medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-7-51-60medalphabet-4229Research ArticleСтатьиНутритивная поддержка ооцитогенеза, овуляторных менструальных циклов витаминами фолатного цикла (витаминами В1, В6, В12, активной формой В9) и витамерами витамина В8 (Мио- и D-хироинозитол в соотношении 40:1) при предгравидарной подготовкеNutritional support of oocyteogenesis, ovulatory menstrual cycles with folate cycle vitamins (vitamins B1, B6, B12, active form B9) and vitamin B8 vitamers (Myo- and D-chiroinositol in a ratio of 40:1) during pre-conception preparationhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна - д. м. н., проф., в н. с., научный руководитель.

Москва

AuthorID 94901, Scopus Author ID 7003589812, WOS ID J4946–2017

Olga A. Gromova - DM Sci (habil.), prof., leading researcher, scientific supervisor, leading researcher.

Moscow

Scopus Author ID 7003589812, WOS ID J4946–2017

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич - к.ф-м.н., к. х. н., с. н. с.

Москва

Scopus Author ID 7003300274, Author ID 54104, WOS ID C‑7683–2018

Ivan Yu. Torshin - PhD in Applied Mathematics, PhD Chemical Sci, senior researcher.

Moscow

Scopus Author ID 7003300274, AuthorID 54104, WOS ID C‑7683–2018

ТетруашвилиН. К.TetruashviliN. K.

Тетруашвили Нана Картлосовна - д. м. н., зав. 2-м отделением акушерским патологии беременности.

Москва

Nana K. Tetruashvili - DM Sci (habil.), head of Dept of Pregnancy Loss Prevention and Therapy.

Moscow

n_tetruashvili@oparina4.ruФГУ «Федеральный исследовательский центр „Информатика и управление“» Российской академии наукРоссияFederal Research Centre ‘The Informatics and Management’Russian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава РоссииРоссияNational Medical Research Center of Obstetrics, Gynecology and Perinatology n.a. academician V.I. KulakovRussian Federation20252303202507Современная гинекология (1)5160Copyright © Громова О.А., Торшин И.Ю., Тетруашвили Н.К., 20252025Громова О.А., Торшин И.Ю., Тетруашвили Н.К.Gromova O.A., Torshin I.Y., Tetruashvili N.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4229

Роли фолатов (витамин В9) в формировании здоровых ооцитов (что важно для предупреждения пороков развития) хорошо известны. Для реализации физиологических эффектов фолатов необходимы и другие витамины группы В – витамины В1, В6, В12 и В8 (инозитолы). Миоинозитол (МИ) и D-хироинозитол (ДХИ) – два наиболее изученных инозитола, необходимых для поддержки ооцитов, восстановления овуляторных циклов и профилактики фолат-резистентных пороков. Обмен ДХИ и МИ нарушается на фоне инсулинорезистентности, в т.ч. у пациенток с ожирением и с синдромом поликистоза яичников (СПЯ). И наоборот, дотации пациенткам МИ и ДХИ в физиологическом соотношении 40:1 способствуют устранению инсулинорезистентности, гиперандрогении, ановуляции, препятствующих формированию здоровых ооцитов и, следовательно, зачатию.

The roles of folates (vitamin B9) in the formation of healthy oocytes (which is important for preventing malformations) are well known. Other B vitamins are also necessary for the physiological effects of folates to be realized: vitamins B1, B6, B12, and B8 (inositols). Myoinositol (MI) and D-chiroinositol (DCI) are the two most studied inositols necessary for supporting oocytes, restoring ovulatory cycles, and preventing folate-resistant malformations. DCI and MI metabolism is impaired against the background of insulin resistance, including in patients with obesity and polycystic ovary syndrome (PCOS). Conversely, supplementing patients with MI and DCI in a physiological ratio of 40:1 helps eliminate insulin resistance, hyperandrogenism, and anovulation, which prevent the formation of healthy oocytes and, consequently, conception.

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The authors declare that there are no conflicts of interest present.