medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-7-16-21medalphabet-4232Research ArticleСтатьиОсновные современные методы лечения генитоуринарного менопаузального синдромаThe main modern methods of treatment of genitourinary menopausal syndromehttps://orcid.org/0000-0002-2977-323XТихомироваЕ. В.TikhomirovaE. V.

Тихомирова Елена Владиславовна - к.м.н., зав. кафедрой «Сестринское дело».

Москва

Elena V. Tikhomirova - PhD Med, head of Dept of Nursing.

Moscow

heltik03@gmail.comhttps://orcid.org/0000-0002-2364-6838БаланВ. Е.BalanV. E.

Балан Вера Ефимовна - д.м.н., проф., проф. кафедры акушерства и гинекологии.

Москва

Vera E. Balan - DM Sci (habil.), professor, professor at Dept of Obstetrics and Gynecology.

Moscow

balanmed@gmail.comhttps://orcid.org/0000-0003-4424-9062ЧулковаЕ. А.ChulkovaE. A.

Чулкова Елена Александровна - к.м.н., зав. кафедрой внутренних болезней.

Москва

Elena A. Tchoulkova - PhD Med, head of Dept of Internal Medicine.

Moscow

chulkova.synergy@yandex.ruhttps://orcid.org/0009-0000-0176-4588ОрлюкМ. A.OrlyukM. A.

Орлюк Мария Анатольвена - к.м.н., зав. кафедрой «Хирургические болезни».

Москва

Maria A. Orlyuk - PhD Med, head of Dept of Surgical Diseases.

Moscow

4677437@inbox.ruhttps://orcid.org/0000-0002-4222-5932АбанинаО. В.AbaninaO. V.

Абанина Ольга Вячеславовна - к.м.н., декан медицинского факультета.

Москва

Olga V. Abanina - PhD Med, dean of the Faculty of Medicine.

Moscow

olga32100@yandex.ruМоисееваЕ. К.MoiseevaE. K.

Моисеева Елена Константиновна - руководитель образовательных программ СПО медицинского факультета.

Москва

Elena K. Moiseeva - head of Educational Programs of Secondary Vocational Education of the Faculty of Medicine.

Moscow

ekmoisttva@list.ruЯцюкВ. Я.YatsyukV. Ya.

Яцюк Валентина Яковлевна, д.фарм.н., проф., проф. кафедры общей и биоорганической химии.

Курск

Valentina Ya. Yatsyuk - Dr Pharmaceutical Sci, professor, professor at Dept of General and Bioorganic Chemistry.

Kursk

oxana7712@mail.ruНОУ ВО «Московский финансово-промышленный университет „Синергия“»РоссияMoscow University for Industry аnd Finance “Synergy”Russian FederationКафедра акушерства и гинекологии ФУВ «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияDept of Obstetrics and Gynecology, Faculty of Improvement of Doctors at M.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian FederationФГБОУ ВО «Курский государственный медицинский университет» Минздрава РоссииРоссияKursk State Medical UniversityRussian Federation20252303202507Современная гинекология (1)1621Copyright © Тихомирова Е.В., Балан В.Е., Чулкова Е.А., Орлюк М.A., Абанина О.В., Моисеева Е.К., Яцюк В.Я., 20252025Тихомирова Е.В., Балан В.Е., Чулкова Е.А., Орлюк М.A., Абанина О.В., Моисеева Е.К., Яцюк В.Я.Tikhomirova E.V., Balan V.E., Chulkova E.A., Orlyuk M.A., Abanina O.V., Moiseeva E.K., Yatsyuk V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4232

Симптомы генитоуринарного менопаузального синдрома (ГУМС) появляются одновременно с вазомоторными симптомами при наступлении менопаузы и даже в перименопаузе: болезненность, зуд и сухость во влагалище, диспареуния и т.д. Это связано с развитием атрофических изменений в урогенитальном тракте, что резко снижает качество жизни женщин и является фактором риска развития рецидивирующих инфекций мочеполовой системы. Более 65 % женщин в постменопаузе без системной менопаузальной гормональной терапии (МГТ) страдают проявлениями урогенитальной атрофии. В данной статье рассматриваются современные способы лечения ГУМС, описываются различные методы лечения, их эффективность, длительность применения. В качестве первой линии терапии рекомендуются негормональные смазочные гели. При средней и тяжелой степени вульвовагинальной атрофии и при отсутствии противопоказаний применяют локальное интравагинальное введение эстриола. Описаны и новые перспективные методы лечения ГУМС: оспемифен – пероральный активный селективный модулятор рецепторов эстрогенов (SERM), лазерная терапия, дегидроэпиандростерон.

Выводы. Генитоуринарный менопаузальный синдром – недооцененное распространенное заболевание, но частота применения локальных эстрогенов все еще низкая. Лечение следует продолжать длительно для предупреждения рецидивов симптомов ГУМС. Вагинальные увлажнители могут использоваться как в монотерапии, так и в сочетании с эстриолом.

Symptoms of the genitourorinar menopausal syndrome appear simultaneously with vasomotor symptoms when menopause and even in perimenopause: soreness, itching and dryness in the vagina, dyspareunia, etc. This is due to the developmental atrophic changes in the urogenital tract, which sharply reduces the quality of life and is a risk factor for the development of recurrent infections of the genitourinary system. More than 65% of women in postmenopause without systemic menopausal hormonal therapy (MGT) suffer from manifestations of urogenital atrophy. This article discusses all modern methods of treating HUMS, describes various methods of treatment, their effectiveness, duration of application. As the first line of therapy, non -hormonal lubricants are recommended. With an average and severe degree of vulvovaginal atrophy and in the absence of contraindications, local intravaginal administration of estriol is used. The new promising methods of treatment with the State Unitary Enterprise are also described: Ospemicifen-oral, active selective selective modhertator of estrogen receptors (SERM), laser therapy, dehydroepiapianrosterone.

Conclusions. Genitouine menopausal syndrome – an underestimated common disease, but the frequency of use of local estrogens is low. Treatment should be continued for a long time to prevent relapse of the symptoms of Hums. Vaginal moisturizers can be used both in monotherapy and in combination with estriol.

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The authors declare that there are no conflicts of interest present.