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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2025-4-26-32</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4284</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Индекс глобальной функции левого желудочка у условно здоровых лиц при эхокардиографическом исследовании</article-title><trans-title-group xml:lang="en"><trans-title>Left ventricular global function index in healthy individuals by echocardiography</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7072-9783</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капустина</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapustina</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капустина Анастасия Юрьевна - к.м.н., врач функциональной диагностики, ассистент кафедры терапии, кардиологии и функциональной диагностики с курсом нефрологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Anastasiya Yu. Kapustina - PhD, doctor of functional diagnostics, assistant professor Division of Therapy, Cardiology, Functional Diagnostics and Nephrology.</p><p>Moscow</p></bio><email xlink:type="simple">nast.capustina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1901-5728</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заренкова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zarenkova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заренкова Татьяна Анатольевна - врач функциональной диагностики.</p><p>Москва</p></bio><bio xml:lang="en"><p>Zarenkova A. Tatyana - doctor of functional diagnostics.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9725-7528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алёхин</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekhin</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алёхин Михаил Николаевич --- д.м.н., профессор, заведующий отделением функциональной диагностики, профессор кафедры терапии, кардиологии и функциональной диагностики с курсом нефрологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Mikhail N. Alekhin - MD, Professor, Head of Functional Diagnostics Department, Professor Division of Therapy, Cardiology, Functional Diagnostics and Nephrology.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Центральная клиническая больница с поликлиникой» УД Президента РФ; ФГБУ ДПО «Центральная государственная медицинская академия» УД Президента РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Clinical Hospital With Outpatient Clinic; Central State Medical Academy of Department of Presidential Affairs</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Центральная клиническая больница с поликлиникой» УД Президента РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Clinical Hospital With Outpatient Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><issue-title>Современная функциональная диагностика (1)</issue-title><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Капустина А.Ю., Заренкова Т.А., Алёхин М.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Капустина А.Ю., Заренкова Т.А., Алёхин М.Н.</copyright-holder><copyright-holder xml:lang="en">Kapustina A.Y., Zarenkova T.A., Alekhin M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4284">https://www.med-alphabet.com/jour/article/view/4284</self-uri><abstract><p>Одной из важнейших задач методов оценки сердечно-сосудистой визуализации является определение глобальной функции левого желудочка (ЛЖ). С этой целью обычно рассчитывают фракцию выброса ЛЖ (ФВ ЛЖ). Наряду с оценкой ФВ ЛЖ можно использовать глобальную продольную систолическую деформацию (ГПСД) ЛЖ или индекс глобальной функции ЛЖ (ИГФ ЛЖ), вычисляемые с помощью эхокардиографии (ЭхоКГ).</p><p>Целью данного исследования было определить значения ИГФ ЛЖ у условно здоровых лиц, сравнить между собой воспроизводимость различных показателей глобальной функции ЛЖ и изучить зависимость значений ИГФ ЛЖ от возраста и пола у условно здоровых лиц.</p><sec><title>Материалы и методы</title><p>Материалы и методы. В период с 2022 по 2023 гг. было обследовано 100 условно здоровых лиц, средний возраст которых составил 38,0±9,8 (36,1–40,0) лет. Из них у 20 случайно выбранных обследованных проводилась оценка внутрииндивидуальной и межиндивидуальной вариабельности показателей глобальной функции ЛЖ. Всем обследованным была проведена трансторакальная ЭхоКГ. ИГФ ЛЖ вычисляли с помощью эхокардиографии как отношение ударного объема ЛЖ к глобальному объему ЛЖ, который представляет собой сумму среднего объема полости ЛЖ и объема миокарда ЛЖ.</p></sec><sec><title>Результаты</title><p>Результаты. Определены нормальные значения ИГФ ЛЖ у условно здоровых лиц – 28,1±3,9%. Корреляционный анализ показал высокую тесноту связи показателей для внутрииндивидуальной и межиндивидуальной вариабельности в отношении ИГФ ЛЖ (р &lt;0,001, коэффициент Пирсона – 0,780 и коэффициент вариации – 5,1 для внутрииндивидуальной вариабельности, р &lt;0,001, коэффициент Пирсона – 0,725 и коэффициент вариации – 5,2 для межиндивидуальной вариабельности). Выявлены статистически значимые различия значений ИГФ ЛЖ у условно здоровых лиц в зависимости от возраста (р=0,002). Значения ИГФ ЛЖ у женщин (29,6±4,0%) были значимо выше, чем у мужчин (26,8±3,3%, р &lt;0,001).</p></sec><sec><title>Выводы</title><p>Выводы. Таким образом были определены значения ИГФ ЛЖ у условно здоровых лиц, полученные с помощью ЭхоКГ. По результатам исследования получены высокие показатели внутрииндивидуальной и межиндивидуальной вариабельности ИГФ ЛЖ. Выявлена зависимость значений ИГФ ЛЖ от возраста и пола обследованных условно здоровых лиц.</p></sec></abstract><trans-abstract xml:lang="en"><p>Determination of the global function of the left ventricle (LV) is one of the most important tasks of assessment of the methods of cardiovascular imaging. Nowadays ejection fraction LV (EF LV) and global longitudinal strain (GLS) calculated by echocardiography are widely used for this purpose. However, the methods have a number of limitations that require finding effective and accessible indicators that can be used in daily practice. One of the proposed indicators is LV global function index (LV GFI), calculated by echocardiography and taking into account cardiac remodeling.</p><p>The purpose of this study was to determine LV GFI values in healthy individuals, to compare the reproducibility of different rates of global function LV and to explore ratios depend LV GFI on age and gender in healthy individuals.</p><sec><title>Methods</title><p>Methods. Between 2022 and 2023. was examined included 100 healthy individuals with average age of 38.0±9.8 (36.1–40.0). Of these, 20 examined randomly selected assessed intraindividual and interindividual variability of global function LV. All patients were done a transthoracic echocardiography. The LV GFI by echocardiography was defined by the ratio of stroke volume divided by LV total volume defined as the sum of mean LV cavity and myocardial volumes.</p></sec><sec><title>Results</title><p>Results. The study determined normal LV GFI values in healthy persons – 28.1±3.9%. Correlation analysis showed a high degree of interrelation between the indicators for intraindividual and interindividual variability in relation to LV GFI (p &lt;0.001, Pearson correlation coefficient – 0.780 and coefficient of variation – 5.1 for intraindividual variability, p &lt;0.001, Pearson correlation coefficient – 0.725 and coefficient of variation – 5.2 for interindividual variability). The differences of LV GFI values were statistically significant according to age (p=0.002) in healthy individuals. LV GFI values were significantly higher (p &lt;0.001) in women (29.6±4.0%) than in men (26.8±3.3%).</p></sec><sec><title>Conclusions</title><p>Conclusions. LV GFI values were determined in healthy persons by echocardiography. The results of the study showed high intraindividual and interindividual variability of LV GFI. LV GFI values were dependent on age and gender of healthy persons.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>систолическая функция</kwd><kwd>левый желудочек</kwd><kwd>индекс глобальной функции левого желудочка</kwd><kwd>фракция выброса левого желудочка</kwd><kwd>ремоделирование левого желудочка</kwd><kwd>здоровые лица</kwd></kwd-group><kwd-group xml:lang="en"><kwd>systolic function</kwd><kwd>left ventricle</kwd><kwd>left ventricle global function index</kwd><kwd>left ventricular ejection fraction</kwd><kwd>left ventricle remodeling</kwd><kwd>healthy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Baron T, Berglund L, Hedin EM, et al. Test-retest reliability of new and conventional echocardiographic parameters of left ventricular systolic function. 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(In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
