Vol. 96, No. 8, Pp. 15-24. DOI 10.21292/2075-1230- 2018-96-8-15-24.Vasileva I.A. Epidemiology TB and TB / HIV in Russian Federation. Problems and solutions [Electronic resource] https://doi.org/10.21292/2075-1230-2017-95-9-8-18. Date of access: 21.01.2024.Vasileva I.A. Epidemiology TB and TB / HIV in Russian Federation. Problems and solutions [Electronic resource] https://doi.org/10.21292/2075-1230-2017-95-9-8-18. Date of access: 21.01.2024.World Health Organization. WHO treatment guidelines for isoniazid-resistant tuberculosis: Supplement to the WHO treatment guidelines for drug-resistant tuberculosis. http://www.who.int/tb/publications/2018/WHO_guidelines_isoniazid_resistant_TB/en/ Date of access: 21.01.2024.World Health Organization. WHO treatment guidelines for isoniazid-resistant tuberculosis: Supplement to the WHO treatment guidelines for drug-resistant tuberculosis. http://www.who.int/tb/publications/2018/WHO_guidelines_isoniazid_resistant_TB/en/ Date of access: 21.01.2024.Sundar IK, Javed F, Romanos GE, Rahman I. E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget 2016; 7:77196. DOI: 10.18632/oncotarget.12857.Sundar IK, Javed F, Romanos GE, Rahman I. E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget 2016; 7:77196. DOI: 10.18632/oncotarget.12857.Worthington HV, MacDonald L, Poklepovic Pericic T, et al. Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries. Cochrane Database Syst Rev 2019; 4:CD012018. DOI: 10.1002/14651858.CD012018.pub2.Worthington HV, MacDonald L, Poklepovic Pericic T, et al. Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries. Cochrane Database Syst Rev 2019; 4:CD012018. DOI: 10.1002/14651858.CD012018.pub2.Aggressive periodontitis. In: Online Mendelian Inheritance in Man. Johns Hopkins University. http://omim.org/entry/170650 Date of access: 21.01.2024. 8. Miller K, Treloar T, Guelmann M, et al. Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. J Clin Pediatr Dent 2018; 42:95. DOI: 10.17796/1053-4628-42.2.3.Aggressive periodontitis. In: Online Mendelian Inheritance in Man. Johns Hopkins University. http://omim.org/entry/170650 Date of access: 21.01.2024. 8. Miller K, Treloar T, Guelmann M, et al. Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. J Clin Pediatr Dent 2018; 42:95. DOI: 10.17796/1053-4628-42.2.3.Fine DH, Armitage GC, Genco RJ, et al. Unique etiologic, demographic, and pathologic characteristics of localized aggressive periodontitis support classification as a distinct subcategory of periodontitis. J Am Dent Assoc 2019; 150:922. DOI:10.1016/j.adaj.2019.07.024.Fine DH, Armitage GC, Genco RJ, et al. Unique etiologic, demographic, and pathologic characteristics of localized aggressive periodontitis support classification as a distinct subcategory of periodontitis. J Am Dent Assoc 2019; 150:922. DOI:10.1016/j.adaj.2019.07.024.Laskaris G, Tatakis DN, Stoufi E. Periodontal manifestations of local and systemic diseases: Colour atlas and text, Springer, Berlin 2022. DOI:10.1007/978-3-031-10828-0.Laskaris G, Tatakis DN, Stoufi E. Periodontal manifestations of local and systemic diseases: Colour atlas and text, Springer, Berlin 2022. DOI:10.1007/978-3-031-10828-0.Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018; 45 Suppl 20:S219.Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018; 45 Suppl 20:S219.Faustino ISP, Fernandes PM, Pontes HAR, et al. Langerhans cell histiocytosis in the oral and maxillofacial region: An update. J Oral Pathol Med 2021;50:565. DOI: 10.1111/jop.13207.Faustino ISP, Fernandes PM, Pontes HAR, et al. Langerhans cell histiocytosis in the oral and maxillofacial region: An update. J Oral Pathol Med 2021;50:565. DOI: 10.1111/jop.13207.Neves-Silva R, Fernandes DT, Fonseca FP, et al. Oral manifestations of Langerhans cell histiocytosis: A case series. Spec Care Dentist 2018;38:426. DOI: 10.1111/scd.12330.Neves-Silva R, Fernandes DT, Fonseca FP, et al. Oral manifestations of Langerhans cell histiocytosis: A case series. Spec Care Dentist 2018;38:426. DOI: 10.1111/scd.12330.Cammarata-Scalisi F, Girardi K, Strocchio L, et al. Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia. Cancers (Basel) 2020;12. DOI: 10.3390/cancers12061634.Cammarata-Scalisi F, Girardi K, Strocchio L, et al. Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia. Cancers (Basel) 2020;12. DOI: 10.3390/cancers12061634.Halai H, Somani C, Donos N, Nibali L. Periodontal status of children with primary immunodeficiencies: a systematic review. Clin Oral Investig 2020;24:1939. DOI: 10.1007/s00784-019-03055-z.Halai H, Somani C, Donos N, Nibali L. Periodontal status of children with primary immunodeficiencies: a systematic review. Clin Oral Investig 2020;24:1939. DOI: 10.1007/s00784-019-03055-z.Carlsson G, Wahlin YB, Johansson A, et al. Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. J Periodontol 2006; 77:744. DOI: 10.1902/jop.2006.050191.Carlsson G, Wahlin YB, Johansson A, et al. Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. J Periodontol 2006; 77:744. DOI: 10.1902/jop.2006.050191.Zainal Abidin Z, Zainuren ZA, Noor E, et al. Periodontal health status of children and adolescents with diabetes mellitus: a systematic review and meta-analysis. Aust Dent J 2021; 66 Suppl 1:S15. DOI: 10.1111/adj.12845.Zainal Abidin Z, Zainuren ZA, Noor E, et al. Periodontal health status of children and adolescents with diabetes mellitus: a systematic review and meta-analysis. Aust Dent J 2021; 66 Suppl 1:S15. DOI: 10.1111/adj.12845.Клинические рекомендации «Туберкулез у взрослых», 2024 URL: https://rof-tb.ru/structure/ (дата обращения: 25.01.2025).Clinical guidelines «Tuberculosis in adults», 2024 URL: https://rof-tb.ru/structure/ (date of access: 01/25/2025).Yilmaz D, Caglayan F, Buber E, et al. Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clin Oral Investig 2018; 22:2135. DOI: 10.1007/s00784-018-2469-z.Yilmaz D, Caglayan F, Buber E, et al. Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clin Oral Investig 2018; 22:2135. DOI: 10.1007/s00784-018-2469-z.Зейналова Н.В. Морфогистологические и бактериоскопические данные полости рта у больных туберкулезом легких / Вестник проблем биологии и медицины. 2013. Т. 1(104). № 4. С. 322–324.Zeynalova N.V. Morphohistological and bacterioscopic data of the oral cavity in patients with pulmonary tuberculosis / Bulletin of Problems of Biology and Medicine. 2013. Vol. 1(104). No. 4. P. 322–324.Садыев Р.К. Состояние органов и тканей полости рта у больных туберкулезом (обзор литературы) / Наука и новые технологии. 2009. № 5. С. 72–76.Sadyev R.K. The state of organs and tissues of the oral cavity in patients with tuberculosis (literature review) / Science and new technologies. 2009. No. 5. P. 72–76.Chakraborty P, Chowdhury R, Bhakta A, et al. Microbiology of periodontal disease in adolescents with Type 1 diabetes. Diabetes Metab Syndr 2021;15:102333. DOI: 10.1016/j.dsx.2021.102333.Chakraborty P, Chowdhury R, Bhakta A, et al. Microbiology of periodontal disease in adolescents with Type 1 diabetes. Diabetes Metab Syndr 2021;15:102333. DOI: 10.1016/j.dsx.2021.102333.Chakraborty P, Mukhopadhyay P, Bhattacharjee K, et al. Periodontal Disease in Type 1 Diabetes Mellitus: Influence of Pubertal Stage and Glycemic Control. Endocr Pract 2021;27:765. DOI: 10.1016/j.eprac.2021.01.010.Chakraborty P, Mukhopadhyay P, Bhattacharjee K, et al. Periodontal Disease in Type 1 Diabetes Mellitus: Influence of Pubertal Stage and Glycemic Control. Endocr Pract 2021;27:765. DOI: 10.1016/j.eprac.2021.01.010.Лунина Н.А., Великая О.В., Олейник О.И., Сущенко А.В. Хронический генерализованный пародонтит у пациента с инфильтративным туберкулезом легких / Актуальные проблемы медицины. 2024. Т. 47. № 2. С. 219–228.Lunina N.A., Velikaya O.V., Oleynik O.I., Sushchenko A.V. Chronic generalized periodontitis in a patient with infiltrative pulmonary tuberculosis / Actual problems of medicine. 2024. V. 47. N 2. P. 219–228.Лунина Н.А., Великая О.В., Олейник О.И. Туберкулез легких как фактор риска развития хронического генерализованного пародонтита / Системный анализ и управление в биомедицинских системах. 2023. Т. 22. № 2. С. 149–153.Lunina N.A., Velikaya O.V., Oleynik O.I. Pulmonary tuberculosis as a risk factor for the development of chronic generalized periodontitis / Systems analysis and management in biomedical systems. 2023. Vol. 22. No. 2. P. 149–153.Галоян А.С., Загдын З.М. Оказание стоматологической помощи пациентам с туберкулезом (аналитический обзор) / Туберкулез и социально значимые заболевания. 2023. Т.11. № 1. С. 44–49. https://doi.org/10.54921/2413-0346-2023-11-1-44-49.Galoyan A.S., Zagdyn Z.M. Providing dental care to patients with tuberculosis (analytical review). Tuberculosis and socially significant diseases. 2023;11(1):44–49. (In Russ.) https://doi.org/10.54921/2413-0346-2023-11-1-44-49.Umlauft J, Schnabl D, Blunder S, et al. Two patients with Papillon-Lefèvre syndrome without periodontal involvement of the permanent dentition. J Dermatol 2021; 48:537. DOI: 10.1111/1346-8138.15720.Umlauft J, Schnabl D, Blunder S, et al. Two patients with Papillon-Lefèvre syndrome without periodontal involvement of the permanent dentition. J Dermatol 2021; 48:537. DOI: 10.1111/1346-8138.15720.Lettieri GM, Santiago LM, Lettieri GC, et al. Oral Phenotype and Salivary Microbiome of Individuals With Papillon-Lefèvre Syndrome. Front Cell Infect Microbiol 2021;11:720790. DOI: 10.3389/fcimb.2021.720790.Lettieri GM, Santiago LM, Lettieri GC, et al. Oral Phenotype and Salivary Microbiome of Individuals With Papillon-Lefèvre Syndrome. Front Cell Infect Microbiol 2021;11:720790. DOI: 10.3389/fcimb.2021.720790.Ризаев Ж.А., Хазратов А.И., Абдуллаев Т.З. влияние туберкулеза на стоматологической статус ротовой полости / Журнал проблемы биологии и медицины. 2022. №6(140). С. 397–400.Rizaev Zh.A., Khazratov A.I., Abdullaev T.Z. The influence of tuberculosis on the dental status of the oral cavity / Journal of Problems of Biology and Medicine. 2022. No. 6 (140). P. 397–400.Cortés-Bretón Brinkmann J, García-Gil I, Lobato-Peña DM, et al. The key role of the dental practitioner in early diagnosis of periodontal Ehlers-Danlos syndromes: a rare case report of siblings. Quintessence Int 2021; 52:166. DOI: 10.3290/j.qi.a45263.Cortés-Bretón Brinkmann J, García-Gil I, Lobato-Peña DM, et al. The key role of the dental practitioner in early diagnosis of periodontal Ehlers-Danlos syndromes: a rare case report of siblings. Quintessence Int 2021; 52:166. DOI: 10.3290/j.qi.a45263.Луцкая И.К. Кандидоз полости рта как следствие общих заболеваний или их медикаментозного лечения / Стоматология. 2021. № 8. С. 6–11.Lutskaya I.K. Oral candidiasis as a consequence of common diseases or their drug treatment / Dentistry. 2021. No. 8. P. 6–11.Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, et al. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet 2018; 392:821.Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, et al. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet 2018; 392:821.

The authors declare that there are no conflicts of interest present.